An additional younger‐age peak for cancer of the nasopharynx

Balakrishnan, Vijay Shankar

doi:10.1002/ijc.2910150414

Cited by 31 publications

(24 citation statements)

References 9 publications

(8 reference statements)

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“…Race was a second variation compared to the literature; most of the patients were Caucasian, and there were no patients of Asian origin. 12,13 These findings coincide with those of the National Cancer Institute (USA), showing a higher incidence of nasopharyngeal carcinomas in young adult Caucasians and Afro-Americans compared to Asian patients. 14 Tobacco and alcohol are relevant etiological factors in upper digestive airways.…”

Section: Discussionsupporting

confidence: 86%

Avaliação dos fatores clínicos e do tratamento em pacientes com carcinoma indiferenciado da nasofaringe

Chedid

Franzi

Dedivitis

2008

Rev. Bras. Otorrinolaringol.

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The nasopharyngeal carcinoma (NPC) is a rare cancer with a high incidence in Southern Asia. Aim: to study the demographic, clinical, therapeutic, and prognostic factors of nasopharyngeal undifferentiated carcinoma in a reference service. Materials and methods: A retrospective study was made of 46 patients from January 1998 to August 2000. The patients had no previous treatment and did not present any evidence of synchronous tumors or distance metastases. Results: The age ranged from 14 to 78 years (mean = 46 years); 35 (76%) patients were male. All patients were Caucasian or African-Brazilian. The onset of initial symptoms ranged from 1 to 48 months (mean = 7 months); 47% of the subjects smoked tobacco and 33% consumed alcoholic beverages. A lump in the neck was the most frequent symptom (34 patients). Twenty-two patients were clinically staged as T1/T2 and 24 patients as T3/T4; 24 patients were classified as N2, and 16 patients were staged as N3. Curative treatment consisted of radiotherapy and simultaneous chemotherapy in clinical stages III and IV. Of 27 patients that were monitored, 52% were alive with no evidence of disease after three years. Conclusion: All patients were in advanced clinical stages of the disease. The three-year disease-free survival rate was 52%.

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Section: Discussionsupporting

confidence: 86%

Avaliação dos fatores clínicos e do tratamento em pacientes com carcinoma indiferenciado da nasofaringe

Chedid

Franzi

Dedivitis

2008

Rev. Bras. Otorrinolaringol.

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“…While the existence of a "middle aged" peak is consistent with findings in the literature, the existence and significance of a second peak at an earlier age is more speculative. Second smaller peaks have been reported for patient populations in Bombay, India, 13-22 years; 6 Puerto Rico, 20-24 years; 7 and Tunisia, 10-19 years. 8 The geographic distribution of referred cases of nasopharyngeal cancer to KFSH should not necessarily be interpreted as an indication of geographic variation in the incidence of the disease.…”

Section: Discussionmentioning

confidence: 92%

Nasopharyngeal Carcinoma in Saudi Arabia: Selected Clinical and Epidemiological Aspects

et al. 1990

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A retrospective review of 381 patients with histologically confirmed nasopharyngeal carcinoma referred from all regions of Saudi Arabia to the King Faisal Specialist Hospital and Research Centre during the 10½-year period (June 1975 to December 1985 demonstrated a high frequency of stage IV tumors (93%), with 17.3% having distant metastases at presentation. There was a very low incidence (2%) of keratinizing squamous cell carcinoma, considered due to the relatively young age of the population. Age analysis indicated a peak incidence among the referred cases in the 45-55 age group, with a smaller peak in the 20-24 age group for both males and females, although the younger age peaks were reduced when the patient numbers were standardized for available population census figures.

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“…NPC is uncommon in the Indian subcontinent except in the Northeastern part of the country [9]. The incidence of NPC is low in Indians (\1 per 100,000 per year) [10], with young age peak in second decade [11] both of which are comparable to UK [1].…”

Section: Introductionmentioning

confidence: 99%

“…The age distribution is similar in both genders. The incidence rates in male populations are commonly two to three fold that of female populations [2,4,[11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Nasopharyngeal Carcinoma: A 15 Year Study with Respect to Clinicodemography and Survival Analysis

Wani

Khan

Wani³

et al. 2016

Indian J Otolaryngol Head Neck Surg

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Nasopharyngeal carcinoma (NPC) is a rare malignancy in Kashmir with distinct pattern, hence we planned to study its clinicodemographic and survival profile. Kashmir has unique lifestyle and dietary habits which may be the source of carcinogenic compounds, most likely implicated in causation of NPC. A total of 148 patients of NPC registered from January 2000 to December 2014 were analyzed. The Mean ± SD age was 45.15 ± 17.092 years (range 11-85 years). The males were 72.3 % (N = 107) with male: female ratio of 2.61:1. Most of the patients were from rural area 81.90 % (N = 95) and non-smokers were 53.44 % (N = 62). Neck swelling was commonest presentation. WHO Type III NPC was commonest histopathological diagnosis 65.3 % (N = 92). Stage IV 36.1 % (N = 51) was commonest stage followed by stage III was 32 % (N = 46). Majority of the patients of NPC received CCRT 68.7 % (N = 78) followed by SCRT 13 % (N = 15) and Induction ? CCRT 13 % (N = 15). The overall mean survival of NPC was 49.56 months. There was no significant correlation of age, gender, smoking, histopathology and treatment on the overall survival. However the stage was the only strong predictor of overall survival. Also the patients with intracranial extension had low survival which is turn depicts the advanced stage of disease. NPC survival is directly related to the stage of the disease irrespective of the treatment modality received. The negative EBV status in our patients implies that there are other risk factors involved in the causation of NPC for which further studies are needed to establish the etiological insult.

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An additional younger‐age peak for cancer of the nasopharynx

Cited by 31 publications

References 9 publications

Avaliação dos fatores clínicos e do tratamento em pacientes com carcinoma indiferenciado da nasofaringe

Avaliação dos fatores clínicos e do tratamento em pacientes com carcinoma indiferenciado da nasofaringe

Nasopharyngeal Carcinoma in Saudi Arabia: Selected Clinical and Epidemiological Aspects

Nasopharyngeal Carcinoma: A 15 Year Study with Respect to Clinicodemography and Survival Analysis

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