An analysis of prognostic factors in early stage Hodgkin's disease

A risk factor for relapse in Hodgkin's disease: Female gender?

“…However subsequent studies have reported that mediastinal involvement is closely associated with other parameters of increased tumour burden such as B symptoms and advanced stage. Multivariate statistical methods have shown that mediastinal involvement is not an independent poor prognostic factor in most series (Cosset et al, 1984;Pillai et al, 1985;Sutcliffe et al, 1984;Tubiana et al, 1985;Horwich et al, 1986). In contrast, Hoppe et al (1982) report mediastinal bulk as a predictor of shorter disease-free survival but this did not account for the inferior outcome for females in our series.…”

“…Factors predicting for overall survival in patients with Hodgkin's disease include age (Haybittle et al, 1985;Sutcliffe et al, 1984;Tubiana et al, 1985;Horwich et al, 1986), stage (Sutcliffe et al, 1984), histology (Haybittle et al, 1985;Sutcliffe et al, 1984;Tubiana et al, 1985), mediastinal disease (Haybittle et al, 1985), ESR (Haybittle et al, 1985), male sex (Haybittle et al, 1985;Tubiana et al, 1985), number of extranodal sites and drug dose intensity (Pillai et al, 1985). In Christchurch there has been a clinical impression that females with nodular sclerosis Hodgkin's disease involving the mediastinum relapsed more frequently than expected according to the published risk factors.…”

“…Factors which predict the length of CR include B symptoms (Cosset et al, 1984;Tubiana et al, 1985;Longo et al, 1986), stage (Haybittle et al, 1985;Sutcliffe et al, 1984;Horwich et al, 1986), histology (Haybittle et al, 1985;Sutcliffe et al, 1984;Specht et al, 1987), number of disease sites (Cosset et al, 1984;Tubiana et al, 1985;Horwich et al, 1986), age (Sutcliffe et al, 1984;Tubiana et al, 1985;Longo et al, 1986), male sex (Tubiana et al, 1985;Specht et al, 1987), erythrocyte sedimentation rate (ESR) (Haybittle et al, 1985;Tubiana et al, 1985), tumour burden (Specht et al, 1987), number of extranodal sites (Longo et al, 1986), the presence of bulky mediastinal disease (Hoppe et al, 1982), time to achieve CR (Longo et al, 1986) and drug dose intensity (Pillai et al, 1985).…”

Radiotherapy for Early Stage of Hodgkin’s Disease at Kuwait Cancer Control Center, Kuwait

“…These include favorable histological subtypes, absence of B symptoms, age, normal erythrocyte sedimentation rate, irradiation fraction size, gender, no more than 3 nodal areas involved, the number of fields treated daily and the overall treatment time in days [9][10][11][12][13][14][15].…”

Hodgkin'S Disease in Northern Sweden 1971-1981 Ii. A Retrospective Analysis of Prognostic Factors

“…For the elderly patients with HD this improvement is less obvious or even doubtful (3,(5)(6)(7)(8)(9). The clinical management is, however, largely based on experiences gained from the treatment of young patients (10)(11)(12)(13)(14)(15)(16)(17).…”