An All‐in‐One Organic Semiconductor for Targeted Photoxidation Catalysis in Hypoxic Tumor

Abstract

Tumor hypoxia severely limits the therapeutic effects of photodynamic therapy(PDT). Although many methods for oxygen generation exist, substantial safety concerns,spatiotenporal uncontrollability,l imited efficacy,a nd complicated procedures have compromised their practical application. Here,w ed emonstrate ab iocompatiable all-in-one organic semiconductor to provide aphotoxidation catalysis mechanism of action. Afacile method is developed to produce gram-level C 5 N 2 nanoparticles (NPs)-based organic semiconductor.U nder 650 nm laser irradiation, the semiconductor split water to generate O 2 and simultaneously produce singlet oxygen ( 1 O 2 ), showing that the photocatalyst for O 2 evolution and the photosensitizer (PS) for 1 O 2 generation could be synchronously achieved in one organic semiconductor.T he inherent nucleus targeting capacity endows it with direct and efficient DNAp hotocleavage.T hese findings pave the way for developing organic semiconductor-based cancer therapeutic agents.

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

“…Here, US-generated electrons remain on the CB of N–carbon, which possesses enough potential (−0.33 eV) to trap the dissolved O 2 to generate ·O 2 – . Moreover, there are two accepted mechanisms for 1 O 2 generation: (I) the oxidation of ·O 2– by hole and (II) energy transfer mechanism. , As exhibited in Figure S9, methanol (MeOH, hole trapper) is added to increase 1 O 2 , suggesting that holes do not directly determine 1 O 2 production and the formation process is dominated by path II instead of path I. Moreover, the addition of silver nitrate (Ag + , electron trapper) or the removal of dissolved O 2 decrease 1 O 2 generation.…”

“…As shown in Figure S8, Co peaks shift to a lower bonding energy region, demonstrating the electron transfer from N−carbon to CoP when they are constructed to form a heterostructure. It is noted that CoP/N−carbon 29,30 As exhibited in Figure S9, methanol (MeOH, hole trapper) is added to increase 1 O 2 , suggesting that holes do not directly determine 1 O 2 production and the formation process is dominated by path II instead of path I. Moreover, the addition of silver nitrate (Ag + , electron trapper) or the removal of dissolved O 2 decrease 1 O 2 generation.…”

Backbone flexibility/amphiphilicity modulation of AIE active polyelectrolytes for mitochondria- and nucleus-targeted synergistic photodynamic therapy of cancer cells

“…24,71,72 Therefore, two assumptions were conceived to interpret the difference of the subcellular destination of S4 and D4 nanoparticles: (1) this is caused by the difference in the zeta potential between the S4 and D4 nanoparticles, i.e., the AIE polyelectrolyte nanoparticles with a lower zeta potential favors accumulation at the nucleus while the nanoparticles with a higher zeta potential favors localization at the mitochondria; 55 (2) the difference might stem from the tweaking on the molecular flexibility/amphiphilicity of the AIE polyelectrolytes, which might further alter the composition of the protein corona absorbed around the nanoparticles and influence their subcellular trafficking route, leading to different subcellular destinations eventually. [73][74][75][76] To verify the first assumption, nanoparticles with varying zeta potentials but a similar structure are necessitated. Therefore, a simple mixing method was developed to prepare such nanoparticles.…”