Amyloidosis: An overview

Scott, Penelope P.; Scott, William W.; Siegelman, Stanley S.

doi:10.1016/0037-198x(86)90027-1

Cited by 67 publications

(32 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Facial pain associated with bony erosion is a worrying feature [5]. Meticulous surgery produces substantial symptomatic improvement in these patients [11].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation

Kumar

Pant

Kumar

et al. 2016

Head and Neck Pathol

View full text Add to dashboard Cite

Primary localized amyloidosis in the head and neck region is a rare entity. The most commonly involved organ is larynx. Primary amyloidosis localized to the sinonasal tract is extremely rare. We report one such case along with a brief review of the associated literature. The aim of reporting this case is to emphasize the fact that sometimes nasal amyloidosis can also present with signs and symptoms of nasal and nasopharyngeal malignancy. The definitive diagnosis in such cases depends upon histopathology and further confirmed by immunohistochemistry. A 55-year old male presented with recurrent episodes of nasal bleed, bilateral nasal obstruction, and bilateral hearing loss from last 7 years. On clinical examination a mass was found in the nasal cavity on both sides reaching up to the nasopharynx. Contrast enhanced CT scan revealed that the mass was extending up to the skull base and destroying bony landmarks of the nasal cavity and paranasal sinuses. Mass was proved to be amyloidosis after histopathological examination. It showed multiple blotches of globular submucosal deposit of amyloid, on staining with Congo red. Immunohistochemistry confirmed AL amyloidosis with expression of mixed kappa and lambda light chain immunoglobulin (j [ k). No evidence of systemic amyloidosis was found after proper work up. It was managed by conservative surgery.

show abstract

“…Facial pain associated with bony erosion is a worrying feature [5]. Meticulous surgery produces substantial symptomatic improvement in these patients [11].…”

Section: Discussionmentioning

confidence: 99%

“…Larynx is the most commonly affected site (61 %) followed by oropharynx (23 %), trachea (9 %), and orbit (4 %). Only 3 % of cases occur in the nasopharynx [4,5]. Sinonasal globular amyloidosis is extremely rare.…”

Section: Introductionmentioning

confidence: 99%

Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation

Kumar

Pant

Kumar

et al. 2016

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…Among the sites, larynx is affected most frequently (61%), followed by oropharynx (23%), trachea (9%), and orbit (4%) (Glenner GG, 1980) (Scott PP, 1986). Only 3% of cases occur in the nasopharynx (Glenner GG, 1980) (Scott PP, 1986).…”

Section: Localizationmentioning

confidence: 99%

Localized ENT Amyloidosis – Literature Overview

Hammami¹,

Mnejja²,

Sellami³

et al. 2011

Amyloidosis - An Insight to Disease of Systems and Novel Therapies

View full text Add to dashboard Cite

“…A wide variety of clinical syndromes emerge with occurrence of organ dysfunction that happens as a result of compression and displacement of normal tissue by progressive accumulation of amyloid (2). Amyloidosis is mostly presented in systemic form; however, 10%-20% of presentations are localized (3). Systemic amyloidosis is generally classified in two main forms according to the biochemical structure of the amyloid fibrils; primary amyloidosis (AL-amyloidosis) and secondary amyloidosis (AA-amyloidosis).…”

mentioning

confidence: 99%

“…In the literature, there are very few studies describing the imaging findings of abdominal manifestations of amyloidosis (5-7) and they comprise mostly barium studies and ultrasonography (US) and few computed tomography (CT) examinations (2)(3)(4)(5)(6). In this study we aimed to review abdominal amyloidosis imaging findings as regards CT and magnetic resonance imaging (MRI).…”

mentioning

confidence: 99%