An all-in-one nanoplatform with near-infrared light promoted on-demand oxygen release and deep intratumoral penetration for synergistic photothermal/photodynamic therapy

Liu, Xiangmei; Li, Ruhua; Zhou, Yanli; Lv, Wen; Liu, Shujuan; Zhao, Qiang; Huang, Wei

doi:10.1016/j.jcis.2021.10.082

Cited by 9 publications

(9 citation statements)

References 42 publications

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“…This elegant nanoplatform improved RT treatment in mouse models and achieved efficient and desirable therapeutic outcomes with reduced toxicity [ 60 ]. In more recent work, Liu et al [ 61 ] developed a novel on-demand O 2 releasing NP triggered by NIR light to achieve synergistic photodynamic/photothermal therapy. This smart nanoplatform displayed both deep intratumor penetration and high tumor accumulation rates.…”

Section: Chemical Modulation Of the Tme Using Nanoparticlesmentioning

confidence: 99%

“…This smart nanoplatform displayed both deep intratumor penetration and high tumor accumulation rates. It also achieved continuous, on-demand complete oxygen release to relieve hypoxia during phototherapy and allowed imaging-guided dual-model cancer therapy [ 61 ]. This work could thus serve as a proof-of-concept model for designing nano-solutions with prolonged oxygen release that enable synergistic phototherapy in hypoxic tumors.…”

Section: Chemical Modulation Of the Tme Using Nanoparticlesmentioning

confidence: 99%

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Nanoparticles mediated tumor microenvironment modulation: current advances and applications

et al. 2022

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The tumor microenvironment (TME) plays a key role in cancer development and emergence of drug resistance. TME modulation has recently garnered attention as a potential approach for reprogramming the TME and resensitizing resistant neoplastic niches to existing cancer therapies such as immunotherapy or chemotherapy. Nano-based solutions have important advantages over traditional platform and can be specifically targeted and delivered to desired sites. This review explores novel nano-based approaches aimed at targeting and reprogramming aberrant TME components such as macrophages, fibroblasts, tumor vasculature, hypoxia and ROS pathways. We also discuss how nanoplatforms can be combined with existing anti-tumor regimens such as radiotherapy, immunotherapy, phototherapy or chemotherapy to enhance clinical outcomes in solid tumors.

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Section: Chemical Modulation Of the Tme Using Nanoparticlesmentioning

confidence: 99%

Section: Chemical Modulation Of the Tme Using Nanoparticlesmentioning

confidence: 99%

Nanoparticles mediated tumor microenvironment modulation: current advances and applications

et al. 2022

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“…This strategy might also significantly overcome hypoxia-related drug resistance in tumor treatment. Smart NPs were developed to release oxygen depending on O 2 demands, which were triggered by near-infrared light to achieve cooperative photodynamic or photothermal treatment [ 210 ]. These intelligent NPs achieved on-demand and continuous oxygen generation, and excellent accumulation rates and deep intratumor penetration [ 210 ].…”

Section: Using Nanoparticle-based Drug Delivery Systems To Target Tum...mentioning

confidence: 99%

“…Smart NPs were developed to release oxygen depending on O 2 demands, which were triggered by near-infrared light to achieve cooperative photodynamic or photothermal treatment [ 210 ]. These intelligent NPs achieved on-demand and continuous oxygen generation, and excellent accumulation rates and deep intratumor penetration [ 210 ]. In addition, other groups have reported decorated PEG-stabilized PFC nanoparticles.…”

Section: Using Nanoparticle-based Drug Delivery Systems To Target Tum...mentioning

confidence: 99%

Nanoparticle-Based Drug Delivery Systems Targeting Tumor Microenvironment for Cancer Immunotherapy Resistance: Current Advances and Applications

