An afferent hippocampal fiber system in the fornix of the monkey

Votaw, Charles L.; Lauer, Edward W.

doi:10.1002/cne.901210205

Cited by 24 publications

(12 citation statements)

References 36 publications

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“…Furthermore, right-left theta band coherence (Ͼ0.75) typically peaked after the right-sided onset, suggesting that epileptic activity spread to the left hippocampus during this time, where it continued independently. The lag time of 23.6 Ϯ 2.8 ms observed in seizure theta synchronization between right and left hippocampal LFPs is consistent with interhemispheric delay of ϳ25 ms (Queiroz and Mello 2007;Votaw and Lauer 1963). Administration of ketamine caused a marked increase in LFP power selectively in the right hippocampus and consistently gave rise to seizures.…”

Section: Discussionsupporting

confidence: 74%

Sensing-enabled hippocampal deep brain stimulation in idiopathic nonhuman primate epilepsy

Lipski

DeStefino

Stanslaski

et al. 2015

Journal of Neurophysiology

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-Epilepsy is a debilitating condition affecting 1% of the population worldwide. Medications fail to control seizures in at least 30% of patients, and deep brain stimulation (DBS) is a promising alternative treatment. A modified clinical DBS hardware platform was recently described (PCϩS) allowing long-term recording of electrical brain activity such that effects of DBS on neural networks can be examined. This study reports the first use of this device to characterize idiopathic epilepsy and assess the effects of stimulation in a nonhuman primate (NHP). Clinical DBS electrodes were implanted in the hippocampus of an epileptic NHP bilaterally, and baseline local field potential (LFP) recordings were collected for seizure characterization with the PCϩS. Real-time automatic detection of ictal events was demonstrated and validated by concurrent visual observation of seizure behavior. Seizures consisted of large-amplitude 8-to 25-Hz oscillations originating from the right hemisphere and quickly generalizing, with an average occurrence of 0.71 Ϯ 0.15 seizures/day. Various stimulation parameters resulted in suppression of LFP activity or in seizure induction during stimulation under ketamine anesthesia. Chronic stimulation in the awake animal was studied to evaluate how seizure activity was affected by stimulation configurations that suppressed broadband LFPs in acute experiments. This is the first electrophysiological characterization of epilepsy using a next-generation clinical DBS system that offers the ability to record and analyze neural signals from a chronically implanted stimulating electrode. These results will direct further development of this technology and ultimately provide insight into therapeutic mechanisms of DBS for epilepsy. deep brain stimulation; hippocampus; temporal lobe epilepsy; local field potential EPILEPSY IS A COLLECTION of diverse disorders, varying in pathogenesis, site of seizure onset, and response to treatment. Temporal lobe epilepsy (TLE) is a common form of the disorder, characterized by seizures originating in the temporal lobe, most frequently in the hippocampus and amygdala. In cases where pharmacological therapy either fails to adequately control seizures or is not well tolerated, resective surgery is an effective treatment, suppressing disabling seizures in 50 -80% of patients undergoing mesial TLE (MTLE) resections (Engel et al. 2003). Seizure freedom occurs in fewer than 50% of patients undergoing extratemporal resections (de Tisi et al. 2011), however, and resective surgery is not an option for cases where the seizure focus is not well localized or when resection would cause unacceptable functional deficits. These problems, coupled with the nonreversible nature of resective surgery, underscore the need for new and more effective alternative treatments for medically refractory epilepsy. Deep brain stimulation (DBS) is a promising emerging therapy for focal epilepsy. Most efforts to date have focused on modulating nodes within the limbic circuit of Papez, a network often implica...

