An alternate synthesis of levetiracetam

Conformational Preference and Spectroscopical Characteristics of the Active Pharmaceutical Ingredient Levetiracetam

“…Comparing our NMR data for LEV in D 2 O and those corresponding to the CDCl 3 solvent, 25,52,87 the most important differences are noted for C2, C10 and the amino protons. The resonances of the last 2 protons appear in D 2 O at 7.61 and 7.10 ppm indicating their deshielding compared to the chloroform solution.…”

“…Previously reported NMR data for LEV 25,52,87 have been recorded in CDCl 3 , and to the best of our knowledge, no such data exist for LEV in water. For this reason, we decided to do an experimental work on both 1 H and 13 C NMR spectra of LEV in this solvent.…”

Solubility Measurement and Thermodynamic Properties of Levetiracetam in Pure and Mixed Solvents

“…Melting properties measurement. Some literature accounts have reported T m of levetiracetam; 4,5,14 nevertheless Δ fus H of levetiracetam has not been determined. For the sake of using thermodynamic models to correlate the solubility values, in order to obtained the Δ fus H of levetiracetam, a differential scanning calorimetric instrument (Pyris-Diamond, PerkinElmer) was used to measure the Δ fus H of levetiracetam.…”

“…1,7−10 Since its launch in 2000, levetiracetam has emerged as one of the most prescribed antiepileptic medicines. 4 As a result, synthetic chemists pay more attention to the preparation methods of levetiracetam, and put forward many preparation methods of levetiracetam at home and abroad. 11−29 However, during the synthesis of levetiracetam, it is easy to generate levetiracetam acid and ethyl levetiracetam due to the reaction conditions.…”

“…102767-28-2, Figure ) has been approved as an add-on therapy for the treatment of refractory epilepsy. − Levetiracetam is a highly effective antiepileptic agent with a wide margin of safety and straightforward pharmacokinetics that distinguish it from other currently available antiepileptic drugs. It has shown outstanding pharmacokinetic and pharmacological activity which has led to the rapid approval of this antiepileptic drug by the Food and Drug Administration (FDA). − In addition, compared with traditional therapy, levetiracetam has several advantages of twice-daily dosing, a wide margin of safety with no requirements for serum drug concentration monitoring and no interactions with other anticonvulsants, and less adverse effects than traditional treatments. ,− Since its launch in 2000, levetiracetam has emerged as one of the most prescribed antiepileptic medicines . As a result, synthetic chemists pay more attention to the preparation methods of levetiracetam, and put forward many preparation methods of levetiracetam at home and abroad. − However, during the synthesis of levetiracetam, it is easy to generate levetiracetam acid and ethyl levetiracetam due to the reaction conditions.…”