An accidental emamectin benzoate poisoning in child: A case report

Abstract

Emamectin Benzoate (EB, also known as MK-0244) is the 4′-deoxy-4′-epi-methyl-amino benzoate salt of avermectin B1 (avermectin family of 16-membered macrocyclic lactones), which is similar structurally to natural fermentation products of Streptomyces avermitilis. 1,2 Streptomyces avermitilis is a naturally occurring soil actinomycete. 3 This EB stimulates high-affinity GABA (Gamma Amino Butyric Acid) receptors and increases membrane chlorideion permeability. 1,2 Used as insecticides and pesticides, it is efficacious against many organisms like armyworm species, diamondback moth (Plutellaxylostella), cabbage looper (Trichoplusiani [Hubner]), beet armyworm (Spodopteraexigua (Hubner), etc.. 2 To the best our knowledge, there has been few available literatures regarding EB poisoning in human, and that too lacks specific recommendations to tackle cases of EB poisoning.Here, we report a case of EB poisoning in child resulting in gastrointestinal distress and confusion, which was managed with vigorous lavage, fluids, and supportive treatments. | CASE PRESENTATIONA six-year-old girl was brought to the Emergency Department (ED) of Kalaiya District Hospital, Bara, Nepal, with complaints of nausea, vomiting, and abdominal pain at 3:30 pm. It was accompanied by her parents who had noted her of being alert and playful after returning from school on the same day. The mother while doing

A rare case of fatal Emamectin poisoning

“…The management of emamectin benzoate poisoning is always supportive and symptomatic because there is no known antidote for it. Drugs like benzodiazepines, barbiturates, and valproic acid which increase GABA activity should be avoided since emamectin has GABA-mimetic activity 7,8 . In our case, the victim was unconscious throughout the treatment period and his lab investigations showed raised levels of urea and creatinine.…”

“…Her symptoms improved, and after three days, she was discharged without any neurological deficits. It was suggested that coconut oil might coat the gastric mucosa to delay the absorption of emamectin and may additionally prevent damage to raw mucosa because of its antiulcer nature 8 . Godhiwala et al reported a case of a 40-year-old farmer who ingested emamectin benzoate 5% SG 500g under the influence of alcohol.…”

Outburst of Food Poisoning among Hostellers of Certificate Level Nursing Students at Janaki Medical College, Dhanusha

“…Aureus, shigella, vibrio etc. [9]. Parasites includes Toxoplasma gondii, Giardia lamblia, Taenia solium, cryptosporidium, Entamoeba histolytica.…”