An Antibody-Mediated Bullous Skin Eruption Caused by Chronic Renal Allograft Rejection

Childhood bullous pemphigoid: A rare manifestation of chronic renal allograft rejection

“…1,3 As in our patient, the blistering stopped immediately after allograft nephrectomy in 2 cases. 1,4 The mechanism of BP associated with chronic allograft rejection is unknown. It is postulated that immunological activity within the rejected renal allograft is responsible for inducing formation of autoantibodies that react with the epidermal basement membrane.…”

“…It is postulated that immunological activity within the rejected renal allograft is responsible for inducing formation of autoantibodies that react with the epidermal basement membrane. 1,2,4 Our case showed a number of atypical features. Although the initial widespread eruption responded rapidly to treatment with oral corticosteroids, recurrent blisters continued to develop at sites of skin or mucosal trauma.…”

“…[1][2][3][4] In 2 patients, BP developed several years after transplantation 2,4 and in 2 children, BP occurred after a second failing transplant. 1,3 As in our patient, the blistering stopped immediately after allograft nephrectomy in 2 cases. 1,4 The mechanism of BP associated with chronic allograft rejection is unknown.…”

Bullous Eruption during Chronic Renal Allograft Rejection

“…Three cases of BP induced by chronic rejection of a grafted kidney and 2 cases following a graft-versus-host disease have been reported [3][4][5][6]. We describe the case of a BP-like eruption which began during the chronic rejection of a grafted kidney.…”

“…A 17-year-old young lady [3] developed a severe bullous eruption, with involvement of the oral mucosa, 2 months after the diagnosis of chronic rejection. Skin and kidney biopsies were performed.…”