An animal model of adult T-cell leukemia: humanized mice with HTLV-1–specific immunity

Tezuka, Kenta; Xun, Runze; Tei, Mami; Ueno, Takaharu; Tanaka, Masakazu; Takenouchi, Norihiro; Fujisawa, Jun–ichi

doi:10.1182/blood-2013-06-508861

Cited by 60 publications

(82 citation statements)

References 48 publications

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“…Although our in vitro data showed the susceptibility of T SCM cells to HTLV-1 infection, further studies such as detailed phenotypic and genetic analyses in a HTLV-1 infection model using humanized mice 40 will be required to delineate the exact nature of HTLV-1 infection and HTLV-1-infected cells.…”

Section: Discussionmentioning

confidence: 99%

T memory stem cells are the hierarchical apex of adult T-cell leukemia

Nagai

Kawahara

Hishizawa

et al. 2015

Blood

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Key Points• ATL clones are preserved in a rare CD4 together, these findings demonstrate the phenotypic and functional heterogeneity and the hierarchy of ATL cells. T SCM cells are identified as the hierarchical apex capable of reconstituting identical ATL clones. Thus, this is the first report to demonstrate the association of a T-cell malignancy with T SCM cells. (Blood. 2015;125(23):3527-3535)

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Section: Discussionmentioning

confidence: 99%

T memory stem cells are the hierarchical apex of adult T-cell leukemia

Nagai

Kawahara

Hishizawa

et al. 2015

Blood

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“…In all instances infection was transferred by HTLV-1 harboring cells, either with in vitro infected CD34 + HPCs or with lethally irradiated infected T cells [59][60][61]. In all three studies expansions of HTLV-1 infected CD25 + CD4 + T cells reminiscent of human adult T cell leukemia (ATL) were found.…”

Section: Apart From Hiv Human T Cell Leukemia Virus (Htlv) -1 Infectmentioning

confidence: 96%

Viral infections in mice with reconstituted human immune system components

Münz

2014

Immunology Letters

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Pathogenic viruses are often difficult to study due to their exclusive tropism for humans. The development of mice with human immune system components opens the possibility to study those human pathogens with a tropism for the human hematopoietic lineage in vivo. These include HCMV, EBV, KSHV, HIV, HTLV-1, dengue virus and JC virus. Furthermore, some human pathogens, like HSV-2, adenovirus, HCV, HBV and influenza A virus, with an additional tropism for somatic mouse tissues or for additional transplanted human tissues, mainly liver, have been explored in these models. The cellular tropism of these viruses, their associated diseases and primarily cell-mediated immune responses to these viral infections will be discussed in this review. Already some exciting information has been gained from these novel chimeric in vivo models and future avenues to gain more insights into the pathology, but also potential therapies, will be outlined. Although the respective in vivo models of human immune responses can still be significantly improved, they already provide preclinical systems for in vivo studies of important viral pathogens of humans. AbstractPathogenic viruses are often difficult to study due to their exclusive tropism for humans. The development of mice with human immune system components opens the possibility to study those human pathogens with a tropism for the human hematopoietic lineage in vivo. These include HCMV, EBV, KSHV, HIV, HTLV-1, dengue virus and JC virus. Furthermore, some human pathogens, like HSV-2, adenovirus, HCV, HBV and influenza A virus, with an additional tropism for somatic mouse tissues or for additional transplanted human tissues, mainly liver, have been explored in these models. The cellular tropism of these viruses, their associated diseases and primarily cell-mediated immune responses to these viral infections will be discussed in this review. Already some exciting information has been gained from these novel chimeric in vivo models and future avenues to gain more insights into the pathology, but also potential therapies, will be outlined. Although the respective in vivo models of human immune responses can still be significantly improved, they already provide preclinical systems for in vivo studies of important viral pathogens of humans.Christian Münz 3 Mice with reconstituted human immune system components as models of human immune responsesHuman immune responses can be studied in a correlative fashion in only a few tissues, which can be biopsied from patients or healthy individuals, including peripheral blood, some secondary lymphoid tissues, like tonsils, and the tumor microenvironment, assessing tumor infiltrating lymphocytes (TILs). For a more systematic analysis and in order to study the outcome of manipulations during immune responses, immunologists have primarily turned to the mouse as an in vivo animal model of mammalian immune responses. However, with a more and more detailed analysis of the mouse immune system it has become apparent that significant differences in ...

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“…1 H TLV-1 is a deltaretrovirus that is etiologically linked to ATL, an aggressive malignancy characterized by the monoclonal expansion of leukemic CD25…”

Section: Ecole Normale Supérieure De Lyonmentioning

confidence: 99%

Of mice, men, and HTLV-1

Dodon

2014

Blood

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An animal model of adult T-cell leukemia: humanized mice with HTLV-1–specific immunity

Cited by 60 publications

References 48 publications

T memory stem cells are the hierarchical apex of adult T-cell leukemia

T memory stem cells are the hierarchical apex of adult T-cell leukemia

Viral infections in mice with reconstituted human immune system components

Of mice, men, and HTLV-1

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