Amygdala substructure volumes in Major Depressive Disorder

Roddy, Darren; Kelly, John R.; Farrell, Chloë; Doolin, Kelly; Román, Elena; Nasa, Anurag; Frodl, Thomas; Harkin, Andrew; O’Mara, Shane M.; O’Hanlon, Erik; O’Keane, Veronica

doi:10.1016/j.nicl.2021.102781

Cited by 32 publications

(23 citation statements)

References 116 publications

(139 reference statements)

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“…It is established that the limbic system and specifically the amygdala (104,105) are important transdiagnostic nodes in the therapeutic modulation of negative-positive valence systems. Hyper-reactivity of the amygdala is associated with negative processing/affectivity and an attentional bias to negative valenced information, which can occur across a range of stress related disorders, such as depression and various anxiety disorders (106)(107)(108)(109).…”

Section: Lossmentioning

confidence: 99%

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

et al. 2021

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Accumulating clinical evidence shows that psychedelic therapy, by synergistically combining psychopharmacology and psychological support, offers a promising transdiagnostic treatment strategy for a range of disorders with restricted and/or maladaptive habitual patterns of emotion, cognition and behavior, notably, depression (MDD), treatment resistant depression (TRD) and addiction disorders, but perhaps also anxiety disorders, obsessive-compulsive disorder (OCD), Post-Traumatic Stress Disorder (PTSD) and eating disorders. Despite the emergent transdiagnostic evidence, the specific clinical dimensions that psychedelics are efficacious for, and associated underlying neurobiological pathways, remain to be well-characterized. To this end, this review focuses on pre-clinical and clinical evidence of the acute and sustained therapeutic potential of psychedelic therapy in the context of a transdiagnostic dimensional systems framework. Focusing on the Research Domain Criteria (RDoC) as a template, we will describe the multimodal mechanisms underlying the transdiagnostic therapeutic effects of psychedelic therapy, traversing molecular, cellular and network levels. These levels will be mapped to the RDoC constructs of negative and positive valence systems, arousal regulation, social processing, cognitive and sensorimotor systems. In summarizing this literature and framing it transdiagnostically, we hope we can assist the field in moving toward a mechanistic understanding of how psychedelics work for patients and eventually toward a precise-personalized psychedelic therapy paradigm.

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Section: Lossmentioning

confidence: 99%

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

et al. 2021

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“…Their results indicate that volumetric decline was associated with the severity of major depression. Roddy et al (2021) also demonstrated volumetric differences between patients with major depression disorder and healthy controls. They reported differences in the volume of individual nuclei (e.g., right medial nucleus) as well as differences in left-right volume ratio.…”

Section: Residuals Of the Neo-pi-r Depression Scorementioning

confidence: 81%

Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

Schlüter

Fraenz

Friedrich³

et al. 2022

Human Brain Mapping

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Neuroticism is known to have significant health implications. While previous research revealed that interindividual differences in the amygdala function are associated with interindividual differences in neuroticism, the impact of the amygdala's structure and especially microstructure on variations in neuroticism remains unclear. Here, we present the first study using NODDI to examine the association between the in vivo microstructural architecture of the amygdala and neuroticism at the level of neurites.We, therefore, acquired brain images from 221 healthy participants using advanced multi-shell diffusion-weighted imaging. Because the amygdala comprises several nuclei, we, moreover, used a high-resolution T1 image to automatically segment the amygdala into eight different nuclei. Neuroticism and its facets have been assessed using the NEO-PI-R. Finally, we associated neuroticism and its facets with the volume and microstructure of the amygdala nuclei. Statistical analysis revealed that lower neurite density in the lateral amygdala nucleus (La) was significantly associated with higher scores in depression, one of the six neuroticism facets. The La is the sensory relay of the amygdala, filtering incoming information based on previous experiences. Reduced neurite density and related changes in the dendritic structure of the La could impair its filtering function. This again might cause harmless sensory information to be misevaluated as threatening and lead to the altered amygdala responsivity as reported in previous studies investigating the functional correlates of neuroticism and neuroticism-related disorders like depression.

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“…Por otra parte, en la investigación volúmenes de la subestructura de la amígdala, en el trastorno depresivo mayor, Roddy et al (2021) indican que el papel de la amígdala en la experiencia de los estados emocionales y el estrés está bien establecido. Las conexiones de la amígdala al hipotálamo activan el eje hipotalámico-pituitario-suprarrenal (HPA) y la respuesta del cortisol.…”

Section: Hipercortisolemia Sostenida Estrés Y Estructuras Cerebralesunclassified

Hipercortisolemia y estrés. Impacto en las funciones cognitivas

Soto¹

2022

RCUI

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El presente artículo tiene como propósito dar a conocer los hallazgos de una revisión documental sistemática de estudios publicados entre los años 2013 y 2021. El objetivo de la investigación fue establecer la relación de los efectos y alteraciones que produce el cortisol alto y sostenido en el tiempo sobre las funciones cognitivas. Para lograr este objetivo se revisaron 73 documentos, los cuales fueron sometidos a un análisis formal y de contenido, en una secuencia ordenada, orientada por los objetivos de la investigación, seleccionando 36 investigaciones neurocientíficas. Los documentos encontrados corresponden a fuentes primarias y secundarias, asociadas a las temáticas, cortisol en términos de definición, función y alteración; hipercortisolemia sostenida, estrés y estructuras cerebrales; identificación de los daños y alteraciones en las estructuras cerebrales, como la amígdala, el hipocampo y corteza prefrontal, así como funciones cognitivas tales como: atención, memoria, cognición social y planificación, consideradas como prerrequisitos para el desarrollo del aprendizaje. El estudio permitió concluir que los niveles altos de cortisol, por periodos prolongados a causa del estrés físico y psicológico, generan un impacto negativo en el organismo, produciendo una condición neurotóxica para las estructuras cerebrales, modificando su volumen y favoreciendo una disfunción neuronal, generando como consecuencia alteración en las funciones cognitivas, tales como: fallo en el sistema arousal, estado de alerta, concentración, así como memoria episódica y espacial, que en su conjunto afectan el procesamiento de información y aprendizaje.

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Amygdala substructure volumes in Major Depressive Disorder

Cited by 32 publications

References 116 publications

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

Hipercortisolemia y estrés. Impacto en las funciones cognitivas

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