An analysis of the role of presynaptic and postsynaptic slow potentials in sympathetic ganglia

Dempsher, John; Zabara, Jacob; Gelfand, R

doi:10.1016/0028-3908(62)90057-6

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…It is clear that Golgi had essentially the same view as expressed in Dempsher et al, in 1962-one being anatomical, the other being functional. As in the case of Golgi and Cajal, the authors of this paper and the Classical Theory are looking at the same waveforms (potentials), but seeing them in a different light.…”

Section: //mentioning

confidence: 72%

“…(2) Two distinctly different graded synaptic potentials were recorded simultaneously from the virus-infected structures: One localized to presynaptic terminations and one localized to postsynaptic structures (Dempsher, Zabara and Gelfand, 1962).…”

Section: A In Diseased Sympathetic Gangliamentioning

confidence: 99%

“…(3) The graded synaptic potential in the postsynaptic structures was clearly shown to be a mathematical derivative of the graded synaptic potential in the presynaptic terminations (Dempsher, Zabara and Gelfand, 1962;Mayer, 1966).…”

Section: A In Diseased Sympathetic Gangliamentioning

confidence: 99%

“…This was spelled out in a paper by Dempsher et al, 1962. The significance of this basic assumption was that protoplasmic continuity or contiguity between nerve terminations of one neuron, and dendrites and cell body of another neuron was of no significance as far as function was concernedtherefore, the fundamental assumption that the neuron was the fundamental unit of structure, and function consisted of transmission of excitation (and inhibition) across the cleft -were abandoned.…”

Section: //mentioning

confidence: 99%

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Synaptic function in the nervous system: A theory and its application

Dempsher

1979

Acta Biotheor

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The objective of this paper is to present a new theory of synaptic function in the nervous system. The basis for this theory is the experimental demonstration that a nerve impulse assumes five different forms as it advances through the synaptic region, and that five basic mathematical operations have been identified as being involved in the transformation of one form into another form. As a result of these data, the synaptic region is regarded as a functional unit where information coming to it is unpacked, processed, stored, and retrieved for transit to another synaptic region or effector site. The data also suggests that a nerve impulse is a bolus of energy, therefore, without substance; that it contains information coded in its shape or form; that it is precisely described mathematically. Furthermore, the data suggests synaptic regions process these nerve impulses by applying mathematical operations to them; that function in the synaptic region is highly stereotyped (programmed); that chemical substances are associated with the mathematical operations. The basic approach of this theory is to regard a significant portion of the nervous system as an 'interface' between the external universe and man himself. As an interface, the nervous system receives and processes information from both the external universe and man himself in a programmed manner. The interface functions by converting the information it receives into a bolus of energy, the nerve impulse, then processes the bolus by converting it into numbers or functions and applying mathematical operation to it.

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Section: //mentioning

confidence: 72%

Section: A In Diseased Sympathetic Gangliamentioning

confidence: 99%

Section: A In Diseased Sympathetic Gangliamentioning

confidence: 99%

Section: //mentioning

confidence: 99%

See 2 more Smart Citations

Synaptic function in the nervous system: A theory and its application

Dempsher

1979

Acta Biotheor

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“…There is an addition to the schematic as it appeared in the previous publication (Dempsher, 1979). mSP-miniature symaptic potentials -are also positioned on the presynaptic side because mSP were also observed there by Dempsher, Zabara and Gelfand (1962) and Nishi (1970). In the Classical Theory they only appear on the postsynaptic side of the synapse.…”

Section: Introductionmentioning

confidence: 99%

Integration of function in the nervous system ? A new theory

Dempsher

1979

Acta Biotheor

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A new theow of synaptic function in the nervous system (Dempsher, 1978) is applied to the simplest system for integration of function in the nervous system. This system includes a sensory and motor neuron and three 'synaptic' regions associated with those two neurons; a receptor region, an interneuronal spinal synaptic region linking the two neurons, and an effector region.Information is first received and processed at the receptor region. The processing consists of five components: I. A highly selective mechanism which allows only that information to enter the receptor system which is appropriate. 2. The 'appropriateness' of the information is determined by the alphabet (miniature potentials) already in that area. 3. The information entering the system is assembled in a pattern meaningful for the next processing operation. 4. The assembled information is then 'disassembled' into its subuults and mapped into the alphabet (miniature potentials). 5. These miniature potentials are assembled into another pattern meaningful to fit the role of the receptor region. 6. This new pattern is repacked for transit to the central synaptic region.At the central synaptic region, essentially the same process takes place except here an additional operation takes place which determines its role in the processing system. The incoming information is disassembled into its subunlts, mapped into the miniature potentials already there; these are collected together in a meaningful pattern, 'operated' on, then repacked for transit to the effector site, where again the same kind of processing sequence takes place.In all three regions, despite the difference in their roles, there are similar processing features:(1) In each region, three forms of the nerve impulse are involved: miniature graded potentials, graded potentials, action potentials.(2) In each region, each component of the process is carried out by a precise mathematical operation: four each in the receptor and effector regions; five in the cen'cral synaptic region. JOHN DEMPSHERIt is suggested that integration of function in the nervous system consists of converting information into energy which is in turn converted into a number. Processing of information at each region then involves mathematical operations applied to these numbers. Function appears to be stereotyped in aU three regions. The receptor region receives highly selective and restrictive information so that the universe we 'perceive' would appear to be a subset of a much larger universe.

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Reflex and autorhythmicity: A formal model

Zabara

1969

Mathematical Biosciences

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An analysis of the role of presynaptic and postsynaptic slow potentials in sympathetic ganglia

Cited by 4 publications

References 12 publications

Synaptic function in the nervous system: A theory and its application

Synaptic function in the nervous system: A theory and its application

Integration of function in the nervous system ? A new theory

Reflex and autorhythmicity: A formal model

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