An acute bout of exercise modulate the inflammatory response in peripheral blood mononuclear cells in healthy young men

Ulven, Stine Marie; Foss, Silje Stange; Skjølsvik, Anne Marie; Stadheim, Hans Kristian; Myhrstad, Mari; Raael, Ellen; Sandvik, Marit; Narverud, Ingunn; Andersen, Lene Frost; Jensen, Jørgen; Holven, Kirsten B.

doi:10.3109/13813455.2014.1003566

Cited by 41 publications

(35 citation statements)

References 49 publications

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“…In addition to circulating plasma molecules, we also investigated PBMC gene expression response to exercise both because immune cells play a critical role in muscle damage repair and regeneration and as a system-wide marker of alterations in gene expression (Gjevestad et al, 2015; Philippou et al, 2012; Radom-Aizik et al, 2009; Ulven et al, 2015). Transcripts presented two main trajectories with up- and down-regulated genes reaching a maximum response at 2 min and rapidly returning to baseline within 30-60 min ( Figure 4a , Table S4 ).…”

Section: Resultsmentioning

confidence: 99%

Molecular Choreography of Acute Exercise

Contrepois

Moneghetti

Hornburg

et al. 2020

Preprint

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Exercise testing is routinely used in clinical practice to assess fitness - a strong predictor of survival - as well as causes of exercise limitations. While these studies often focus on cardiopulmonary response and selected molecular pathways, the dynamic system-wide molecular response to exercise has not been fully characterized. We performed a longitudinal multi-omic profiling of plasma and peripheral blood mononuclear cells including transcriptome, immunome, proteome, metabolome and lipidome in 36 well-characterized volunteers before and after a controlled bout of acute exercise (2, 15, 30 min and 1 hour in recovery). Integrative analysis revealed an orchestrated choreography of biological processes across key tissues. Most of these processes were dampened in insulin resistant participants. Finally, we discovered biological pathways involved in exercise capacity and developed prediction models revealing potential resting blood-based biomarkers of fitness.

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Section: Resultsmentioning

confidence: 99%

Molecular Choreography of Acute Exercise

Contrepois

Moneghetti

Hornburg

et al. 2020

Preprint

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“…After 20 minutes of cycling at 50% of VO 2peak , a non-significant decrease was observed in TNF-α (4.5 to 4.2 picogram/milliliter [pg/ml]). With regard to vigorous intensity exercise, the study of Ulven et al 19 reported an increase in serum levels of TNF-α after 60 minutes of cycling at 70% of VO 2Max . These disparities between studies may be explained in part by differences in the exercise protocols adopted.…”

Section: Discussionmentioning

confidence: 99%

Acute Effects of Physical Exercise at different intensities on Inflammatory Markers in Obese Adolescents

et al. 2019

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Obesity promotes a state of chronic low-grade inflammation of white adipose tissue, which is associated with different chronic diseases. While exercise induces an anti-inflammatory environment, little is known about the acute effects of continuous exercise at different intensities on inflammatory markers in obese adolescents. This study included 10 obese adolescents of both sexes, between 15 and 18 years of age. Volunteers performed two 30-minute exercise sessions. The 1st exercise session was performed at moderate intensity (55% VO 2peak) and the 2nd at vigorous intensity (75% VO 2peak), with a one-week interval between sessions. Blood samples were collected 10 minutes before and 20 minutes after the exercise sessions. Inflammatory markers were analyzed using the chemiluminescence method. Statistical analysis was performed using the two-factors ANOVA test for repeated measures and statistical significance was set at 5% (p <0.05). The results showed that 30 minutes of moderate aerobic exercise resulted in significant changes in circulating levels of TNF-α (6.23 ± 1.64 to 7.03 ± 1.49) and IL-6 (3.35 ± 1.53 to 3.85 ± 1.73). The results of this study showed that a single exercise session of moderate intensity lasting for 30 minutes induced acute responses in inflammatory markers in the obese adolescents evaluated.

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“…Messenger RNA expression of genes involved in immune and T cell function (eg, interleukin (IL)-1β and IL-8) are upregulated following acute cycling exercise 37. It is plausible that interval but not continuous exercise induced a change in this gene expression.…”

Section: Discussionmentioning

confidence: 99%

Interval exercise increases angiogenic cell function in postmenopausal women

Harris

Rakobowchuk

Birch

2017

BMJ Open Sport Exerc Med

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IntroductionExercise can help to negate the increased cardiovascular disease risk observed in women after the menopausal transition. This study sought to determine whether interval or continuous exercise has differential effects on endothelial function and circulating angiogenic cell (CAC) number and function in postmenopausal women.MethodsFifteen healthy postmenopausal women completed a 30 min acute moderate-intensity continuous (CON) and interval exercise (MOD-INT) session on a cycle ergometer on separate days. Nine participants completed a further single 30 min acute heavy-intensity interval (HEAVY-INT) exercise session. Brachial artery flow-mediated dilation (FMD) was assessed pre-exercise and 15 min post-exercise session. CAC number and colony-forming capacity in vitro were assessed post exercise and compared with resting levels.ResultsFMD and CAC number did not change post exercise regardless of exercise type (p>0.05). However, the number (mean±SD) of colony-forming units (CFUs) increased from visit 1 (12±10 CFUs/well) to post MOD-INT (32±30 CFUs/well) and post HEAVY-INT (38±23 CFUs/well) but not post CON (13±14 CFUs/well).ConclusionA single session of interval exercise is more effective than a continuous exercise session for increasing the intercellular communication of CACs, regardless of exercise intensity. The enhanced ability of CACs to form colonies may reflect an increased number and/or function of angiogenic T-cells. The repeated exertions to higher work rates during interval exercise may explain this response. Repeated exercise sessions might be required to improve FMD in postmenopausal women.

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An acute bout of exercise modulate the inflammatory response in peripheral blood mononuclear cells in healthy young men

Cited by 41 publications

References 49 publications

Molecular Choreography of Acute Exercise

Molecular Choreography of Acute Exercise

Acute Effects of Physical Exercise at different intensities on Inflammatory Markers in Obese Adolescents

Interval exercise increases angiogenic cell function in postmenopausal women

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