An Adaptable Peptide-Based Porous Material

Rabone, Jeremy; Yue, Ye; Chong, Samantha Y.; Stylianou, Kyriakos C.; Bacsa, John; Bradshaw, Darren; Darling, George R.; Berry, Neil G.; Khimyak, Yaroslav Z.; Ganin, Alexey Y.; Wiper, Paul V.; Claridge, John B.; Rosseinsky, M. J.

doi:10.1126/science.1190672

Cited by 361 publications

(292 citation statements)

References 32 publications

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“…The silver ion concentration in supernatant solution was determined by cathodic stripping voltammetry. It was shown that materials (1) (Ag3(4-PO3-C6H4-COO), which exhibited the more compact structure released only traces of silver ions in solution while materials (2) (Ag (4-PO3H-C6H4-COOH) and (3) (Ag(3-PO3H -C6H4-COOH)), characterized by the presence of free carboxylic acid functional 19 groups in their structure, released more easily silver salts in water. These results, concomitantly with the silver release capacity of material (4) previously reported, clearly show that the silver release is dictated by the topology of the hybrid.…”

Section: Resultsmentioning

confidence: 99%

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Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

et al. 2015

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(Word Style "BD_Abstract").Three novel silver-based Metal Organic Frameworks materials which were synthesized from either 3-phosphono or 4-phosphonobenzoic acid and silver nitrate are reported. The novel hybrids were synthesized under hydrothermal conditions; the pH of the reaction media was controlled by adding different quantities of urea thereby producing different topologies.Compound 1 (Ag3(4-PO3-C6H4-COO)), synthesised in presence of urea, exhibits a compact 3D structure in which both phosphonic acid and carboxylic acid functional groups are linked to the silver-based inorganic network. Compound 2 (Ag(4-PO3H-C6H4-COOH)), which was synthesized at lower pH (without urea), has a layered structure in which only the phosphonic acid functional groups from 4-phosphonobenzoic acid moieties are linked to the silver inorganic network; the carboxylic acid groups being engaged in hydrogen bonds. Finally, material 3 (Ag(3-PO3H-C6H4-COOH)) was synthesised from 3-phosphonobenzoic acid and silver nitrate without urea. This material 3 features a layered structure exhibiting carboxylic acid functional groups linked via hydrogen bonds in the interlayer space. After the full characterization of these materials (single X-ray structure, IR, TGA), their ability to release silver salts in aqueous environment was measured. Silver release, determined in aqueous solution by cathodic stripping voltammetry, shows that the silver release capacity of these materials is dependent on the topology of the hybrids. The more compact structure 1 is extremely stable in water with only trace levels of silver ions being detected. On the other hand, compounds 2 and 3, in which only the phosphonic acid functional groups were bonded to the inorganic network, released larger quantities of silver ions into aqueous solution. These results which were compared with the silver release of the previously described compound 4 (Ag6(3-PO3-C6H4-COO)2). The results clearly show that the release capacity of silver-based metal organic framework can be tuned by 3 modifying their topology which, in the present study, is governed by the regio-isomer of the organic precursor and the synthetic conditions under which the hybrids are prepared.4

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Section: Resultsmentioning

confidence: 99%

“…Accordingly, the drug, or pro-drug, (e.g. peptide, 19 nicotinic acid 20 ) must possess a reactive functional groupity (e.g. carboxylate) that can interact with the inorganic network that is generated during the formation of the hybrid.…”

Section: Introductionmentioning

confidence: 99%

Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

et al. 2015

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“…Recently, remarkable progress has been made in this regard in the development of metal-organic materials (MOMs), such as metal-organic frameworks (MOFs) 5,6 and metal-organic polyhedra (MOPs) 7 , assembled from molecular building units. These materials possess unique properties and vast application potential [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] . The hallmark of these new materials is their modular design, which is far beyond the scope of other porous materials 22,[25][26][27][28][29][30][31][32][33][34][35][36] and allows for facile structure and property tuning.…”

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confidence: 99%

Porous materials with pre-designed single-molecule traps for CO2 selective adsorption

et al. 2013

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Despite tremendous efforts, precise control in the synthesis of porous materials with pre-designed pore properties for desired applications remains challenging. Newly emerged porous metal-organic materials, such as metal-organic polyhedra and metal-organic frameworks, are amenable to design and property tuning, enabling precise control of functionality by accurate design of structures at the molecular level. Here we propose and validate, both experimentally and computationally, a precisely designed cavity, termed a 'single-molecule trap', with the desired size and properties suitable for trapping target CO 2 molecules. Such a single-molecule trap can strengthen CO 2 -host interactions without evoking chemical bonding, thus showing potential for CO 2 capture. Molecular single-molecule traps in the form of metal-organic polyhedra are designed, synthesised and tested for selective adsorption of CO 2 over N 2 and CH 4 , demonstrating the trapping effect. Building these pre-designed singlemolecule traps into extended frameworks yields metal-organic frameworks with efficient mass transfer, whereas the CO 2 selective adsorption nature of single-molecule traps is preserved.

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“…Sorbents examined for fluorocarbon-based adsorption chillers have thus far been limited to activated carbon 7,8 and zeolites 9 . Although the literature on gas adsorption in MOFs is very extensive [10][11][12][13][14][15][16][17][18][19] , fluorocarbon adsorption has been limited to zeolites and activated carbons [7][8][9] . The adsorption behaviour of the MOFs with high capacity at very low vapor pressures suggests MOFs can, in principle, be used in fluorocarbon-based adsorption heat pumps, separation of fluorocarbons from azeotrope mixture, removal of environmentally hazardous gases from atmosphere.…”

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confidence: 99%

Fluorocarbon adsorption in hierarchical porous frameworks

et al. 2014

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Metal-organic frameworks comprise an important class of solid-state materials and have potential for many emerging applications such as energy storage, separation, catalysis and bio-medical. Here we report the adsorption behaviour of a series of fluorocarbon derivatives on a set of microporous and hierarchical mesoporous frameworks. The microporous frameworks show a saturation uptake capacity for dichlorodifluoromethane of 44 mmol g À 1 at a very low relative saturation pressure (P/P o ) of 0.02. In contrast, the mesoporous framework shows an exceptionally high uptake capacity reaching 414 mmol g À 1 at P/P o of 0.4. Adsorption affinity in terms of mass loading and isosteric heats of adsorption is found to generally correlate with the polarizability and boiling point of the refrigerant, with dichlorodifluoromethane 4chlorodifluoromethane 4chlorotrifluoromethane 4tetrafluoromethane 4methane. These results suggest the possibility of exploiting these sorbents for separation of azeotropic mixtures of fluorocarbons and use in eco-friendly fluorocarbon-based adsorption cooling.

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An Adaptable Peptide-Based Porous Material

Cited by 361 publications

References 32 publications

Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

Silver-Based Hybrid Materials from meta- or para-Phosphonobenzoic Acid: Influence of the Topology on Silver Release in Water

Porous materials with pre-designed single-molecule traps for CO2 selective adsorption

Fluorocarbon adsorption in hierarchical porous frameworks

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