Amyloid- and FDG-PET in sporadic Creutzfeldt-Jakob disease: Correlation with pathological prion protein in neuropathology

Matías‐Guiu, Jordi A.; Guerrero-Márquez, Carmen; Cabrera‐Martín, María Nieves; Gómez‐Pinedo, Ulises; Romeral, María; Mayo, Diego Cameno; Porta‐Etessam, Jesús; Moreno‐Ramos, Teresa; Carreras, José

doi:10.1080/19336896.2017.1314427

Cited by 16 publications

(8 citation statements)

References 29 publications

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“…Broadly, 18 F-FDG-PET was suggested to be of diagnostic relevance in the differential diagnosis of sCJD from other forms of rapidly progressive dementia in a few cases and series. The parietooccipital cortex was mainly affected with hypometabolism in patients with visual symptoms which is in line with our findings [19,20]. However, the diagnostic relevance of 18 F-FDG-PET imaging in differential diagnosis of Heidenhain-variant sCJD remains elusive due to a lack of prospective trials but can be considered in unclear cases of rapidly progressive dementia.…”

Section: Discussionsupporting

confidence: 88%

An enigmatic case of cortical anopsia: Antemortem diagnosis of a 14-3-3 negative Heidenhain-variant MM1-sCJD

Obergassel

Meuth

Wiendl

et al. 2019

Prion

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Sporadic Creutzfeldt-Jakob disease is the predominant type of human prion disease. While routine diagnostic in phenotypic cases has advanced considerably, the clinical heterogeneity and rarity of subtypes continue to constitute a major clinical and diagnostic challenge. Here, we report a peculiar case of the Heidenhain-variant of MM1 sporadic Creutzfeldt-Jakob disease presenting as a stroke mimic in an 81-year-old patient with a rapid and clinically distinct course of disease as compared to previously reported cases. While 14-3-3 protein was negative, clinical findings substantiated by 18 F-FDG-PET imaging and RT-QuIC-Assay were able to establish the diagnosis. We conclude that in cases presenting with rapid progressive dementia secondary to sudden cortical anopsia the Heidenhain-variant of CJD should be considered.

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Section: Discussionsupporting

confidence: 88%

An enigmatic case of cortical anopsia: Antemortem diagnosis of a 14-3-3 negative Heidenhain-variant MM1-sCJD

Obergassel

Meuth

Wiendl

et al. 2019

Prion

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“…Considering to brain metabolism, however, a recent study indicated the [ 18 F]-AV-1451 PET was not suitable for patients with RPD due to sCJD, due to different pathological process [8]. As for the technique of FDG-PET, it has an established role in the diagnostic workup of patients with sCJD [9,10]. We have summarized a table showing the changes in FDG-PET in sCJD patients reported from literature (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Combined findings of FDG-PET and arterial spin labeling in sporadic Creutzfeldt-Jakob disease

Yuan

Wang

2018

Prion

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Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal progressive neurodegenerative disease. Multimodal approaches, including electroencephalogram, diffusion-weighted imaging (DWI) of brain MRI, and cerebrospinal fluid biomarkers, have been applied to increase the diagnostic accuracy of sCJD. Although previous studies suggested DWI could be the most useful modality for sCJD diagnosis, whether metabolism changes underlying in sCJD are still poorly understood. To the best of our knowledge, there are only one case using the technique of arterial spin labeling (ASL) to detection and follow-up of perfusion changes in CJD. Herein, we described a 71-year-old woman presented with progressive cognitive decline, behavioral and psychological symptoms for two months. The patient died one month later after her admission. As far as we know, this is the first report using the combination of fluorodeoxyglucose positron emission tomography and ASL to explore the metabolism changes in sCJD. Our case exemplifies the difficulty clinicians may face in the diagnosis of sCJD.

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“…More generally, the imaging of prion diseases was well reviewed by Macfarlane et al , in 2007. [ 2 ] There are also more recent reports of imaging with other PET tracers such as translocator protein (TSPO) ligands, dueterodeprenyl PET for microglial activation, florbetaben for amyloid deposition and oxygen-15 water for blood flow,[ 20 21 22 23 ] and a report correlating FDG PET with cerebral blood flow measured by MR arterial spin labeling. [ 24 ]…”

Section: Discussionmentioning

confidence: 99%

“…More generally, the imaging of prion diseases was well reviewed by Macfarlane et al, in 2007. [2] There are also more recent reports of imaging with other PET tracers such as translocator protein (TSPO) ligands, dueterodeprenyl PET for microglial activation, florbetaben for amyloid deposition and oxygen-15 water for blood flow, [20][21][22][23] and a report correlating FDG PET with cerebral blood flow measured by MR arterial spin labeling. [24] As in this case, multimodal neuroimaging can form an important part of the investigation of suspected prion disease, by detecting the combination of cortical diffusion-restriction and hypometabolism.…”

Section: Discussionmentioning

confidence: 99%

18FDG PET-CT in sporadic Creutzfeldt-Jakob disease, correlated with MRI and histology

et al. 2021

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We present a case of sporadic Creutzfeldt–Jakob disease with profoundly abnormal 18fluoro-deoxy-glucose positron emission tomography with computed tomography (FDG PET-CT) at an early stage, and correlate this with the clear findings at magnetic resonance imaging and also postmortem histology. Prion diseases are rare but important causes of cognitive impairment. The role of FDG PET-CT is discussed, along with other investigations such as electroencephalography and cerebro-spinal fluid analyses.

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Amyloid- and FDG-PET in sporadic Creutzfeldt-Jakob disease: Correlation with pathological prion protein in neuropathology

Cited by 16 publications

References 29 publications

An enigmatic case of cortical anopsia: Antemortem diagnosis of a 14-3-3 negative Heidenhain-variant MM1-sCJD

An enigmatic case of cortical anopsia: Antemortem diagnosis of a 14-3-3 negative Heidenhain-variant MM1-sCJD

Combined findings of FDG-PET and arterial spin labeling in sporadic Creutzfeldt-Jakob disease

18FDG PET-CT in sporadic Creutzfeldt-Jakob disease, correlated with MRI and histology

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