An active finite viscoelastic model for gastric smooth muscle contraction

Panda, Satish Kumar; Buist, Martin L.

doi:10.1101/2021.01.26.428273

Cited by 3 publications

(3 citation statements)

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“…We did not consider any electrophysiological and electromechanical coupling models for sphincter smooth muscle cells. 37 , 38 With more advanced models, it may be possible to examine the electrical and chemical response of the iris tissue during miosis and mydriasis. Second, each iris (healthy or PACG) may have its patient-specific activation force.…”

Section: Discussionmentioning

confidence: 99%

Changes in Iris Stiffness and Permeability in Primary Angle Closure Glaucoma

Panda

Tan

Tun

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

Changes in Iris Stiffness and Permeability in Primary Angle Closure Glaucoma

Panda

Tan

Tun

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…The isostretching exercise has principles in common with the GPR. In both cases, the same process, that is, viscoelastic stress relaxation, takes place and muscles are maintained in a static elongated position, regardless of the type of stretching [48]. This fact could justify the non-difference between the groups.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Global Postural Re-Education in Chronic Non-Specific Low Back Pain: Systematic Review and Meta-Analysis

González-Medina

Pérez-Cabezas

Ruiz-Molinero

et al. 2021

JCM

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Background: The aim of this systematic review and meta-analysis was to evaluate the global postural re-education (GPR) program’s effectiveness compared to other exercise programs in subjects with persistent chronic low back pain. Methods: A systematic review and meta-analysis were carried out using PRISMA2020. An electronic search of scientific databases was performed from their inception to January 2021. Randomized controlled trials that analyzed pain and patient-reported outcomes were included in this review. Four meta-analyses were performed. The outcomes analyzed were disability due to back pain and pain. The risk of bias and quality of evidence were evaluated. The final search was conducted in March. Results: Seven trials were included, totaling 334 patients. The results showed improvement in pain measured by Visual Analogue Scale (VAS) (Standardised Mean Difference (SMD) = −0.69; 95% Confidence Interval (CI), −1.01 to −0.37; p < 0.0001), Numerical Pain Scale (NRS) (SMD = −0.40; 95% CI, −0.87 to 0.06); p = 0.022), VAS + NRS (SMD = −1.32; 95% CI, −1.87 to −0.77; p < 0.0001) and function (Roland Morris Disability Questionnaire (RMDQ)) (SMD = −0.55; 95% CI, −0.83 to −0.27; p < 0.0001) after GPR treatment. Conclusion: This meta-analysis provides reliable evidence that GPR may be an effective method for treating LBP by decreasing pain and improving function, with strong evidence.

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“…First, we treated the active stress in the sphincter region as a constant. We did not consider any electrophysiological and electromechanical coupling models for sphincter smooth muscle cells [35,36]. With more advanced models, it may be possible to examine the electrical and chemical response of the iris tissue during miosis and mydriasis.…”

Section: Limitationsmentioning

confidence: 99%

Changes in Iris Stiffness and Permeability in Primary Angle Closure Glaucoma

Panda

Tan

Tun

et al. 2021

Preprint

Self Cite

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PurposeTo evaluate the biomechanical properties of the iris by evaluating iris movement during pupil constriction and to compare such properties between healthy and primary angle-closure glaucoma (PACG) subjects.MethodsA total of 140 subjects were recruited for this study. In a dark room, the anterior segments of one eye per subject were scanned using anterior segment optical coherence tomography (AS-OCT, SS-1000 CASIA, Tomey Corporation, Nagoya, Japan) imaging during induced pupil constriction with an external white light source of 1700 lux. Using a custom segmentation code, we automatically isolated the iris segments from the AS-OCT images, which were then discretized and transformed into a three-dimensional point cloud. For each iris, a finite element (FE) mesh was constructed from the point cloud, and an inverse FE simulation was performed to match the clinically observed iris constriction in the AS-OCT images. Through this optimization process, we were able to identify the elastic modulus and permeability of each iris.ResultsFor all 140 subjects (95 healthy and 45 PACG of Indian/Chinese ethnicity, Age: 60.2±8.7 for PACG subjects and 57.7±10.1 for healthy subjects), the simulated deformation pattern of the iris during pupil constriction matched well with OCT images. We found that the iris stiffness was higher in PACG than in healthy controls (24.5±8.4 kPa vs 17.1±6.6 kPa with 40 kPa of active stress specified in the sphincter region; p < 0.001), whereas iris permeability was lower (0.41±0.2 mm2/kPa.s vs 0.55±0.2 mm2/kPa.s; p = 0.142).ConclusionThis study suggests that the biomechanical properties of the iris in PACG are different from those in healthy controls. An improved understanding of the biomechanical behavior of the iris may have implications for the understanding and management of angle-closure glaucoma.

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An active finite viscoelastic model for gastric smooth muscle contraction

Cited by 3 publications

References 27 publications

Changes in Iris Stiffness and Permeability in Primary Angle Closure Glaucoma

Changes in Iris Stiffness and Permeability in Primary Angle Closure Glaucoma

Effectiveness of Global Postural Re-Education in Chronic Non-Specific Low Back Pain: Systematic Review and Meta-Analysis

Changes in Iris Stiffness and Permeability in Primary Angle Closure Glaucoma

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