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Section: Discussionsupporting

confidence: 74%

Sensing-enabled hippocampal deep brain stimulation in idiopathic nonhuman primate epilepsy

Lipski

DeStefino

Stanslaski

et al. 2015

Journal of Neurophysiology

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“…In first observing the ipsilateral prefronto-hippocampal projection, it was thought that our prefrontal ablations might have impinged on the sep tum, which is known to give rise to an efferent projection that reached the hippocampus through both the fornix and longitudinal striae [4,26]. Yet even in the most well-circumscribed superficial lesions, clearly rostral to the septal region (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Further, it has been demonstrat ed that the prefrontal cortex sends direct projections through the cingul um and uncinate fascicle to the entorhinal cortex [11,20,24], which is considered as the principal source of direct afferents, and thus the 'gate way', to the hippocampus [1]. The question arises, however, as to wheth er there might be other areas, in addition to the entorhinal area [24], sep tum [4,26] and possibly the cingulate gyrus [1, 6,19], which give rise to direct input to Ammon's horn.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Evidence for a Direct Projection of the Prefrontal Cortex to the Hippocampus in the Squirrel Monkey

Leichnetz¹,

Astruc²

1975

Brain Behav Evol

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Unilateral partial ablations in the medial prefrontal cortex of six squirrel monkeys led to fiber degeneration which followed cingulate and uncinate routes to the hippocampal region. Degenerating fibers were observed primarily in the alvear, but also in the perforant, bundle. Preterminal and terminal debris was seen on basket cells of the stratum oriens and pyramidal cells within the stratum pyramidalis of CA _1–3, Since the prefrontal cortex has been shown to receive convergent sensory inputs from both external and internal milieu, this projection may represent the anatomical substrate for the essential influence of this information on the hippocampus proper, and also explain data which show the prefrontal cortex and hippocampus to be integrally related to mechanisms of learning and memory behavior.

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“…WE should like to thank the following scientists for permission to use material from their publications: P. Andersen Allen 1944Simpson 1952Sprague and Meyer 1950 McLardy 1955bPowell and Cowan 1955Guillery 1956Nauta 1956Powell et al 1957 Nauta 1958Johnson 1959Valenstein and Nauta 1959Votaw 1960aPowell 1963Votaw and Lauer 1963a Johnson 1965Raisman et al 1966Raisman 1969 Van Buren 1970De France et al 1971Hjorth-Simonsen 1971Siegel and Tassoni 1971aPepeu et al 1973Segal and Landis 1974Siegel et al 1974Meibach and Siegel 1975Swanson and Cowan 1975a,b * Flynn and Wassman 1960Akert and Gernandt 1962Feldman 1962 Parmeggiani 1962 Cazard and Buser 1963Fox et al 1967Gergen 1967 Parmeggiani 1967Redding 1967Yamaguchi et al 1967Sierra and Fuster 1968Vanegas and Flynn 1968Yokota and MacLean 1968 Parmeggiana and Rapisarda 1969 Redding 1969Ungher et al 1969Kerr and Dennis 1970Poletti et al 1970 Golden and Lobar 1971Grillo 1971Kaada et al 1971 Bland and Vanderwolf 1972b, De France et al 1972Grantyn et al 1972McKenzie and Gilbert 1972Andersen et al 1973…”

Section: Acknowledgementsmentioning

confidence: 99%

“…Anatomical studies of the septal afferents to the hippocampus Daitz and Powell 1954McLardy 19551a Cragg and Hamlyn 1957* Votaw 1960bPowell 1963Votaw and Lauer 1963a Alksne and Blackstad 1965Raisman et al 1965Anden et al 1966De Vito and White 1966Petsche, Gogolak, and Stumpf 1966 *, ** Raisman 1966 Lewis and Shute 1967 Genton 1969 Storm- Mathisen 1970Ibata et al 1971Siegel and Tassoni 1971b ** Storm-Mathisen and Fonnum 1972 Hjorth- Simonsen 1973Mosko et al 1973Sethy et al 1973Srebro et al 1973Mellgren and Srebro 1973Oderfeld-Nowak et al 1974Segal and Landis 1974Srebro and Mellgren 1974 Storm-Mathisen and Guldberg 1974 * Combined electrophysiological and histological study. * * Indicates disagreement with majority of studies that septo-hippocampal projection originates in the medial septum and diagonal band of Broca.…”

Section: Appendix Appendix Table A1 (A)mentioning

confidence: 99%