An anti-inflammatory electroconductive hydrogel with self-healing property for the treatment of Parkinson’s disease

Xu, Junpeng; Tai, Chun‐Hwei; Chen, Tsai-Yu; Hsu, Shan‐hui

doi:10.1016/j.cej.2022.137180

Cited by 13 publications

(19 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antioxidant capacity of COA2 hydrogel was assessed using a previously published in vitro inflammatory NSC assay by quantifying the capability to scavenge ROS and rescue inflamed NSCs [ 24 ]. The VB-48 assay was applied to determine the cellular status pre- and post-treatment with the human IFN-γ as well as to study a further unhealthy/death ratio of inflamed NSCs embedded in two different hydrogels for 12 h, as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In vitro macrophage responses were also employed to assess the anti-inflammatory properties of hydrogel [ 24 ], through examination of the inflammation-related gene expression in J774A.1 macrophages by RT-PCR. Findings are revealed in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The in vitro evaluation assay for antioxidative and anti-inflammatory properties were performed following the previous published literature [ 24 ]. NSCs were preliminarily treated with human interferon gamma (IFN-γ, 0.1 ng/mL, Peprotech, USA) for 12 h to trigger reactive oxygen species (ROS)-induced neuro-inflamed unhealthy status.…”

Section: Methodsmentioning

confidence: 99%

“…A few studies showed that AuNPs were effective in treating PD, probably because AuNPs presented antioxidant and neuroprotective effects on brain cells [ 22 , 23 ]. Very recently, colloid AuNPs were added in a chitosan-polyurethane self-healing hydrogel, which through animal studies unveiled the potential of using conductive hydrogel alone in treating PD [ 24 ]. This work suggested that conductive hydrogels may not only be used as a drug/cell carrier, but also as curative tissue engineering scaffold materials.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson’s disease

Chen

Tai

et al. 2023

Biomater Res

Self Cite

View full text Add to dashboard Cite

Background Parkinson’s disease (PD) is one of the most common long-term neurodegenerative diseases. Current treatments for PD are mostly based on surgery and medication because of the limitation and challenges in selecting proper biomaterials. In this study, an injectable bioactive hydrogel based on novel tannic acid crosslinker was developed to treat PD. Methods The oxidized tannic acid modified gold nano-crosslinker was synthesized and used to effectively crosslink chitosan for preparation of the bioactive self-healing hydrogel. The crosslinking density, conductivity, self-healing ability, and injectability of the hydrogel were characterized. Abilities of the hydrogel to promote the proliferation and differentiation of neural stem cells (NSCs) were assessed in vitro. Anti-inflammatory property was analyzed on J774A.1 macrophages. The hydrogel was injected in the PD rat model for evaluation of the motor function recovery, electrophysiological performance improvement, and histological repair. Results The hydrogel exhibited self-healing property and 34G (~ 80 μm) needle injectability. NSCs grown in the hydrogel displayed long-term proliferation and differentiation toward neurons in vitro. Besides, the hydrogel owned strong anti-inflammatory and antioxidative capabilities to rescue inflamed NSCs (~ 90%). Brain injection of the bioactive hydrogel recovered the motor function of PD rats. Electrophysiological measurements showed evident alleviation of irregular discharge of nerve cells in the subthalamic nucleus of PD rats administered with the hydrogel. Histological examination confirmed that the hydrogel alone significantly increased the density of tyrosine hydroxylase positive neurons and fibers as well as reduced inflammation, with a high efficacy similar to drug-loaded hydrogel. Conclusion The new bioactive hydrogel serves as an effective brain injectable implant to treat PD and a promising biomaterial for developing novel strategies to treat brain diseases. Graphical Abstract

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson’s disease

Chen

Tai

et al. 2023

Biomater Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…As an important indicator of hydrogel dressings, electrical conductivity has been gradually explored in recent years, especially for wound healing under the joint action of electrical stimulation and dressings. , As shown in Figure d, PAA/ILs@L2 exhibits the highest conductivity of 9.06208 S/m compared with the other supramolecular hydrogel dressings. The conductivity of PAA/ILs@L1 and PAA/ILs@L0 is 8.68432 and 8.28157 S/m, respectively.…”

Section: Resultsmentioning

confidence: 99%

Supramolecular Hydrogel Dressing: Effect of Lignin on the Self-Healing, Antibacterial, Antioxidant, and Biological Activity Improvement

Han

Che

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The functionalization and performance improvement of supramolecular hydrogels are very important for their application in the wound dressing field. Inspired by the role of lignin in plant cell walls, sulfonated lignin is introduced into the supramolecular hydrogel to improve functionality, mechanical strength, and biological activity. According to the chemical structure characteristics of the sulfonated lignin and the requirements for wound dressing, a novel polymer system is designed and successfully synthesized to cooperate with the sulfonated lignin to form the supramolecular hydrogel dressings. The introduction of the sulfonated lignin can effectively improve the mechanical strength, self-healing property, antioxidant activity, and biological activity of the obtained supramolecular hydrogel dressings. In the rat wound healing model experiment, the supramolecular hydrogel dressings can maintain the moist environment on the wound surface, clean up the excretion of wound tissue, promote wound healing, and reduce the occurrence of inflammation. This supramolecular hydrogel dressing shows obvious potential for wound management and treatment by a facile and effective approach and has great promise for long-term application of wound dressings. This strategy for designing polymers according to the chemical structure characteristics of the sulfonated lignin and the application requirements has reference value for further development of biomass-based compound materials.

show abstract

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

Wang,

Liu,

Sun

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Modulating the inflammatory microenvironment can inhibit the process of inflammatory diseases (IDs). A tri‐cross‐linked inflammatory microenvironment‐responsive hydrogel with ideal mechanical properties achieves triggerable and sustained drug delivery and regulates the inflammatory microenvironment. Here, this study develops an inflammatory microenvironment‐responsive hydrogel (OD‐PP@SeNPs) composed of phenylboronic acid grafted polylysine (PP), oxidized dextran (OD), and selenium nanoparticles (SeNPs). The introduction of SeNPs as initiators and nano‐fillers into the hydrogel results in extra cross‐linking of the polymer network through hydrogen bonding. Based on Schiff base bonds, Phenylboronate ester bonds, and hydrogen bonds, a reactive oxygen species (ROS)/pH dual responsive hydrogel with a triple‐network is achieved. The hydrogel has injectable, self‐healing, adhesion, outstanding flexibility, suitable swelling capacity, optimal biodegradability, excellent stimuli‐responsive active substance release performance, and prominent biocompatibility. Most importantly, the hydrogel with ROS scavenging and pH‐regulating ability protects cells from oxidative stress and induces macrophages into M2 polarization to reduce inflammatory cytokines through PI3K/AKT/NF‐κB and MAPK pathways, exerting anti‐inflammatory effects and reshaping the inflammatory microenvironment, thereby effectively treating typical IDs, including S. aureus infected wound and rheumatoid arthritis in rats. In conclusion, this dynamically responsive injectable hydrogel with a triple‐network structure provides an effective strategy to treat IDs, holding great promise in clinical application.

show abstract

An anti-inflammatory electroconductive hydrogel with self-healing property for the treatment of Parkinson’s disease

Cited by 13 publications

References 56 publications

Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson’s disease

Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson’s disease

Supramolecular Hydrogel Dressing: Effect of Lignin on the Self-Healing, Antibacterial, Antioxidant, and Biological Activity Improvement

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

Contact Info

Product

Resources

About