An analysis of host and donor contributions to splenic enlargement in chick embryos inoculated with adult chicken spleen cells

The Identification of Cells During the Proliferative Phase of Spleen Enlargement of Chick Embryos Following Injection with Adult Blood

“…In the chicken, Murphy (1916) believed the enlargement to be due to the multiplication of embryo cells stimulated by the graft. The same conclusion was reached by Seto and Albright (1965) using donor cells labelled with tritiated thymidine. The increased mitotic activity of the embryo spleen suggested to them that the host cells were making an appreciable contribution to splenomegaly.…”

Genetic Differences in the Homologous Splenomegaly Reaction in Chickens Due to the Donor

“…It was reported that splenomegaly reaction was due in part to the proliferation of host spleen cells (Howard et al 1961;Mun and Burns 1964;Seto and Albright 1965). Although it is not clear to what extent an immunological response by the host contributes to the splenomegaly, the differences in donor antigen would seem to induce differences in degree of host response.…”

The Interaction of Donor and Host Lymphoid Cells in the Pathogenesis of Renal Cortical Destruction Induced by a Local Graft Versus Host Reaction

“…This conclusion is sustained by preliminary studies which indicate that it is possible to achieve renal GVHR's in heavily irradiated hosts by inclusion of hybrid host-type lymphoid cells along with the parental component in the inoculum. The development of other GVHR's, both local and systemic, has in some cases been inhibited by prior host irradiation (4,6,10), whereas the virulence of others has been enhanced by such treatment (11)(12)(13). Thus the striking effect observed here is neither unique nor universal, but certainly it raises interesting possibilities about the ways in which inflammatory mononuclear cells can operate.…”