2015
DOI: 10.1159/000438702
|View full text |Cite
|
Sign up to set email alerts
|

Amyloid Beta Peptide 1-42 Induces SH-SY5Y Cell Apoptosis via the Promotion of Meg3 Long Noncoding RNA Expression

Abstract: Background/Aim: The mechanisms and processes of amyloid beta (Aβ)1-42/Aβ1-40 degeneration and deposition of neuron damage are still not clear. The long noncoding RNA (lncRNA) is one of the members of the noncoding RNA family. In this study, we aimed to investigate whether Aβ1-42 inhibited SH-SY5Y cells in vitro through modulating Meg3 lncRNA. Methods: The Alzheimer's disease (AD) senile plaque cell model was generated using synthetic Aβ1-42-treated SH-SY5Y cells. MTT… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
6
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(6 citation statements)
references
References 12 publications
0
6
0
Order By: Relevance
“…A cellular model of AD was established, in which treatment of AB1‐42 induced significant in vitro injuries in SH‐SY5Y cells 16–19 . In the current study, we examined the response of LINC01311 expression in AB1‐42‐treated SH‐SY5Y cells,…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…A cellular model of AD was established, in which treatment of AB1‐42 induced significant in vitro injuries in SH‐SY5Y cells 16–19 . In the current study, we examined the response of LINC01311 expression in AB1‐42‐treated SH‐SY5Y cells,…”
Section: Resultsmentioning
confidence: 99%
“…A cellular model of AD was established, in which treatment of AB1-42 induced significant in vitro injuries in SH-SY5Y cells. [16][17][18][19] In the current study, we examined the response of LINC01311 expression in AB1-42-treated SH-SY5Y cells, In one scheme, SH-SY5Y cells were treated with 20 μM AB1-42 for 0-72 hr. It showed that, once treatment time was above 2 hr, LINC01311 was significantly reduced in a time-dependent trend in SH-SY5Y cells (Figure 1a, *p < .05).…”
Section: Linc01311 Was Downregulated In Ab1-42 Treated Sh-sy5y Cellsmentioning
confidence: 99%
See 1 more Smart Citation
“…Sorcin is not able to cross the cell membrane, and therefore, it cannot activate endogenous PMCA in SH-SY5Y membranes. However, it has been shown that exogenous Aβ can be internalized in HEK-293 cells overexpressing APP [ 61 , 62 ], in neurons from cultured hippocampal slices [ 63 , 64 ], in mouse neuroblastoma (N2A) cells [ 33 ], and in human SH-SY5H cells [ 65 ], as reviewed in [ 34 ]. Extracellular tau has also been reported to be internalized by neurons in culture [ 35 , 36 , 37 , 38 , 66 ].…”
Section: Discussionmentioning
confidence: 99%
“…Extracellular tau has also been reported to be internalized by neurons in culture [ 35 , 36 , 37 , 38 , 66 ]. Through their internalization, Aβ and tau promote toxic effects [ 65 , 66 ]. Therefore, the inhibition of endogenous PMCA observed in membranes treated with exogenous Aβ or tau indicates that both of them cross the plasma membrane and inhibit PMCA.…”
Section: Discussionmentioning
confidence: 99%