An ancient look at UCP1

Klingenspor, Martin; Fromme, Tobias; Hughes, David A.; Manzke, Lars; Polymeropoulos, Elias T.; Riemann, Tobias; Trzcionka, Magdalene K; Hirschberg, Verena; Jastroch, Martin

doi:10.1016/j.bbabio.2008.03.006

Cited by 63 publications

(45 citation statements)

References 46 publications

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“…To investigate whether adipogenic differentiation is a feature shared by tumor cells in clinical prostate cancer progression and bone metastasis, we examined adipogenic marker expression in a total of 45 human prostates by IHC assays. Here we present our findings regarding UCP1, an adipogenic marker exclusive to brown fat cells (27) that we found to be induced in prostate cancer cells (Figure 2). …”

Section: Resultsmentioning

confidence: 81%

“…Similarly, FABP4/aP2 was constitutively expressed, while LPIN1 was seen at a lower level and was induced transiently around 4 days of the induction (Figure 2B). Interestingly, the expression of UCP1, a brown adipocyte-specific gene functioning to uncouple energy metabolism (27), was induced 4 days into adipogenic induction (Figure 2B). These results thus revealed that prostate cancer cells could express adipocyte-specific markers both constitutively and after adipogenic induction.…”

Section: Resultsmentioning

confidence: 99%

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Human Prostate Cancer Harbors the Stem Cell Properties of Bone Marrow Mesenchymal Stem Cells

Zhau

Wang

et al. 2011

Clinical Cancer Research

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Purpose Prostate tumor cells frequently show the features of osteoblasts, which are differentiated from bone marrow mesenchymal stem cells. We examined human prostate cancer cell lines and clinical prostate cancer specimens for additional bone marrow mesenchymal stem cell properties. Experimental Design Prostate cancer cell lines were induced for osteoblastogenic and adipogenic differentiation, detected by standard staining methods and confirmed by lineage-specific marker expression. Abnormal expression of the markers was then assessed in clinical prostate cancer specimens. Results After osteoblastogenic induction, cells of the LNCaP lineage, PC-3 lineage and DU145 displayed osteoblastic features. Upon adipogenic induction, PC-3 lineage and DU145 cells differentiated into adipocyte-like cells. The adipocyte-like cancer cells expressed brown adipocyte-specific markers, suggesting differentiation along the brown adipocyte lineage. The adipogenic differentiation was accompanied by growth inhibition, and most of the adipocyte-like cancer cells were committed to apoptotic death. During cyclic treatments with adipogenic differentiation medium and then with control medium, the cancer cells could commit to repeated adipogenic differentiation and retrodifferentiation. In clinical prostate cancer specimens, the expression of UCP1, a brown fat-specific marker, was enhanced with the level of expression correlated to disease progression from primary to bone metastatic cancers. Conclusions This study thus revealed that prostate cancer cells harbor the stem cell properties of bone marrow mesenchymal stem cells. The abnormally expressed adipogenic UCP1 protein may serve as a unique marker, while adipogenic induction can be explored as a differentiation therapy for prostate cancer progression and bone metastasis.

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Section: Resultsmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Human Prostate Cancer Harbors the Stem Cell Properties of Bone Marrow Mesenchymal Stem Cells

Zhau

Wang

et al. 2011

Clinical Cancer Research

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“…Most importantly, brown adipocytes dissipate energy in the form of heat upon β-adrenergic stimulation. This process is mediated by uncoupling protein 1 (UCP1), a protein residing in the inner mitochondrial membrane, uncoupling the proton motive force of the respiratory chain, thereby combusting energy as heat (Klingenspor et al, 2008).…”

Section: Adipose Tissue Depotsmentioning

confidence: 99%

Heterogeneity of adipose tissue in development and metabolic function

Schoettl

Fischer

Ussar

2018

Journal of Experimental Biology

169

139

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Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is compartmentalized into individual depots and distributed throughout the body. These different adipose depots show major functional differences and risk associations for developing metabolic syndrome. Recent advances in lineage tracing demonstrate that individual adipose depots are composed of adipocytes that are derived from distinct precursor populations, giving rise to different populations of energy-storing white adipocytes. Moreover, distinct lineages of energy-dissipating brown and beige adipocytes exist in discrete depots or within white adipose tissue depots. In this Review, we discuss developmental and functional heterogeneity, as well as sexual dimorphism, between and within individual adipose tissue depots. We highlight current data relating to the differences between subcutaneous and visceral white adipose tissue in the development of metabolic dysfunction, with special emphasis on adipose tissue expansion and remodeling of the extracellular matrix. Moreover, we provide a detailed overview of adipose tissue development as well as the consensus and controversies relating to adult adipocyte precursor populations.

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“…The four gene families involved in mitochondrial transport also represent an evolutionary cluster (Figure 1): SLC25, with 43 members (the largest of all SLC families), is known to comprise the ‘mitochondrial carriers’, shuttling a variety of metabolites across the mitochondrial inner membrane;68 and UCP1,69 UCP270,71 and UCP370 (located at chromosomes 4q28-q31, 11q13 and 11q13.4, respectively) function as ancient uncoupling proteins, or proton pumps involved in mitochondrial energetics (Table 1). …”

Section: Transport Across Mitochondrial Membranesmentioning

confidence: 99%

Analysis and update of the human solute carrier (SLC) gene superfamily

2009

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The solute-carrier gene (SLC) superfamily encodes membrane-bound transporters. The SLC superfamily comprises 55 gene families having at least 362 putatively functional protein-coding genes. The gene products include passive transporters, symporters and antiporters, located in all cellular and organelle membranes, except, perhaps, the nuclear membrane. Transport substrates include amino acids and oligopeptides, glucose and other sugars, inorganic cations and anions (H+, HCO3-, Cl-, Na+, K+, Ca2+, Mg2+, PO43-, HPO42-, H2PO4-, SO42-, C2O42-, OH-,CO32-), bile salts, carboxylate and other organic anions, acetyl coenzyme A, essential metals, biogenic amines, neurotransmitters, vitamins, fatty acids and lipids, nucleosides, ammonium, choline, thyroid hormone and urea. Contrary to gene nomenclature commonly assigned on the basis of evolutionary divergence http://www.genenames.org/, the SLC gene superfamily has been named based largely on transporter function by proteins having multiple transmembrane domains. Whereas all the transporters exist for endogenous substrates, it is likely that drugs, non-essential metals and many other environmental toxicants are able to 'hitch-hike' on one or another of these transporters, thereby enabling these moieties to enter (or leave) the cell. Understanding and characterising the functions of these transporters is relevant to medicine, genetics, developmental biology, pharmacology and cancer chemotherapy.

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An ancient look at UCP1

Cited by 63 publications

References 46 publications

Human Prostate Cancer Harbors the Stem Cell Properties of Bone Marrow Mesenchymal Stem Cells

Human Prostate Cancer Harbors the Stem Cell Properties of Bone Marrow Mesenchymal Stem Cells

Heterogeneity of adipose tissue in development and metabolic function

Analysis and update of the human solute carrier (SLC) gene superfamily

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