An aggressive form of non-Hodgkin's lymphoma with pleural and abdominal chylous effusions: A case report and review of the literature

Jiang, Yajian; Xie, Wanzhuo; Hu, Keyue; Sun, Jie; Zhu, Xiaoli; Huang, He

doi:10.3892/ol.2013.1501

Cited by 10 publications

(10 citation statements)

References 21 publications

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“…Recently, the data of lymphoid neoplasms in effusions are lacking from many parts of the world. It has been reported mostly as single case description or in reviews of multiple case reports from different institutions [20][21][22][23][24]. To the best of our knowledge, this study is the largest series of lymphoid neoplasms in effusions reported from China.…”

Section: Discussionmentioning

confidence: 97%

Clinical and cytopathologic characteristics of lymphoid neoplasms involved with serous effusions: a single center experience

Gong

Shao

et al. 2020

Preprint

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Background: Lymphoid neoplasms in serous effusions (SEs) were uncommon. Currently, most reports of lymphoid neoplasms in SEs were from Western countries, but few reports were from China, and the details were still unclear. Methods: Between January 2004 and December 2019, lymphoid neoplasms diagnosed by cytological methods from specimens of pleural effusions (PEs), ascites, and pericardial effusions in our hospital were reviewed.Results: 59 patients of lymphoid neoplasms were diagnosed by SEs, the top three causes were diffuse large B-cell lymphoma (DLBCL) (n=21, 35.6%), myeloma (n=13, 22.0%), and T-lymphoblastic lymphoma (n=5, 8.5%). In PEs involved with DLBCL, the cytomorphology of DLBCL cells was variable, most PEs were present during tumor course (92.9%), bilateral PEs were the predominance (57.2%), and the median survival time was only 1.23 months after effusion. In PEs involved with myeloma, nearly all cases had a high ratio of immature to mature plasma cells (>1.0), IgA (36.4%) and light chain λ (36.4%) were the most frequently found. Bilateral PEs were easily found (90.9%), and the median survival time was only 1.4 months after effusion. Solitary plasmacytomas with myeloma infiltration in PEs seemed to have a better prognosis than that of plasma cell myeloma.Conclusion: Some differences are found between our patients and those from Western countries, and more studies involving different ethnic populations could help to elucidate the features of lymphoid neoplasms in SEs.

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Section: Discussionmentioning

confidence: 97%

Clinical and cytopathologic characteristics of lymphoid neoplasms involved with serous effusions: a single center experience

Gong

Shao

et al. 2020

Preprint

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“…Malignant pericardial effusion associated with NHL may represent direct malignant infiltration, effusive-constrictive pericarditis secondary to radiation therapy, invasion of the pericardial space with opportunistic pathogens or an inflammatory effusion secondary to chemotherapy [ 2 , 5 ], as we suspect was the case in our patient after his third effusion recurrence. In two-thirds of cases, pericardial effusion is a benign complication, and not an extension, of malignancy [ 6 ]. A lymphocyte-rich effusion may represent a reactive lymphocytosis indistinguishable from malignancy, but this equivocal yield can be overcome by using morphometry with 85% sensitivity and 95% specificity [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Swinging heart caused by diffuse large B-cell lymphoma

Montañez-Valverde

Olarte

Zablah

et al. 2018

Oxford Medical Case Reports

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Pericardial disease is a common complication of solid tumors and occasionally seen in hematologic malignancies. Pericardial effusion, when it occurs, is usually caused by tumor seeding of the pericardium leading to a serous effusion or by mass effect from mediastinal lymphadenopathy blocking drainage of lymphatic ducts. Pericardial disease from non-Hodgkin’s lymphoma is uncommon and malignant pericardial effusion is even rarer. Here we present a case of a 31-year-old male with diffuse large B-cell lymphoma who developed cardiac tamponade from a malignant pericardial effusion.

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“…Pleural fluid cytology also showed that the fluid was a metastasis from lymphoma cells into the pleuralspace. 18 The diagnosis of a high risk of venous thromboembolism (VTE) in patients is based on Padua scoring the total score of 9. This patient should be given prophylactic heparin but considering that the patient has thrombocytopenia so it cannot be given.…”

Section: Case Reportmentioning

confidence: 99%

Diffuse large B-cell lymphoma in a patient with chronic myelogenous leukemia on accelerated phase with bilateral pleural effusion: a case report

Zukhrufan¹,

Faheri²

2020

Int J Res Med Sci

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Chronic Myelogenous Leukemia (CML) is a myeloproliferative disorder of pluripotent stem cells. The pathogenesis of CML is known to be related to mutations in the form of Philadelphia chromosomes. The incidence of CML constitutes 20% of all cases of leukemia in adults. The current gold standard for CML therapy is using tyrosine kinase inhibitors (TKI), Imatinib. Non-Hodgkin Lymphoma (NHL) is a malignancy that develops from lymph nodes. In NHL the formation of malignant cells is in the form of lymphocytes that are at one of the differentiation levels of either T lymphocytes or B lymphocytes. Diffuse large B cell lymphoma is the most common NHL, representing about 40% of all lymphoma cases. NHL management is targeted chemotherapy using rituximab combined with cyclophosphamide, doxorubicine, vincristine and prednisone. A Thirty-four year-old female patient has been reported with the main complaint of fatigue and pale weakness accompanied by an enlarged abdomen. Complaints are also accompanied by a lump in the right neck, fever, productive cough and shortness of breath. The patient has been known to suffer from CML with BCR-ABL (+) since five years ago and received Imatinib therapy, but then the patient stopped treatment himself. On physical examination found anemic, multiple enlargement of the neck lymph nodes, wet crackles soft and loud in the basal of both lungs and splenomegaly. On investigations found severe anemia, thrombocytopenia and blast 13%, increased d-dimer, bronchopneumonia-compliant infiltrate and bilateral pleural effusion on chest x-ray, results of exudate pleural fluid analysis with the cytology of a malignant smear metastasis of lymphoma to the pleura, histopathology of the neck lymph nodes with chest x-ray, analysis of exudate pleural fluid with the cytology of a malignant smear metastasis of lymphoma into the pleura, histopathology of the neck lymph nodes with the results of diffuse large B-Cell lymphoma, as well as enlargement of paraaortic lymph nodes, hepatosplenomegaly and chronic pancreatitis on abdominal ultrasound. Patients was given antibiotics, transfusion of packed red cells and platelets, pleural tap and chemotherapy. The patient was planned to undergo chemotherapy for 6 cycles of 21 days, and a CD20 examination was performed. The incidence of NHL in patients with good CML in imatinib therapy is not yet certain whether there is a direct relationship.

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An aggressive form of non-Hodgkin's lymphoma with pleural and abdominal chylous effusions: A case report and review of the literature

Cited by 10 publications

References 21 publications

Clinical and cytopathologic characteristics of lymphoid neoplasms involved with serous effusions: a single center experience

Clinical and cytopathologic characteristics of lymphoid neoplasms involved with serous effusions: a single center experience

Swinging heart caused by diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma in a patient with chronic myelogenous leukemia on accelerated phase with bilateral pleural effusion: a case report

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