Amyloidosis of the Upper Aerodigestive Tract

Abstract

Amyloidosis of the upper aerodigestive tract generally behaves as a benign, localized condition treatable by surgical resection. Regular follow-up with laryngoscopy is indicated for early diagnosis of recurrence, and multiple surgical procedures may be required to control symptoms.

KTP Laser in Laryngeal Amyloidosis: Five Cases with Review of Literature

“…Hoarseness is the most common symptom [4,5,16,18]. All the three patients in our study presented with hoarseness.…”

“…Some authors have suggested work up for assessment of collagen vascular diseases, tuberculosis, multiple myeloma, extramedullary plasmacytoma, rheumatoid factor, anti-nuclear antibody, purified protein derivatives, associated familial syndromes and endocrinopathies [17]. Fine needle aspiration of abdominal fat has been shown to be a simple and effective procedure to rule out systemic amyloidosis [5,18]. Biopsies of the lip, gingiva, abdominal fat, rectum and bone marrow have been suggested [5,12,13,15,17,18].…”

Amiloidose com múltiplos focos em trato aéreo-digestivo superior: relato de caso e revisão de literatura

“…As it happened in our case, in some cases, tracheostomy is necessary in order to secure the airway 1 .…”

“…Amyloidosis of the upper aerodigestive tract is usually localized 1,8 , however tongue involvement 2,9 is an exception and is very much associated with the systemic disease.…”

“…In the case of symptomatic and localized amyloidosis, as it usually happens in cases of laryngeal amyloidosis, the lesion must be removed and the patient must be started on periodic treatment, because local and distant relapses are common 1,14 . More over, one must be in constant look out for systemic lesions.…”