Genetic Differences in the Homologous Splenomegaly Reaction in Chickens Due to the Donor

The Quantitative Effects of the B Blood Group Locus and Sex Linked Histocompatibility Antigen in Chickens on G-v-H Reaction

“…Donor cells having the B gene produced a greater splenomegaly than those having the B 9 gene (Mikami et al, 1969;Fujio, 1970). However, in the present study this was not true (Table 1).…”

Gene Controlled Differences of the Graft-Versus-Host Reaction Activity in the Chicken

“…However, there was no correlation between the number of foci and the mean spleen weight in BbBb hosts inoculated with various numbers of leucocytes from BABA donors. Mikami et al (1969) reported that the degree of splenomegaly in White Rock embryos induced by injection with blood cells from the N strain of White Leghorn was higher than that induced by blood cells from the C strain of White Leghorn.…”

Developmental Changes in Some Blood Group Antigens in the Chick

“…Okada et al (1962) determined the time of appearance from the comparison between the expected values from the genotypes of parantal populations and observed number of birds giving positive reaction. Mikami et al (1969) found that the splenomegaly was induced in B'B' embryos by injection with the blood of BABA and BCBC adults when the blood from the latter was injected intravenously into 14-day embryos of the former, the spleen of which was weighed at 5th day after injection. This suggested that the I antigen (appeared at the fifth day after hatching, according to Okada et al 1962) became detectable antigenically at the latest on the 14-19th day of incubation, since the splenomegaly was the result of a graft-versus-host reaction which was dependent on the host possessing an antigen of the B system which the graft did not possess.…”