“… 12 More recently, established Frey's Syndrome is treated through the use of nonsurgical methods, such as topical glycopyrrolate 13–15 and cutaneous injections of botulinum toxin type A, 3,4 and surgical methods have been reserved for Frey's Syndrome refractory to medical treatment, 12 and more importantly for the prevention of Frey's Syndrome using the concept of a barrier method. 8,16–20 Studies examining the efficacy of Botox (Allergan, Inc., Mougins, France) have demonstrated mean durations of effect from 12.1 months to 17.3 months 3,4,21 ; however, Laskawi and Drobik have the largest group of patients treated with Botox and demonstrate a mean duration of effect of 17.3 months. 21 Other studies more or less concur with these numbers; however, of particular note is that although 100% of patients respond to botulinum toxin type A, there is nearly always the need for subsequent injections.…”