An active peptide purified from gastrointestinal enzyme hydrolysate of Pacific cod skin gelatin attenuates angiotensin-1 converting enzyme (ACE) activity and cellular oxidative stress

Himaya, S.W.A.; Ngo, Dai‐Hung; Ryu, BoMi; Kim, Se‐Kwon

doi:10.1016/j.foodchem.2011.12.020

Cited by 175 publications

(105 citation statements)

References 36 publications

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“…They used stable isotope analysis (AA-CSIA), to evaluate nutrient sources, especially essential amino acids, from Chlorella and Spirulina microalgae, as shown in Table 5. Another interesting approach in microalgae proteins is related to bioactive peptides from microalgae, which can exert hormonal effects in the physiological stages of the human body [80]. Peptides extracted from microalgae have antioxidant, anticoagulant, antihypertensive, immunomodulatory, antimicrobial and cholesterol lowering functions [81].…”

Section: Proteins Amino Acids and Peptidesmentioning

confidence: 99%

Chlorella and Spirulina Microalgae as Sources of Functional Foods, Nutraceuticals, and Food Supplements; an Overview

Andrade

Dias

et al. 2018

MOJFPT

193

115

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Chlorella and Spirulina are the two of the most well-known microalgae genus. Both microalgae genus have a significant content of proteins, vitamins, pigments, fatty acids, sterols, among others, which make their production/application by the food industry quite interesting. Chlorella genus is a eukaryotic microorganism, whereas Spirulina genus (cyanobacteria) is a prokaryotic microorganism. The aim of this review was to provide an overview on Chlorella and Spirulina microalgae, particularly as an alternative source of functional foods, nutraceuticals, and food supplements, in which the following compound groups were addressed: (I) Long-Chain Polyunsaturated Fatty Acids; (II) Phenolic Compounds; (III) Volatile Compounds; (IV) Sterols; (V) Proteins, Amino Acids, Peptides; (VI) Vitamins; (VII) Polysaccharides; (VIII) Pigments and (IX) Food. Chlorella and Spirulina microalgae and their derivatives are concluded not to be widely commercially exploited. However, they are remarkable sources of functional foods, nutraceuticals and food supplements.

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Section: Proteins Amino Acids and Peptidesmentioning

confidence: 99%

Chlorella and Spirulina Microalgae as Sources of Functional Foods, Nutraceuticals, and Food Supplements; an Overview

Andrade

Dias

et al. 2018

MOJFPT

193

115

View full text Add to dashboard Cite

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“…ROS production needs to be regulated or adverse effects like oxidation may damage cell macronutrients such as proteins, lipids, and nucleic acids. Balance in ROS concentration can be achieved by the antioxidant system that exists in the human body and by taking antioxidant supplements [9]. Moreover, ROS has the ability to oxidize nitric oxide (NO) produced from endothelial cells, leading to endothelial dysfunction and the initiation and development of cardiac disease [10].…”

Section: Introductionmentioning

confidence: 99%

Punicalagin Induce the Production of Nitric Oxide and Inhibit Angiotensin Converting Enzyme in Endothelial Cell Line EA.hy926

Omar¹,

Yousr²,

Howell³

2016

ujph

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Introduction: punicalagin, a hydrolysable tannin polyphenol from pomegranate, reported to have a protective effect against many diseases due to its high antioxidant and free radical scavenging activities. Aim, this study investigated the potential antihypertensive activity of punicalagin in human derived EA.hy926 endothelial cell model, via two mechanisms. In first mechanism, punicalagin enhance the nitric oxide production through scavenging reactive oxygen specious (ROS) and activating the endothelial nitric oxide synthase enzyme (eNOS). In second mechanism, punicalagin showed effect activity by inhibiting the angiotensin converting enzyme (ACE). Methods: The effect of different concentrations (1-100 µM) of punicalagin on EA.hy926 cells was measured using MTT assay. Induction of ROS was done using Ang II and scavenging activity of punicalagin was assessed by flow cytometer and fluorimeter. NO production was measured in order to determine the effective dose of punicalagin followed by measuring the ability of punicalagin to induce eNOS activity and the enzyme expression by Western blotting cellular Ca 2+ concentration and ACE inhibition were also determined. Results: Punicalagin (1-60 µM) reduced ROS production in EA.hy926, which induced by added angiotensin II, as shown by flow cytometry and by fluorometry. In addition, at the same concentration the nitric oxide production was increased in a dose-dependent manner due to increased eNOS activation. The activation of eNOS enzyme was promoted by an increase of cellular calcium concentration at the tested concentrations. Examined punicalagin concentrations significantly inhibited ACE activity, possibly due to zinc binding. Conclusion: punicalagin clearly exhibits the potential for reducing hypertensive activity by a dual mechanism of nitric oxide synthase induction by increasing nitric oxide levels, and ACE inhibition.

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“…Radical scavenging Protective effect against oxidation of membrane lipids, proteins and nuclear DNA in mouse monocyte cells [23] The antioxidant effect of some collagen-derived peptides has been observed in culture cells. For example, peptides isolated from cod skin gelatine may protect living cells against free radical mediated oxidative damage [23,26].…”

Section: Trypsinmentioning

confidence: 99%

“…For example, peptides isolated from cod skin gelatine may protect living cells against free radical mediated oxidative damage [23,26]. Two potent antioxidant peptides derived from jumbo squid skin gelatine may exert a protective effect in human lung fibroblasts against radical-mediated oxidation [27].…”

Section: Trypsinmentioning

confidence: 99%

Marine Collagen as a Source of Bioactive Molecules: A Review

Alemán¹,

Martínez-Álvarez

2013

NPJ

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Skins, scales and bones are the major by-products of the fish-processing industry. These by-products are not regarded as ordinary saleable products and are usually discarded causing a heavy environmental impact. However, they are a good source of collagen. This collagen could be extracted and further enzymatically hydrolysed to liberate physiologically active peptides. Specifically, some collagen-derived peptides may exhibit interesting antioxidant activity, potent antihypertensive activity, antimicrobial activity against different strains of bacteria, protective effect on cartilage, or capacity to stimulate bone formation. Collagen hydrolysates from fish disposals may also exhibit other interesting activities (e.g., satiety, calciotropic, or opioid). The bioactive properties of collagen-derived peptides, and also their resistance to protein digestion, make them potential ingredients of health promoting foods.

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An active peptide purified from gastrointestinal enzyme hydrolysate of Pacific cod skin gelatin attenuates angiotensin-1 converting enzyme (ACE) activity and cellular oxidative stress

Cited by 175 publications

References 36 publications

Chlorella and Spirulina Microalgae as Sources of Functional Foods, Nutraceuticals, and Food Supplements; an Overview

Chlorella and Spirulina Microalgae as Sources of Functional Foods, Nutraceuticals, and Food Supplements; an Overview

Punicalagin Induce the Production of Nitric Oxide and Inhibit Angiotensin Converting Enzyme in Endothelial Cell Line EA.hy926

Marine Collagen as a Source of Bioactive Molecules: A Review

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