An animal model of neuropathic pain employing injury to the sciatic nerve branches

Lee, Bae Hwan; Won, Ran; Baik, Eun Joo; Lee, Soo Hwan; Moon, Chang Hyun

doi:10.1097/00001756-200003200-00002

Cited by 156 publications

(128 citation statements)

References 19 publications

(21 reference statements)

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“…Conventional analgesics like non-steroidal anti-infl ammatory drugs and opioids are ineffective clinically in attenuating neuropathic pain. Further, tricyclic anti-depressants (i.e., amitriptyline, nortriptyline and imipramine) and anti-convulsants (i.e., phenytoin, carbamazepine, gabapentin, lamotrigine and topiramate) have also been reported to produce antiallodynic effects in neuropathy (Lee et al, 2000;Dwight, 2006). However, these drugs are reported to exhibit a wide spectrum of adverse effects which limit their full clinical exploitation in management of painful neuropathy (Carol & Jane 2006;Hama et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effects

Pandhare¹,

Sadasivam²,

Mohite³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The aim of present study was to investigate the attenuating effects of Adenanthera pavonina L., Leguminosae-Mimosaceae seeds aqueous extract (APSAE), in streptozotocin (STZ)-induced diabetic neuropathy in rats. APSAE (50, 100 and 200 mg/kg per day) was given to diabetic rats for twelve weeks. Cold and hot water tail immersion tests, photoactometer and Rota-rod tests were performed to assess degree of colder, thermal, spontaneous motor activity and motor co-ordination changes respectively at different time intervals i.e., week 0, 4, 8 and 12. Tissue superoxide anion and total calcium levels were determined after twelve weeks to assess biochemical alterations. Histopathological evaluations of sciatic nerve were also performed to assess nerve damage. APSAE treatment increased tail fl ick latency signifi cantly in diabetic rats. APSAE also reduced superoxide anion and total calcium levels. These results suggested that APSAE has attenuated development of diabetic neuropathy in streptozotocin-induced diabetic rats when compared with pregabalin (10 mg/kg, p.o.) and could be benefi cial in preventing the progression of diabetic nephropathy.

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Section: Introductionmentioning

confidence: 99%

Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effects

Pandhare¹,

Sadasivam²,

Mohite³

et al. 2012

Rev. bras. farmacogn.

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“…3,4) Moreover, post-thoracotomy, post-herniorrhaphy, post-mastectomy and post-sternotomy are some other conditions often associated with peripheral neuropathic pain. 5,6) Tibial and sural nerve transection is a novel model of neuropathic pain developed by Lee et al 7) characterized by vigorous mechanical allodynia, cold allodynia, mechanical hyperalgesia and spontaneous pain. [7][8][9] The animal model possesses number of advantageous over the other models such as easy surgical procedure and hence, high reproducibility.…”

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confidence: 99%

Ameliorative Potential of Pralidoxime in Tibial and Sural Nerve Transection-Induced Neuropathic Pain in Rats

Kaur

Jaggi

Singh

2010

Biological & Pharmaceutical Bulletin

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The present study was designed to investigate the ameliorative potential of pralidoxime in tibial and sural nerve transection-induced neuropathy in rats. Tibial and sural nerve transection was performed by sectioning tibial and sural nerve portions (2 mm) of the sciatic nerve, and leaving the common peroneal nerve intact. The pinprick, acetone, hot and cold tail immersion tests were performed to assess the degree of motor functions, mechanical hyperalgesia, cold allodynia, heat and cold hyperalgesia respectively. Biochemically, the tissue thio-barbituric acid reactive species (TBARS), super-oxide anion contents (the markers of oxidative stress) and total calcium levels were measured. Tibial sural nerve transection resulted in the development of mechanical hyperalgesia, cold allodynia, heat and cold hyperalgesia along with the rise in oxidative stress and calcium levels. However, administration of pralidoxime (10, 20 mg/kg intraperitoneally (i.p.)) for 14 d attenuated tibial and sural nerve transection-induced cold allodynia, mechanical, hot and cold hyperalgesia. Furthermore, pralidoxime also attenuated tibial and sural nerve transection induced increase in oxidative stress and calcium levels. It may be concluded that pralidoxime has ameliorative potential in attenuating the painful neuropathic state associated with tibial and sural nerve transection, which may possibly be attributed to decrease in oxidative stress and calcium levels.

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“…Other approaches include neurotrophic factors and antioxidants [12,17,18]. However, the clinical studies have failed to demonstrate the effectiveness of any drug treatment in improving nerve function, in addition to their wide spectrum of adverse effects which limit their usefulness [19,20].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

MOJAP

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Diabetic peripheral neuropathy (DPN) is an unwanted side effect that usually occurs in both types of diabetes mellitus (DM). Like other diabetic complications, the cause of DPN is not clear. This review will provide an experimental evidences on some common phytochemicals that used for the prevention or treatment of DPN. This review will not be only useful to doctors in making decisions about the best available phytochemical therapeutic choices of DPN but also to avoid the side effects of pharmacological drugs.

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An animal model of neuropathic pain employing injury to the sciatic nerve branches

Cited by 156 publications

References 19 publications

Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effects

Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effects

Ameliorative Potential of Pralidoxime in Tibial and Sural Nerve Transection-Induced Neuropathic Pain in Rats

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