KTP Laser in Laryngeal Amyloidosis: Five Cases with Review of Literature

Dosemane, Deviprasad; Pujary, Kailesh; Balakrishnan, R.; Nayak, Dipak Ranjan

doi:10.1007/s12070-011-0435-z

Cited by 14 publications

(4 citation statements)

References 28 publications

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“…Management strategies range from observation to balloon dilatation, endoscopic excision and laryngectomy 5 26 Whilst laser (carbon dioxide and potassium titanyl phosphate) excision was considered effective in several studies, 27 – 30 there is evidence that cold endoscopic excision for small laryngeal and localised glottic lesions is appropriate 21 . The paediatric case in the current study employed the use of a microdebrider and coblation wands, the first such case in the literature.…”

Section: Discussionmentioning

confidence: 90%

Laryngeal amyloidosis: diagnosis, pathophysiology and management

et al. 2017

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Section: Discussionmentioning

confidence: 90%

Laryngeal amyloidosis: diagnosis, pathophysiology and management

et al. 2017

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“…In view of the presence of fragile capillaries because of amyloid infiltration, resection of the lesion with simultaneous hemostasis, with the laser, for example, may be the most suitable strategy wherever possible and accessible. 19 Keeping in mind the slow and prolonged disease progression, conservative resection with a yearly follow-up extended for up to 10 years is advised. All of our patients were offered surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile of Patients with Head and Neck Amyloidosis: A Single-Institution Retrospective Chart Review

Singh

Haq

Gautam

et al. 2020

Int Arch Otorhinolaryngol

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Introduction Isolated amyloidosis involving the head and neck is a rare entity. The pathophysiology of the localized disease appears to be distinct from that of the systemic counterpart. Systemic progression of the localized disease is unusual, and the prognosis of the localized form is excellent. Objective To describe the demographic and clinicopathological characteristics of patients presenting with localized head and neck subsite amyloidosis. Methods A retrospective chart review of the patients with head and neck amyloidosis identified by the electronic search of the electronic database of the Departments of Pathology and Otorhinolaryngology was performed. The various demographic and clinical data were tabulated. Results In total, seven patients (four females, three males) with localized head and neck amyloidosis (three supraglottic, three lingual and one sinonasal) were identified. Six patients had AL-amyloid deposits, and one patient had AA-amyloid deposits. Supraglottic involvement and that of the base of the tongue were treated surgically using CO2 laser, and these patients were disease-free at the last follow-up. The patient with sinonasal amyloidosis experienced symptom recurrence after six months of the functional endoscopic sinus surgery. All of the patients were screened for systemic amyloidosis with abdominal fat pad biopsy, and were found to be free of systemic spread. Conclusion Isolated head and neck amyloidosis, as opposed to systemic amyloidosis, has an excellent prognosis in terms of survival. Therefore, systemic amyloidosis should be excluded in all cases. The treatment of choice remains surgical excision; however, watchful waiting may be a suitable strategy for mild symptoms or for cases in which the disease was discovered incidentally.

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“…The differential diagnosis includes hyalinized myomatous polyps, malignancy, and granulomatous conditions such as tuberculosis and scleroma of the larynx; the main differentiation must be made with chondrosarcoma, which is the most frequent cause of a calcified mass in the larynx [43]. The signal characteristics of amyloid on magnetic resonance imaging (MRI) resemble those of skeletal muscles.…”

Section: Other Thoracic Findingsmentioning

confidence: 99%

“…The signal characteristics of amyloid on magnetic resonance imaging (MRI) resemble those of skeletal muscles. This feature may be an important differentiating point because muscle is an easy reference frame, and chondrosarcoma does not appear in this manner on MRI [43].…”

Section: Other Thoracic Findingsmentioning

confidence: 99%

Respiratory Tract Amyloidosis. State-of-the-Art Review with a Focus on Pulmonary Involvement

Almeida

Zanetti

Silva

et al. 2015

Lung

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Amyloidosis is a constellation of disease entities characterized by abnormal extracellular deposition and accumulation of protein and protein derivatives, which show apple-green birefringence when stained with Congo red and viewed under polarized light. Amyloid can infiltrate virtually all organ systems and can display multiple and diverse imaging findings. Pathologically, respiratory involvement occurs in 50 % of patients with amyloidosis, and its clinical signs and symptoms vary depending on whether the disease is systemic or localized. The four main patterns of respiratory tract involvement are tracheobronchial, nodular parenchymal, diffuse alveolar septal, and lymphatic. Imaging findings of amyloidosis are nonspecific and vary in each pattern; knowledge about the disease impairment type is thus very important, and amyloidosis should be considered in the differential diagnosis of other very common diseases, such as infectious diseases, neoplasms, and vasculitis. This literature review describes the main clinical and imaging manifestations of amyloidosis, focusing on respiratory tract involvement and differential diagnosis.

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KTP Laser in Laryngeal Amyloidosis: Five Cases with Review of Literature

Abstract: To study the clinical presentation and review the options in the management of laryngeal amyloidosis.

Cited by 14 publications

References 28 publications

Laryngeal amyloidosis: diagnosis, pathophysiology and management

Laryngeal amyloidosis: diagnosis, pathophysiology and management

Clinical Profile of Patients with Head and Neck Amyloidosis: A Single-Institution Retrospective Chart Review

Respiratory Tract Amyloidosis. State-of-the-Art Review with a Focus on Pulmonary Involvement

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