Han

Gong

et al. 2022

Pharmaceutics

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Cancer immunotherapy has shown impressive anti-tumor activity in patients with advanced and early-stage malignant tumors, thus improving long-term survival. However, current cancer immunotherapy is limited by barriers such as low tumor specificity, poor response rate, and systemic toxicities, which result in the development of primary, adaptive, or acquired resistance. Immunotherapy resistance has complex mechanisms that depend on the interaction between tumor cells and the tumor microenvironment (TME). Therefore, targeting TME has recently received attention as a feasibility strategy for re-sensitizing resistant neoplastic niches to existing cancer immunotherapy. With the development of nanotechnology, nanoplatforms possess outstanding features, including high loading capacity, tunable porosity, and specific targeting to the desired locus. Therefore, nanoplatforms can significantly improve the effectiveness of immunotherapy while reducing its toxic and side effects on non-target cells that receive intense attention in cancer immunotherapy. This review explores the mechanisms of tumor microenvironment reprogramming in immunotherapy resistance, including TAMs, CAFs, vasculature, and hypoxia. We also examined whether the application of nano-drugs combined with current regimens is improving immunotherapy clinical outcomes in solid tumors.

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“…[ 15 ] Therefore, the tumor hypoxic microenvironment makes limited cytotoxic ROS to kill cancer cells and decreases the PDT effect, [ 16 ] which has been recognized as a significant obstacle in PDT. [ 17 ] Much work has been done to provide oxygen to tumor sites to alleviate the hypoxic microenvironment, such as increasing oxygen supply by delivering exogenous oxygen with hemoglobin‐based oxygen carriers [ 18 ] and generating oxygen with nanoenzyme in situ. [ 19 ] For instance, Liu et al.…”

Section: Introductionmentioning

confidence: 99%

Engineered Red Blood Cell Membrane‐Coating Salidroside/Indocyanine Green Nanovesicles for High‐Efficiency Hypoxic Targeting Phototherapy of Triple‐Negative Breast Cancer

Pan

Zhao

et al. 2022

Adv Healthcare Materials

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Triple‐negative breast cancer (TNBC) presents special biological behavior and clinicopathological characteristics and leads to a worse prognosis than other types of breast cancer. The development of an effective therapeutic method is significant to improve the survival rate of TNBC cancer patients. In this work, an engineered red blood cell membrane (RBCm)‐coating salidroside/indocyanine green nanovesicle (ARISP) is successfully prepared for hypoxic targeting phototherapy of TNBC. Salidroside in ARISP effectively ameliorates hypoxia‐induced tumorigenesis by downregulating the expression of hypoxia‐inducible factor 1α (HIF‐1α), which increases the killing effect of reactive oxygen species on tumor cells during photodynamic therapy (PDT) using the photosensitizer indocyanine green. Besides, ARISP has an anti‐LDLR modified RBCm‐coating that extends its circulation time in the blood and escapes from immune surveillance and enhances hypoxia‐targeted cellular uptake via the overexpressed LDLR receptor in hypoxic tumor sites. Moreover, guided by near‐infrared fluorescence imaging and photoacoustic imaging, ARISP can eliminate tumors via high‐efficiency phototherapy and inhibit lung and liver metastasis in TNBC models. Cytotoxicity assay of ARISP indicates the excellent biocompatibility with normal cells and tissues. This study provides fulfilling insights into the anticancer mechanism of reducing HIF‐1α for enhanced PDT and has a promising therapeutic potential for TNBC treatment.

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An all-in-one nanoplatform with near-infrared light promoted on-demand oxygen release and deep intratumoral penetration for synergistic photothermal/photodynamic therapy

Cited by 9 publications

References 42 publications

Nanoparticles mediated tumor microenvironment modulation: current advances and applications

Nanoparticles mediated tumor microenvironment modulation: current advances and applications

Nanoparticle-Based Drug Delivery Systems Targeting Tumor Microenvironment for Cancer Immunotherapy Resistance: Current Advances and Applications

Engineered Red Blood Cell Membrane‐Coating Salidroside/Indocyanine Green Nanovesicles for High‐Efficiency Hypoxic Targeting Phototherapy of Triple‐Negative Breast Cancer

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