An ALP-activatable and mitochondria-targeted probe for prostate cancer-specific bimodal imaging and aggregation-enhanced photothermal therapy

Yao, Defan; Yang, Shuyan; Wang, Yanshu; Bian, Kexin; Yang, Wenjun; Wang, Dengbin; Zhang, Bingbo

doi:10.1039/c9nr00913b

Cited by 57 publications

(41 citation statements)

References 54 publications

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“…The photothermal conversion capability of small molecule PTAs was regulated by the electrical changes initiated from the regulation of specic substances in tumor cells. 113 An aggregation-enhanced PTT probe (termed as ETP) was developed by Yao et al for mitochondria-targeted imaging and therapy, 98 which was activated by alkaline phosphatase (ALP) (Fig. 6a right).…”

Section: Dtptas Based On Cyanine Dyesmentioning

confidence: 99%

Dual-targeted photothermal agents for enhanced cancer therapy

et al. 2020

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Section: Dtptas Based On Cyanine Dyesmentioning

confidence: 99%

Dual-targeted photothermal agents for enhanced cancer therapy

et al. 2020

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“…In addition to the above‐introduced ALP‐activatable probes employed for imaging, theranostic systems triggerable by ALP have also been reported. [ 90 ] The enzyme‐activatable theranostic probe ETP is composed of a NIR emitter, namely the hemicyanine dye, a mitochondria‐targeting hydrophobic triphenylphosphonium group, and a phosphate ester group. In this probe, the hemicyanine contributes to the NIR FL/PA imaging and phototherapy, and the phosphate ester unit works not only as the ALP substrate but also as a quencher to the FL/PA signals of the hemicyanine in its original form.…”

Section: Advances Of Enzyme‐activatable Optical Probesmentioning

confidence: 99%

“…[87] In view of its overexpression in tumors and its importance in early diagnosis and therapy of cancers, such as metastatic prostate cancer, several ALP-activatable probes have been explored for the specific imaging or theranostics of cancer. [88][89][90][91][92][93] 24 and 25 are displayed in Figure 12 as representatives of the developed ALPtriggerable probes.…”

Section: N-acetyl-β-d -Glucosaminidase (Nag)mentioning

confidence: 99%

Most recent advances on enzyme‐activatable optical probes for bioimaging

Mei

Tian

2021

Aggregate

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Enzymes are essential biological elements that play vital roles in many key cellular events and physiological processes. The dysregulation of enzyme activity broadly occurs in a large number of diseases ranging from inflammation to neurodegenerative disorders to tumors. Molecular imaging allows accurate and noninvasive visualization of biological analytes/physiological processes of interest closely linked to human health at different levels. Among various imaging modalities, optical imaging stands out benefited from its high sensitivity, excellent spatiotemporal resolution, real‐time mode, and facile accessibility. Diverse optical probes specifically activatable by disease‐relevant enzymes have sprung up. In comparison to the “always‐on” counterparts, the “off‐on” imaging probes activated by enzymes hold great promise for precise diagnosis of diseases at early stage with high target‐to‐background ratio, dramatically improved specificity, and significantly enhanced sensitivity. Herein, the most recent advances in optical probes activatable by enzymes for biosensing and bioimaging are briefly reviewed emphasizing their molecular design, working mechanism, and biomedical applications. Besides, some important prospects and the current challenges to fully implement the potential of enzyme‐activatable probes for precise and efficient theranostics in life science are also pointed out to hopefully arouse new insights into the development of new generation of theranostics.

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“…In another design, Zhang and co‐workers reported a prostate cancer imaging platform using an ALP‐activatable and mitochondria‐targeted probe. [ 78 ] The FL and PA intensity of the probe (ETP), composed of a NIR FL dye, a lipophilic triphenylphosphium cation that targets mitochondria, and a phosphate ester group, was drastically increased after incubating with ALP. The enhancement was attributed to the removal of the phosphate group that quenched FL/PA signal and resulted in situ NPs self‐assembly.…”

Section: Internal Targets For Nanomaterials Activationmentioning

confidence: 99%

Internally Responsive Nanomaterials for Activatable Multimodal Imaging of Cancer

Rosenkrans

Ferreira

et al. 2020

Adv Healthcare Materials

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Advances in technology and nanomedicine have led to the development of nanoparticles that can be activated for multimodal imaging of cancer, where a stimulus induces a material modification that enhances image contrast. Multimodal imaging using nanomaterials with this capability can combine the advantages and overcome the limitations of any single imaging modality. When designed with stimuli‐responsive abilities, the target‐to‐background ratio of multimodal imaging nanoprobes increases because specific stimuli in the tumor enhance the signal. Several aspects of the tumor microenvironment can be exploited as an internal stimulus response for multimodal imaging applications, such as the pH gradient, redox processes, overproduction of various enzymes, or combinations of these. In this review, design strategies are discussed and an overview of the recent developments of internally responsive multimodal nanomaterials is provided. Properly implementing this approach improves noninvasive cancer diagnosis and staging as well as provides a method to monitor drug delivery and treatment response.

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An ALP-activatable and mitochondria-targeted probe for prostate cancer-specific bimodal imaging and aggregation-enhanced photothermal therapy

Abstract: We developed a mitochondria-targeted near-infrared activatable fluorescent/photoacoustic (NIR FL/PA) probe for the selective detection of prostate cancer-derived ALP and aggregation-enhanced photothermal therapy.

Cited by 57 publications

References 54 publications

Dual-targeted photothermal agents for enhanced cancer therapy

Dual-targeted photothermal agents for enhanced cancer therapy

Most recent advances on enzyme‐activatable optical probes for bioimaging

Internally Responsive Nanomaterials for Activatable Multimodal Imaging of Cancer

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