An analysis of mortality and survival of COVID 19 patients admitted to a tertiary care hospital in Maharashtra, India

Abstract

Background After nine months of responding to the coronavirus disease-19 (COVID-19) pandemic, the scientific fraternity is yet to unravel the mystery of those who are at most risk from mortality. Despite resistance to wear masks, the global public health response has beaten the grimmer projections of millions of deaths. The present study seeks to analyze the survival of COVID-19 patients at a tertiary care hospital and identify the risk factors of mortality. Methods Medical records of 1233 RT PCR confirmed COVID-19 patients admitted in a tertiary care hospital between 01 April and 30 September 2020 were retrospectively analyzed for calculating overall survival and to investigate the independent predictors of survival of COVID-19 patients. Results There were 72 (5.8%) deaths; which occurred in 24.9% of the elderly (age > 60yrs) people (P < 0.001), 76.0% in people with multiple comorbidities (having more than one comorbidity) (P < 0.001), 75.6% in people with diabetes (P < 0.001), and 75.5% in people with hypertension (P < 0.001). A significantly higher risk of mortality was observed in elderly patients, patients with comorbidities, and patients requiring oxygen while admitted in the hospital. Conclusion Survival reflects the cure rates and is used by health professionals and policymakers to plan and implement disease control measures. The insights provided by the study would help facilitate the identification of patients at risk and timely provision of specialized care for the prevention of adverse outcomes in the hospital setting.

Characteristics and Subgroup Analysis of Risk Factors Associated with In-Hospital Mortality among COVID-19 Patients: A Retrospective Cohort Study

“…Men were more likely to report fever (57.6%), while women reported chest pain (8.65), nausea (15%), and seizures more (5.1%) (P < 0.05). The prevalence of symptoms of cough, respiratory distress, muscle pain, headache, weakness, and loss of sense of smell was signi cantly associated with the death from COVID- (42). We observed no differences in the median length of hospitalization among males and females and pandemic waves in Kaplan Meir method, but the median length of hospitalization in older patients was signi cantly higher than young patients.…”

REcovery and SURvival of patients with moderate to severe acute REspiratory distress syndrome (ARDS) due to COVID-19: a multicentre, single-arm, Phase IV Itolizumab Trial: RESURRECT

“…In the RECOVERY and COVACTA tocilizumab treated arms, patients who required any supplemental oxygen (equivalent to score-5 on the COVID-19 8-point ordinal scale) had mortality rates of 19% and 11.5% and those requiring NIV/HFNC (equivalent to score-6 on the ordinal scale) had mortality rates of 38% and 19.1%, respectively. 24,31 In the current study, mortality was 2.7% for ordinal score-5 and 17.9% for ordinal score-6 patients treated with Itolizumab.…”

“…Table 5). [26][27][28][29][30][31] Mortality at 1-month has been observed to be 19.4%, 35% and 15.2% in the control-arms and 19.7%, 31% and 11.4% in the treatment-arms of the COVACTA, RECOVERY (Tocilizumab) and ACTT-1 trials, respectively. 24,25,32 A lower percentage of patients received systemic corticosteroids in the COVACTA (tocilizumab, 33.7%; control, 52.1%) and ACTT-1 (Remdesivir, 21.6%; control, 24.4%) trials though a higher proportion of patients received steroids in the RECOVERY trial (tocilizumab, 82%; control, 82%) and in the current study (Itolizumab, 85.3%).…”

Determinan Risiko Kematian Pasien Covid-19

“…Beberapa penelitian telah dilakukan terkait variabel-variabel yang berpengaruh signifikan terhadap risiko kematian pasien Covid-19, di antaranya Bobdey et al, (2021) dan Sousa et al (2020) yang menyebutkan bahwa usia pasien memengaruhi risiko kematian akibat Covid-19. Ghosh et al (2021) menyatakan bahwa jenis kelamin pasien juga berpengaruh signifikan terhadap risiko kematian, yang mana pada umumnya pasien perempuan memiliki ketahanan yang lebih baik dibandingkan pasien laki-laki karena sistem imun yang lebih responsif (Schurz et al, 2019) dan perilaku hidup yang lebih baik (The Lancet, 2020).…”

“…Kedua, informasi yang dicatat dalam rekam medis diharapkan dapat mencakup lebih banyak karakteristik pasien, sehingga dapat menggunakan lebih banyak informasi dalam menganalisis tingkat risiko kematian pasien Covid-19. Tambahan informasi yang dapat digunakan untuk analisis selanjutnya antara lain banyak komorbid yang dimiliki (Pinato et al, 2021), tingkat saturasi oksigen (Bobdey et al, 2021), dan tingkat keparahan klinis pasien (Hewitt et al, 2020).…”