Amyloid heart disease: pathomorphology, diagnostic approaches and treatment options

Rameeva, A.S.; Рамеев, В.В.; Моисеев, С.В.; Pan, Tianyue; Kozlovskaya, L V

doi:10.26442/20751753.2018.12.000020

Cited by 3 publications

(2 citation statements)

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“…С целью назначения патогенетической терапии необходимо не просто выявление амилоидоза, но и его типирование, посколь- Рисунок 6. Технология спекл трекинг эхокардиографии (СТЭ) представлена в виде «бычьего глаза» КЛИНИЧЕСКИЙ СЛУЧАЙ § ку специфическая терапия, начатая в ранние сроки заболевания, позволяет уменьшить степень поражения органов-мишеней [1,3]. Наличие поражения нервной системы, сердца и почек требует мультидисциплинарного подхода к лечению этой категории пациентов.…”

Section: заключениеunclassified

“…Однако по неизвестным причинам заболевание у мужчин манифестирует в более молодом возрасте, чем у женщин. Также у мужчин чаще, чем у женщин, встречается ATTR-амилоидоз сердца [1][2][3]. Время дебюта клинической симптоматики варьируется в широких пределах от 20 лет и выше, например, средний возраст появления транстиретинового амилоидоза Val30Met в Японии и Португалии составляет 32 года, а в Швеции 56 лет.…”

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Experience with tafamidis in a patient with transthyretin amyloidosis

et al. 2020

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Transthyretin amyloidosis (ATTR) is a threatening and severe genetic disease characterized by damages to organs and systems caused by a pathological protein transthyretin produced in the liver. Clinical manifestations of this disease vary from injuries of the nervous system to injuries of the cardiovascular system. Prognosis for ATTR-amyloidosis remains unfavorable. The absence of pathognomonic symptoms complicates diagnostics of this disease, which tends to simulate other conditions. At present, medicines exist, which are pathogenetic in the treatment of ATTR-amyloidosis. The article describes a clinical case of ATTR-amyloidosis with primary heart injury complicated with functional class III chronic heart failure during the tafamidis treatment.

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Experience with tafamidis in a patient with transthyretin amyloidosis

et al. 2020

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Amyloid cardiomyopathy in the elderly: clinical options, difficulties in diagnosis and treatment

Эттингер

Александровна²,

Gendlin

et al. 2020

Medical Journal of the Russian Federation

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This article analyzes the frequency and features of cardiac amyloidosis in the elderly. The morphology and pathogenesis of amyloid cardiomyopathy are presented. The features of the clinical picture of the heart and aortic lesions in systemic and local variants of amyloidosis are analyzed. Polymorbidity in older people, which complicates the diagnosis of cardiac amyloidosis and leads to a delay in treatment, is reviewed. The diagnostic methods of various types of cardiac amyloidosis are evaluated. Modern trends in the treatment of amyloidosis are presented.

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Cardiac amyloidosis, features of diagnosis and treatment

Demyanenko,

Varavin,

Santakov

2024

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Cardiac amyloidosis is considered a rare disease, but as diagnostic capabilities increase, so does the assessment of its prevalence. Cardiac amyloidosis manifests itself with symptoms of restrictive cardiomyopathy, leading to progressive heart failure. However, the underlying pathogenetic mechanisms of the disease differ. This literature review provides an overview of cardiac amyloidosis, from classification to molecular mechanisms and modern treatment options.

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Amyloid heart disease: pathomorphology, diagnostic approaches and treatment options

Cited by 3 publications

References 0 publications

Experience with tafamidis in a patient with transthyretin amyloidosis

Experience with tafamidis in a patient with transthyretin amyloidosis

Amyloid cardiomyopathy in the elderly: clinical options, difficulties in diagnosis and treatment

Cardiac amyloidosis, features of diagnosis and treatment

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