Amygdala volume and social anxiety symptom severity: Does segmentation technique matter?

Jayakar, Reema; Tone, Erin B.; Crosson, Bruce; Turner, Jessica A.; Anderson, Page L.; Phan, K. Luan; Klumpp, Heide

doi:10.1016/j.pscychresns.2019.111006

Cited by 13 publications

(8 citation statements)

References 82 publications

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“…2 The “recon-all” processing stream with default parameters was used for subcortical volume analysis. Details of the segmentation methods and procedures are described in prior publications ( Fischl et al, 2002 ; Jayakar et al, 2020 ). Briefly, the T1-weighted image was segmented into gray matter, white matter, and cerebrospinal fluid.…”

Section: Methodsmentioning

confidence: 99%

Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele

Liao

Cui

Jin

et al. 2021

Front. Aging Neurosci.

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The amygdala is known to be related to cognitive function. In this study, we used an automated approach to segment the amygdala into nine nuclei and evaluated amygdala and nuclei volumetric changes across the adult lifespan in subjects carrying the apolipoprotein E (ApoE) ε3/ε3 allele, and we related those changes to memory function alteration. We found that except the left medial nucleus (Me), whose volume decreased in the old group compared with the middle-early group, all other nuclei volumes presented a significant decline in the old group compared with the young group. Left accessory basal nucleus (AB) and left cortico-amygdaloid transition area (CAT) volumes were also diminished in the middle-late group. In addition, immediate memory recall is impaired by the process of aging, whereas delayed recall and delayed recognition memory functions were not significantly changed. We found significant positive correlations between immediate recall scores and volumes of the bilateral basal nucleus (Ba), AB, anterior amygdaloid area (AAA), CAT, whole amygdala, left lateral nucleus (La), left paralaminar nucleus (PL), and right cortical nucleus (Co). The results suggest that immediate recall memory decline might be associated with volumetric reduction of the amygdala and its nuclei, and the left AB and left CAT might be considered as potential imaging biomarkers of memory decline in aging.

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Section: Methodsmentioning

confidence: 99%

Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele

Liao

Cui

Jin

et al. 2021

Front. Aging Neurosci.

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“…Fifth, some studies indicate that automated segmentation protocols from various software packages result in a systematic overestimation of amygdala volume compared to manual segmentation (Jayakar et al, 2020;Morey et al, 2009;Schoemaker et al, 2016).…”

Section: Residuals Of the Neo-pi-r Depression Scorementioning

confidence: 99%

Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

Schlüter

Fraenz

Friedrich³

et al. 2022

Human Brain Mapping

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Neuroticism is known to have significant health implications. While previous research revealed that interindividual differences in the amygdala function are associated with interindividual differences in neuroticism, the impact of the amygdala's structure and especially microstructure on variations in neuroticism remains unclear. Here, we present the first study using NODDI to examine the association between the in vivo microstructural architecture of the amygdala and neuroticism at the level of neurites.We, therefore, acquired brain images from 221 healthy participants using advanced multi-shell diffusion-weighted imaging. Because the amygdala comprises several nuclei, we, moreover, used a high-resolution T1 image to automatically segment the amygdala into eight different nuclei. Neuroticism and its facets have been assessed using the NEO-PI-R. Finally, we associated neuroticism and its facets with the volume and microstructure of the amygdala nuclei. Statistical analysis revealed that lower neurite density in the lateral amygdala nucleus (La) was significantly associated with higher scores in depression, one of the six neuroticism facets. The La is the sensory relay of the amygdala, filtering incoming information based on previous experiences. Reduced neurite density and related changes in the dendritic structure of the La could impair its filtering function. This again might cause harmless sensory information to be misevaluated as threatening and lead to the altered amygdala responsivity as reported in previous studies investigating the functional correlates of neuroticism and neuroticism-related disorders like depression.

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“…TBI not only causes major mechanical injury of cerebral tissues but also induces secondary mood changes, including anxiety, that persist for years post-injury and severely impair the quality of life for patients ( 3 , 4 ). The amygdala is prominently involved in neurobiological models of anxiety ( 5 , 6 ). To date, several pathological processes responsible for neuronal death, such as excitotoxicity, oxidative stress, inflammation and apoptosis, have been revealed to be involved in the secondary damage (cell death, excitotoxicity, oxidative stress and inflammation) of TBI ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway

Xie

Fan

et al. 2022

Exp Ther Med

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Melatonin is a hormone produced by the pineal gland. Given its capabilities of neuroprotection and low neurotoxicity, melatonin could be a therapeutic strategy for traumatic brain injury (TBI). The present study was conducted to determine the neuroprotective effects of melatonin on TBI-induced anxiety and the possible molecular mechanism. Rats were randomly divided into seven groups. The rodent model of TBI was established using the weight-drop method. Melatonin was administered by intraperitoneal injection at a dose of 10 mg/kg after TBI. H89 (0.02 mg/kg), a special protein kinase A (PKA) inhibitor, or dibutyryl-cyclic adenosine monophosphate (cAMP; 0.1 mg/kg), an activator of PKA, were administered by stereotactic injection of the brain to evaluate the roles of PKA and cAMP-response element-binding protein (CREB) in melatonin-related mood regulation, respectively. At 30 days post-TBI, the changes in anxiety-like behaviors in rats were measured using the open field and elevated plus maze tests. At 24 h post-TBI, the number of activated astrocytes and neuronal apoptosis were evaluated using immunofluorescence assay. The expression levels of inflammatory cytokines (TNF-α and IL-6) in the amygdala were measured using an enzyme-linked immunosorbent assay. The expression levels of PKA, phosphorylated (p)-PKA, CREB, p-CREB, NF-κB and p-NF-κB in the amygdala were detected using western blotting. It was revealed that melatonin partially reversed TBI-induced anxiety-like behavior in rats, and decreased the number of activated astrocytes and neuronal apoptosis in the amygdala induced by TBI. H89 partially blocked the neuroprotective effects of melatonin; while dibutyryl-cAMP not only reduced the H89-induced emotional disturbance but also enhanced the protective effects of melatonin against TBI. Overall, melatonin can alleviate TBI-induced anxiety-like behaviors in rats. Moreover, the underlying mechanism may be associated with the activation of the PKA/CREB signaling pathway.

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Amygdala volume and social anxiety symptom severity: Does segmentation technique matter?

Cited by 13 publications

References 82 publications

Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele

Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele

Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway

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