An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation

Chen, Jing; Caserto, Julia S.; Ang, Ida; Shariati, Kaavian; Webb, James; Wang, Bo; Wang, Xi; Bouklas, Nikolaos; Ma, Minglin

doi:10.1016/j.bioactmat.2021.11.038

Cited by 22 publications

(31 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastric perforation would cause severe peptic ulcer disease, resulting in several complications. [ 41 ] Given the ex vivo sealing efficacy and biological safety (Figure S17c, Supporting Information), we then performed an SD rats' full‐thickness gastric perforation model and a rabbit's lung leakage model to provide insight into clinical applications. After the gastric wound was established, the mucosal layer was evidently everted out, with gastric acid flowing away ( Figure a).…”

Section: Resultsmentioning

confidence: 99%

Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing

Liu

Yang

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Hydrogel adhesives are hot spots due to their ubiquity and practical relevance. However, achieving a robust wet adhesion is still a challenge due to the preferential formation of hydrogen bonds between interfacial fluids and bulk hydrogel, as well as targeted substrates. Herein, a half‐dry adhesive consisting of a silk fibroin (SF) semi‐interpenetrating network and poly(acrylic acid) covalent network, which can allow a rapid liquid adsorption and repulsion process encountering a wet tissue, is reported. The remaining water enables excellent hydrogel flexibility to a dynamic surface, while the β‐sheet fold endows its tough bulk strength under the peeling‐off process. Notably, the wet adhesion energy versus porcine skin is 1440 J m−2 due to the combination of hydrogen bonds, electrostatic interactions, and chain entanglement derived from SF. In particular, both in vitro and in vivo outcomes indicate excellent hemostatic effects and result in incision closure of skin, artery, gastric perforation, and lung. After the first‐stage closure, polyacrylic‐silk fibroin adhesive (PSA) sealants can detach from the lung surface, fitting well to the healing period. By virtue of the reliable adhesion and good noncytotoxicity, PSA may be a prospective candidate for tissue sealant and drug carrier applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing

Liu

Yang

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Other studies [ 74 , 91 ] have revealed that fiber weight affects a hemostat’s time to achieve hemostasis ( Figure 4C ). Similar studies have shown that fiber diameter affects resultant mechanical properties such as Young’s modulus, stress, strain, and toughness ( Figure 4D ).…”

Section: Micro/nanostructures In Hemostatic Applicationmentioning

confidence: 86%

“…These factors mentioned above can also be applied to developing and applying a sequential drug delivery system for bioactive factors during hemostasis and wound healing using the inherent properties of micro/nanostructures [ 72 , 73 ] . Hydrogels incorporated with micro/nanostructures are used to assist in the on-demand delivery of drugs in the form of small molecules, proteins, and various nanoparticles [ 74 , 75 ] .…”

Section: Structural and Functional Prospect Of Biomaterials At Bioint...mentioning

confidence: 99%

“…Controlled release via micro/nanostructures’ stimulus responsivity is significant to hemostasis and wound healing because stimuli external to the ECM, such as 362 electrical, light, and ultrasound stimulations, play a role in determining stem cell behavior [ 44 , 74 ] . Topographical modifications can modulate monocyte attachment and macrophage differentiation.…”

Section: Structural and Functional Prospect Of Biomaterials At Bioint...mentioning

confidence: 99%

“…Electrospinning techniques are also widely used and valued for their submicron precision in fabrication in the design of various hemostatic agents [ 67 ] . Submicron precision in design is necessary because tunable factors, such as morphology, mechanical, electrical, and magnetic stimulations, influence the type and extent of cell-substrate interactions in micro/nanostructures [ 74 ] . Therefore, electrospinning techniques can be used as a micro/ nanostructure fabrication method, which is a biomimetic approach to hemostasis and wound healing to inhibit undesirable side effects optimally [ 45 ] .…”

Section: Micro/nanostructures In Hemostatic Applicationmentioning

confidence: 99%

See 2 more Smart Citations

Multifunctional 3D platforms for rapid hemostasis and wound healing: Structural and functional prospects at biointerfaces

Ganguly¹,

Espinal²,

Dutta³

et al. 2022

IJB

View full text Add to dashboard Cite

Fabrication of multifunctional hemostats is indispensable against chronic blood loss and accelerated wound healing. Various hemostatic materials that aid wound repair or rapid tissue regeneration has been developed in the last 5 years. This review provides an overview of the three-dimensional (3D) hemostatic platforms designed through the latest technologies like electrospinning, 3D printing, and lithography, solely or in combination, for application in rapid wound healing. We critically discuss the pivotal role of micro/nano-3D topography and biomaterial properties in mediating rapid blood clots and healing at the hemostat-biointerface. We also highlight the advantages and limitations of the designed 3D hemostats. We anticipate that this review will guide the fabrication of smart hemostats of the future for tissue engineering applications.

show abstract

Injectable‐Hydrogel‐Based Tissue Sealant for Hemostasis, Bacteria Inhibition, and Pro‐Angiogenesis in Organ Bleeding Wounds and Therapeutic Outcome Monitoring Via NIR‐II Optical Imaging

Sun,

Ouyang,

She

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Sudden hemorrhage stemming from internal organ wounds poses a grave and potentially fatal risk if left untreated. Injectable‐hydrogel‐based tissue sealants featuring multiple actions, including fit‐to‐shape in‐situ gelation, rapid hemostasis, pro‐angiogenic, anti‐bacterial and outcome tracking, are ideal for the management of organ trauma wounds. Herein, we have developed an injectable‐hydrogel tissue sealant AN@CD‐PEG&TQ which consists of 4‐arm PEG‐SC, AN@CD nanoprobe and two bioactive peptides (anti‐microbial peptide Tet213 and pro‐angiogenic peptide QK). Among them, AN@CD nanoparticles form through host/guest complexation of amino‐group‐containing β‐cyclodextrin and adamantyl group, enabling in‐situ biomarker (NO)‐activatable optoacoustic/NIR‐II fluorescent imaging. The ample ‐NH2 groups on the surface of AN@CD readily engage in rapid cross‐linking with succinimidyl ester groups located at the ends of 4‐arm PEG‐SC. This cross‐linking expedites the gelation process without necessitating additional initiators or cross‐linking agents, thus significantly enhancing both hydrogel's application convenience and biocompatibility. Bioactive peptides (Tet213 and QK) safeguard against possible bacterial infections and facilitate angiogenesis and eventually improve organ wounds healing. This hydrogel‐based tissue sealant demonstrates superior therapeutic and bioimaging performance in various mouse models including liver hemorrhage, gastric perforation and bacterial‐infected skin wound mouse models, highlighting its potential as a high‐performance wound sealant for organ bleeding wound management.This article is protected by copyright. All rights reserved

show abstract

An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation

Cited by 22 publications

References 41 publications

Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing

Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing

Multifunctional 3D platforms for rapid hemostasis and wound healing: Structural and functional prospects at biointerfaces

Injectable‐Hydrogel‐Based Tissue Sealant for Hemostasis, Bacteria Inhibition, and Pro‐Angiogenesis in Organ Bleeding Wounds and Therapeutic Outcome Monitoring Via NIR‐II Optical Imaging

Contact Info

Product

Resources

About