Resveratrol improves emamectin benzoate-induced pyroptosis and inflammation of Ctenopharyngodon idellus hepatic cells by alleviating oxidative stress/endoplasmic reticulum stress

Bi, Yanju; Li, Xiaojing; Wei, Haidong; Xu, Shiwen

doi:10.1016/j.fsi.2023.109148

Fish & Shellfish Immunology

2023

DOI: 10.1016/j.fsi.2023.109148

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Resveratrol improves emamectin benzoate-induced pyroptosis and inflammation of Ctenopharyngodon idellus hepatic cells by alleviating oxidative stress/endoplasmic reticulum stress

Yanju Bi,

Xiaojing Li,

Haidong Wei

et al.

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2024

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Cited by 11 publications

References 53 publications

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Enhanced Precision Immunotherapy of Colorectal Cancer through Chemo‐Photothermal Nanoparticles via Endoplasmic Reticulum Stress Mediated Apoptotic Pathways

Wang,

Bi,

et al. 2024

Advanced Therapeutics

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Colorectal cancer (CRC) stands out as one of the most prevalent gastrointestinal cancers. Current treatment strategies for CRC are significantly hindered by systemic toxicity and suboptimal therapeutic efficacy. This study aims to overcome these limitations by developing a robust tumor‐targeting chemo‐photothermal strategy, combining Bortezomib (BTZ) as a proteasome inhibitor, IR780 iodide as a near‐infrared dye, and Photothermal Therapy (PTT) agent, with hyaluronic acid (HA) serving as the shell for tumor targeting, denoted as HA/PB@IR780. The investigations reveal the impressive tumor‐targeting affinity of HA/PB@IR780, leading to a synergistic chemo‐photothermal therapeutic effect both in vitro and in vivo. Additionally, this material demonstrates the capability for drug release triggered by low pH conditions. Moreover, HA/PB@IR780 induced the generation of reactive oxygen species (ROS), triggered cells apoptosis via the PERK‐CHOP‐Bcl‐2 pathway, and induced Immunogenic Cell Death (ICD) in CT26 cells. Importantly, HA/PB@IR780 selectively targets tumor sites, mitigating systemic toxic side effects and significantly extending the survival of CT26 tumor‐bearing mice. In conclusion, this designed tumor‐targeting nanocarrier represents a promising and potentially effective platform for the precise treatment of CRC.

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Enhanced Precision Immunotherapy of Colorectal Cancer through Chemo‐Photothermal Nanoparticles via Endoplasmic Reticulum Stress Mediated Apoptotic Pathways

Wang,

Bi,

et al. 2024

Advanced Therapeutics

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Exposure to Trimethyltin Chloride Induces Pyroptosis and Immune Dysfunction in Grass Carp CIK Cells by Activating the NF‐κB Pathway Through Oxidative Stress

Ni,

Hong,

et al. 2024

Environmental Toxicology

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Trimethyltin chloride (TMT) is a highly toxic organotin pollutant frequently found in aquatic environments, posing a significant threat to the ecological system. The kidney plays a vital role in the body's detoxification processes, and TMT present in the environment tends to accumulate in the kidneys. However, it remained unclear whether exposure to different doses of TMT could induce pyroptosis and immune dysfunction in grass carp kidney cells (CIK cells). For this purpose, after assessing the half‐maximal inhibitory concentration (IC50) of TMT on CIK cells, we established a model for exposure of CIK cells at varying concentrations of TMT. CIK cells were treated with various doses of TMT (2.5, 5, 10 μM) for 24 h. Oxidative stress levels were measured using kits and fluorescence methods, whereas the expression of related genes was verified through western blot and quantitative real‐time PCR (qRT‐PCR). The results indicated that TMT exposure led to oxidative stress, with increased levels of ROS, H2O2, MDA, and GSH, and inhibited activities of T‐AOC, SOD, and CAT. It activated the NF‐κB pathway, leading to the upregulation of NF‐κB p65, NF‐κB p50, GSDMD, NLRP3, ASC, and Caspase‐1. Furthermore, TMT exposure also resulted in increased expression of cytokines (IL‐18, IL‐6, IL‐2, IL‐1β, and TNF‐α) and decreased expression of antimicrobial peptides (LEAP2, HEPC, and β‐defensin). In summary, exposure to TMT induces dose‐dependent oxidative stress that activates the NF‐κB pathway, leading to pyroptosis and immune dysfunction in grass carp CIK cells.

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Environment-relevant concentrations of cadmium induces necroptosis and inflammation; baicalein maintains gill homeostasis through suppressing ROS/ER stress signaling in common carps (Cyprinus carpio L.)

Li,

Wu,

Chen

et al. 2024

Environmental Pollution

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Resveratrol improves emamectin benzoate-induced pyroptosis and inflammation of Ctenopharyngodon idellus hepatic cells by alleviating oxidative stress/endoplasmic reticulum stress

Cited by 11 publications

References 53 publications

Enhanced Precision Immunotherapy of Colorectal Cancer through Chemo‐Photothermal Nanoparticles via Endoplasmic Reticulum Stress Mediated Apoptotic Pathways

Enhanced Precision Immunotherapy of Colorectal Cancer through Chemo‐Photothermal Nanoparticles via Endoplasmic Reticulum Stress Mediated Apoptotic Pathways

Exposure to Trimethyltin Chloride Induces Pyroptosis and Immune Dysfunction in Grass Carp CIK Cells by Activating the NF‐κB Pathway Through Oxidative Stress

Environment-relevant concentrations of cadmium induces necroptosis and inflammation; baicalein maintains gill homeostasis through suppressing ROS/ER stress signaling in common carps (Cyprinus carpio L.)

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