Amyloid neuropathy due to monoclonal gammopathy

Neundörfer, B.; Meyer, Jürgen G.; Volk, Benedikt

doi:10.1007/bf00313622

Cited by 12 publications

(4 citation statements)

References 25 publications

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“…From consideration of these 3 1 patients with neuropathy and primary amyloidosis and review of previously reported cases [4,6,7,16,17,25,26,[31][32][33], a fairly consistent type of peripheral neuropathy and natural history emerges. The typical patient is a man in the late decades of life who has a sensorimotorautonomic neuropathy without systemic involvement or, in approximately half of the cases, with cardiac, hematological, renal, o r gastrointestinal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The natural history of peripheral neuropathy in primary systemic amyloidosis

Kelly

Kyle

O’Brien

et al. 1979

Annals of Neurology

170

110

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The records of 31 patients with primary systemic amyloidosis and peripheral neuropathy seen during a 17-year period were analyzed to define the natural history of the neuropathy. Patients tended to be older men with a painful, distal, symmetrical sensorimotor neuropathy and prominent autonomic features. Loss of pain and temperature sensation was frequently more striking than loss of mechanoreception. Renal, cardiac, hematological, and gastrointestinal dysfunction often overshadowed the neuropathy. Clinical, neurophysiological, and histopathological studies pointed to axonal degeneration with predominant but not exclusive involvement of small myelinated and unmyelinated fibers. The neuropathy was progressive in all patients with or without treatment, but death was typically due to supervening medical complications.

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Section: Discussionmentioning

confidence: 99%

The natural history of peripheral neuropathy in primary systemic amyloidosis

Kelly

Kyle

O’Brien

et al. 1979

Annals of Neurology

170

110

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“…Our five cases had almost normal hematological values at the time of diagnosis. and the ESR elevation was Acta Med Scund 208 12 'I References I , 4,13,17,21,26,28,29,30,32,34,37,38,39,44,46,47,48,49,50,53, 5 5 , 56, 57, 62. 15 cases normal or below 2 %.…”

Section: Hematological Featuresmentioning

confidence: 99%

Osteosclerotic Myeloma with Polyneuropathy

Reitan

Pape

Fosså

et al. 1980

Journal of Internal Medicine

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Five cases of histologically verified plasma cell myeloma in sclerotic skeletal foci and polyneuropathy are reported. Thirty similar cases were collected from the literature. They illustrate a special form of plasma cell neoplasia. The characteristic features are osteosclerosis, polyneuropathy resembling polyradiculitis, approximately normal hemoglobin concentration, bone marrow smears and ESR, low concentration of M-protein, and absence of Bence-Jones' proteinuria. Slow progression of the disease is a possible additional feature. It is hypothesized that autoimmune mechanisms are involved in the pathogenesis. This hypothesis is based on the observation of circulating immune complexes, positive Waaler's reaction and relative increase in the number of circulating B-lymphocytes.

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“…M-component is generally considered harmless in patients without an underlying hematologic malignancy. However, neurological symptoms, mostly polyneuropathy, have been reported in monoclonal gammopathies (Chazot et al 1976, Fraser et al 1976, Kaufman 1976, Neundorfer et al 1977, Trotter et al 1977, Julien et al 1978, Read et al 1978, Haggblom & Von Scheele 1979, Galli et al 1980, Latov et al 1980, Dalakas & Engel 1981, Kelly et al 1981. Neuropathies are found in patients with myeloma or Waldenstrom's macroglobulinemia (Victor et al 1958, Zwashita et al 1974.…”

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confidence: 99%

Monoclonal gammopathy with neurological signs and symptoms

Mähönen

Partanen

Collan

et al. 1982

Acta Neurologica Scandinavica

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Clinical, neurophysiological and muscle biopsy findings in ten patients with monoclonal gammopathy are reported. Three patients had polyneuropathy, one had hemiparkinsonism, one migraine and radicular symptoms and one paresthesiae and radicular symptoms. Amyloidosis was not found in muscle biopsy specimens. All but one patient with neurological findings also had positive immunofluorescence staining for tissue-bound immunoglobulins in muscle biopsy specimens. The tissue-bound immunoglobulins usually belonged to the same class as the M-component. None of the biopsies of patients without neurological findings were positive.

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Amyloid neuropathy due to monoclonal gammopathy

Cited by 12 publications

References 25 publications

The natural history of peripheral neuropathy in primary systemic amyloidosis

The natural history of peripheral neuropathy in primary systemic amyloidosis

Osteosclerotic Myeloma with Polyneuropathy

Monoclonal gammopathy with neurological signs and symptoms

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