An alginate/poly(N-isopropylacrylamide)-based composite hydrogel dressing with stepwise delivery of drug and growth factor for wound repair

Lin, Xilin; Guan, Xipeng; Wu, Youheng; Zhuang, Shuqiang; Wu, Yuzheng; Du, Lin; Zhao, Jiafeng; Rong, Jian; Zhao, Jianhao; Tu, Mei

doi:10.1016/j.msec.2020.111123

Cited by 65 publications

(42 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Based on previous studies ( Lin et al, 2020 ), the effect of hydrogels on wound healing in vivo was evaluated in a full-thickness burn rat model for up to 21 days. Animal experiments were performed according to the approval of the Animal Ethics Committee of Jinan University, in accordance with relevant laws and institutional guidelines.…”

Section: Methodsmentioning

confidence: 99%

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

et al. 2021

View full text Add to dashboard Cite

Overexpression of reactive oxygen species (ROS) can lead to chronic inflammation, which limits skin wound healing. Therefore, it is of great significance to develop materials that can locally control the adverse reactions caused by excessive ROS. In this research, an ROS-sensitive hydrogel with strong free radical scavenging ability was prepared by introducing the thione (Tk) group into carboxymethyl chitosan (CMCTS) hydrogel. CMCTS hydrogel was cross-linked by NH2-Tk-NH2 agent and loaded curcumin (Cur), which possessed favorable nontoxicity, water absorption, mechanical property, biodegradability, drug release behavior, the M2 phenotype, and inflammatory factor regulating the capacity of macrophages. It is worth noting that Cur@CMCTS-Tk hydrogel can significantly inhibit oxidative damage of human fibroblasts in the H2O2-induced microenvironment and protect their viability by reducing the production of intracellular ROS. In vivo, ROS-removing hydrogel effectively accelerated the process of wound healing and possessed good regenerative properties, including hair follicle formation, promotion of new blood vessel formation, and highly orderly arrangement of collagen fibers in the full-thickness skin burn defect rat model. Hence, we expect that the Cur@CMCTS-Tk hydrogel could be used for wound treatment and tissue regeneration due to the ability to scavenge excess ROS.

show abstract

Section: Methodsmentioning

confidence: 99%

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Nanotechnologies have been used in dressings for growth factor incorporation, ameliorating growth factors bioavailability and stability. According experimental studies, EGF and FGF- incorporated dressings accelerate angiogenesis, extracellular matrix remodeling and re-epithelialization, with great potential in skin wound treatment [ 87 , 88 , 89 , 90 , 91 , 92 ].…”

Section: Wound Treatmentsmentioning

confidence: 99%

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

Gushiken

Beserra

Bastos

et al. 2021

Life

126

View full text Add to dashboard Cite

The skin is the biggest organ of human body which acts as a protective barrier against deleterious agents. When this barrier is damaged, the organism promotes the healing process with several molecular and cellular mechanisms, in order to restore the physiological structure of the skin. The physiological control of wound healing depends on the correct balance among its different mechanisms. Any disruption in the balance of these mechanisms can lead to problems and delay in wound healing. The impairment of wound healing is linked to underlying factors as well as aging, nutrition, hypoxia, stress, infections, drugs, genetics, and chronic diseases. Over the years, numerous studies have been conducted to discover the correct approach and best therapies for wound healing, including surgical procedures and non-surgical treatments such as topical formulations, dressings, or skin substitutes. Thus, this general approach is necessary to facilitate the direction of further studies. This work provides updated concepts of physiological mechanisms, the factors that can interfere, and updated treatments used in skin wound healing.

show abstract

“…pH 响应性水凝胶，即能够通过调控 pH 来控制药物释放的水凝胶。海藻酸盐在酸性 pH 下交联形成水凝胶，而在碱性和中性 pH 时溶胀，交联断裂 [42] 。因此可以通过调节 pH 使海藻酸盐发生不同程度的溶胀，然后按需释放药物。研究发现，pH=1.2 时牛血清白蛋白能够从羧甲基壳聚糖-海藻酸盐水凝胶中释放，但其释放速度远低于 pH=7.4 时 [43] 。这与海藻酸盐水凝胶在 pH =1.2 时的低溶胀率有关，当 pH=7.4 时，水凝胶的孔隙率，从而导致酸性 pH 下的药物释放小于中性 pH [43] 。人体消化系统中的 pH 变化，也适用于海藻酸盐水凝胶中药物的可控释放。当其经过胃部时，由于此时 pH =1.2，所以海藻酸盐水凝胶紧密结合，孔隙率低，其中封装的物质不易释放 [44] 。而后经过小肠，此时 pH 呈中性，所以海藻酸盐水凝胶溶胀，结构被破坏，药物可以轻易从水凝胶孔隙中释放 [45] 。肼和羰基化合物能够生成腙及其成环化合物，相较于中性条件，其在酸性条件下具有更快的水解速率，因而常被用于药物递送 [46] [47] 炎症反应，并加速了感染区域的愈合过程 [48] 。图 4 pH 响应的海藻酸盐水凝胶递送小分子药物示意图 [48] 。 Figure Schematic diagram of pH-responsive alginate hydrogel to deliver small molecule drugs [48] .…”

Section: Ph 响应性水凝胶unclassified

“…伤口愈合是一个复杂且持续的过程，受多个因素影响，适当环境下可以加快伤口愈合速度。伤口愈合过程可分为三个重叠的阶段即炎症，新组织生成和重塑 [63] 。当伤口处于湿润而非潮湿的环境时，上皮细胞从伤口边缘到受伤区域的迁移要快于伤口处于干燥状态时的细胞迁移。现代"湿疗法"伤口敷料旨在创造一种湿润的环境以达到最佳的治疗效果，其愈合伤口的速度是干法的 3-5 倍 [64] 。基于海藻酸盐的水凝胶是应用于伤口愈合的理想材料 [65] 。其中海藻酸盐可以为伤口提供潮湿的微环境，促进重新上皮化和肉芽组织的形成，从而加快伤口闭合 [66] [44,68]…”

Section: 作为递送载体用于伤口愈合unclassified