An antidiabetic nutraceutical combination of red yeast rice (<i>Monascus purpureus</i>), bitter gourd (<i>Momordica charantia</i>), and chromium alleviates dedifferentiation of pancreatic β cells in db/db mice

Lu, Ke-Ying; Chen, Szu-Han; Lin, Yu-Shun; Wu, Hai-Ping; Chao, Pei-Min

doi:10.1002/fsn3.1966

Cited by 9 publications

(3 citation statements)

References 35 publications

(65 reference statements)

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“…This finding is supported by the data on wound area reduction, which was greater in the treated groups than in the non-treated group. The underlying mechanism is that MJR enhances the expression of VEGF, increasing the production of hydroxyproline by fibroblasts [4]. High levels of hydroxyproline in the tissue indicate increased collagen content, which is crucial for wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…In Indonesia, MJR is commonly used as a İD İD İD İD İD İD İD İD coloring agent without altering taste, texture, or odor. In the realm of health, MJR has been found to have cholesterol-lowering and blood sugar-reducing properties [3,4]. Lin's research in 2019 further demonstrated that MJR possesses antioxidant and antibacterial abilities [3,5].…”

Section: Introductionmentioning

confidence: 99%

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Gel of Monascus purpureus JmbA rice accelerate wound healing in diabetic rats

Rahmawati SUTEJO,

WISUDANTI,

NISA

et al. 2024

jrp

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The most frequent complication of diabetes mellitus (DM) is diabetic ulcer, with a prevalence of 15-20% and an amputation rate of 30%. There is no effective and easy-to-apply treatment for acute-phase open wounds of patients with DM to prevent their development into ulcers. Monascus purpureus jmbA Rice (MJR) from Jember is superior to similar products from other regions in Indonesia because it has the highest monacolin content with an antioxidant effect. The study aimed to prove the effectiveness of MJR gel in accelerating the healing of acute wounds of diabetic rats. This true experimental laboratory research was a posttest-only control group design. We used Rattus norvegicus Wistar rats, 3-4 months old, weighing 200-300 grams. The 36 rats were divided into four treatment groups. The control group was given a gel of MJR 0%. The positive control group was given the antibiotic and placenta extract gel combination, and treatment groups T1 and T2 were given gel MJR40% and MJR80%. Excision wounds were made as deep as the subcutaneous layer on the back of the hyperglycemic rat. Four rats were terminated from each group on days 4, 11, and 18, and skin tissue was taken to observe the percentage of wound area shrinkage, epithelial thickness, and fibroblast count and analyze the levels of hydroxyproline and MDA. The MJR80% group had the highest percentage of wound area shrinkage, epithelial thickness, and fibroblast count compared to other groups. MDA levels decreased with increasing days in all treatment groups. Hydroxyproline levels increased on days 4 and 11, then decreased on day 18 in all treatment groups. We conclude that the 80% MJR group revealed the best acute diabetic wound healing. It was not statistically different from the combination of antibiotic and placenta extract gel treatment group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gel of Monascus purpureus JmbA rice accelerate wound healing in diabetic rats

Rahmawati SUTEJO,

WISUDANTI,

NISA

et al. 2024

jrp

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“…It is a well-known remedy for treating diabetes mellitus. Within eight weeks of regular consumption can result in decreasing the symptoms of diabetes mellitus like polydipsia, polyuria, and polyphagia (Lu et al, 2020) [89] .…”

Section: Management Of Diabetes Mellitusmentioning

confidence: 99%

Study on the anti-diabetic properties of functional foods: A review

Haldua

2024

Pharma Innovation

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The number of diabetic populations is increasing with much higher rate than predicted by various research authorities from various countries. Such drastic peak in diabetic population observed could be to changing lifestyle and unhealthy eating habits of majority of population. Mortality rates concerning with diabetes mellitus are higher in low-income countries due to lack of medical care and infrastructure. Diabetes mellitus is more dangerous when it invites other related complications like organ damage, retina and kidney damage, cardiovascular diseases and lack in the efficiency of nervous system. Various medicines are available which can administer orally or intravenously. These medications are efficient in reducing blood glucose levels of the body but in the same time they send signals to nervous system to stop the production of insulin permanently over a period of time as insulin is available in enough amounts from external sources. People tend to become dependent over medications for life time. In recent times, awareness regarding the clinical benefits of natural foods have been observed among researchers in order to treat diseases like diabetes mellitus and numerous natural foods which are antidiabetic in nature. These foods inhabit hypoglycaemic compounds which helps in reducing blood glucose levels and trigger the production of insulin naturally. This study focuses on nutritional aspects, in-vitro and in vivo studies conducted on pumpkin, flaxseeds and oats specifically, in order to prove their hypoglycaemic effect on human body. The exact mechanism and pathways behind this hypoglycaemic effect is difficult to establish, still few researches have predicted the most probable mechanism and pathways which have been discussed.

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