1980
DOI: 10.1016/s0163-4453(80)91084-1
|View full text |Cite
|
Sign up to set email alerts
|

An accidental laboratory infection with African trypanosomes of a defined stock I. The clinical course of the infection

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
5
0

Year Published

1980
1980
2014
2014

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 14 publications
(5 citation statements)
references
References 11 publications
0
5
0
Order By: Relevance
“…An important breakthrough in our understanding of human sleeping sickness would be to discover the genetic basis of human infectivity. Strain TREU 164, originally isolated from tsetse files in Lugala, Uganda, in 1969, has been shown to be human infective by accidental infection of a laboratory worker (57,108). By using human serum-resistant and -sensitive trypanosome clones derived from this isolate (ETaT clones) (133), a gene was identified which is expressed (at the RNA level) only in serum-resistant clones (26).…”
Section: Biochemical and Molecular Basis Of Human Infectivitymentioning
confidence: 99%
“…An important breakthrough in our understanding of human sleeping sickness would be to discover the genetic basis of human infectivity. Strain TREU 164, originally isolated from tsetse files in Lugala, Uganda, in 1969, has been shown to be human infective by accidental infection of a laboratory worker (57,108). By using human serum-resistant and -sensitive trypanosome clones derived from this isolate (ETaT clones) (133), a gene was identified which is expressed (at the RNA level) only in serum-resistant clones (26).…”
Section: Biochemical and Molecular Basis Of Human Infectivitymentioning
confidence: 99%
“…Another [145][146]1994). All of the accidents occurred in 1993 and 1994, and one involved the principal investigator.…”
Section: General Commentsmentioning
confidence: 99%
“…(a) Summary data. Six laboratory-acquired cases have been reported (76,142,146 (Table 18). The earliest reported case occurred in the 1970s.…”
Section: General Commentsmentioning
confidence: 99%
See 1 more Smart Citation
“…Six accidental, laboratory-acquired cases of T. b. rhodesiense have been reported. 3,4,5 Rather than identifying an animal model of a dangerous human pathogen, a safer option would be to identify a non-human pathogen that mimics HAT. Unlike T. b. rhodesiense, T. b. brucei is unable to infect humans, but mimics the pathogenesis of human-infective T. b. rhodesiense in infected animals.…”
Section: Introductionmentioning
confidence: 99%