Protecting‐Group‐Free Synthesis of Drugs and Pharmaceuticals

Ramesh, Remya; Sonawane, Swapnil P.; Reddy, D. Srinivasa; Bandichhor, Rakeshwar

doi:10.1002/9781119295266.ch6

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2022

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Cited by 2 publications

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“…The protecting-group-free synthesis of drugs or active pharmaceutical ingredients is a great challenge. 24 Due to the presence of many hydroxyl groups, the reduction of protection-deprotection steps is even more challenging for the preparation of nucleoside analogues. To the best of our knowledge, there is currently no chemical protecting-group-free synthesis of biologically active fluorinated nucleosides.…”

Section: Introductionmentioning

confidence: 99%

Protecting-group-free synthesis of clevudine (l-FMAU), a treatment of the hepatitis B virus

2022

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Section: Introductionmentioning

confidence: 99%

Protecting-group-free synthesis of clevudine (l-FMAU), a treatment of the hepatitis B virus

2022

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Synthesis of Lincosamide Analogues via Oxime Resin Aminolysis

Tremblay

Haguette

Robert-Scott

et al. 2022

Synlett

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In this work, the synthetic development of an oxime resin aminolysis to lincosamide analogues is described. This synthetic endeavour hinges on a protecting-group-free strategy of the aminosugar nucleophiles. The cleavage from the solid support is achieved under mild condition in a buffer solution and allows the preparation a wide diversity of amino acid moieties onto glycosylamine scaffolds. The strategy is further exploited using methylthiolincosamine to generate rapidly complex lincomycin analogues. The results pave the way to access efficiently novel potentially relevant antibacterial compounds.

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Protecting‐Group‐Free Synthesis of Drugs and Pharmaceuticals

Cited by 2 publications

References 57 publications

Protecting-group-free synthesis of clevudine (l-FMAU), a treatment of the hepatitis B virus

Protecting-group-free synthesis of clevudine (l-FMAU), a treatment of the hepatitis B virus

Synthesis of Lincosamide Analogues via Oxime Resin Aminolysis

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