An adrenergic mechanism for hyperglycemia induced by diazoxide

Diazoxide effects on biphasic insulin release: “adrenergic” suppression and enhancement in the perifused rat pancreas

“…The extrapancreatic effects have been attributed to diazoxide-induced increase in circulating catecholamines (12)(13)(14). This conclusion is supported by the reported inhibition of diazoxide hyperglycemia by prior adrenalectomy and by the administration of adrenergic receptor-blocking agents (11,(15)(16)(17), although other extrapancreatic effects not mediated via the catecholamine response may exist (18).…”

“…It would appear that this hyperglycemic ac-tion is exerted through both pancreatic (6)(7)(8)(9) and extrapancreatic effects (10,11). The extrapancreatic effects have been attributed to diazoxide-induced increase in circulating catecholamines (12)(13)(14).…”

Benzothiadiazine suppression of insulin release from normal and abnormal islet tissue in man.

“…It has been suggested that adrenergic influences may constitute a significant component of benzothiadiazine hyperglycemia (9,11,25) and that potassium changes merely alter the sensitivity of sympathetic nerve elements or receptors (11). Increased release of catecholamines or increased catecholamine activity might explain part of the extrapancreatic hyperglycemic effect of this series of compounds.…”

Drugs Acting on Arteriolar Smooth Muscle (Vasodilator Drugs)

“…A rise in plasma glucose level in dogs was already seen with the infusion of 15 mg/kg (SAUBAR et al, 1967). It was suggested by some authors that the hyperglycemic response was related to the lowering of blood pressure, and this hypothesis was supported by the finding that sodium nitroprusside induced an increase in blood sugar levels when given in doses that elicited a comparable fall in blood pressure (STAQUET et al, 1965). However, no other reports on a hyperglycemic response to sodium nitroprusside have been published so far, nor has the drug a hyperglycemic effect in man that is comparable to that of diazoxide.…”