Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions

Ip, Chi Kin; Zhang, Lei; Farzi, Aitak; Qi, Yue; Clarke, Ireni; Reed, Felicia; Shi, Yan‐Chuan; Enriquez, Ronaldo F.; Dayas, Christopher V.; Graham, Brett A.; Begg, Denovan P.; Brüning, Jens C.; Lee, Nicola J.; Hernandez-Sanchez, Diana; Gopalasingam, Gopana; Koller, Júlia; Tasan, Ramon; Sperk, Günther; Herzog, Herbert

doi:10.1016/j.cmet.2019.04.001

Cited by 90 publications

(118 citation statements)

References 60 publications

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“…Nevertheless, caution should be taken when interpreting the normalized values, as changes in amygdala T2W SI values clearly caused a bias. Indeed, the amygdala itself has not only emerged as a brain feeding center with molecularly defined neuronal populations that increase (50)(51)(52) and decrease food intake (53), but it is also a site of high-fat diet-induced inflammation (54,55). Furthermore, amygdala inflammation is a cause of insulin resistance (55), which may explain the strong relationships we found between plasma insulin with T2W SI values in this brain region.…”

Section: Figure 4 Relationships Between Bmi Body Fat Mass Circulatmentioning

confidence: 79%

Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients

Hankir¹,

Rullmann²,

Seyfried³

et al. 2019

JCI Insight

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Section: Figure 4 Relationships Between Bmi Body Fat Mass Circulatmentioning

confidence: 79%

Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients

Hankir¹,

Rullmann²,

Seyfried³

et al. 2019

JCI Insight

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“…In contrast, Y1R antagonists only played a significant role in chow-fed rats ( 115 ). Thirdly, selective activation of CeA NPY neurons leads to increased food intake and reduced energy expenditure ( 116 ). Importantly, selective lack of NPY in CeA neurons attenuates the obesity phenotype, whereas excessive production of NPY in CeA further enhances that phenotype ( 116 ).…”

Section: Npy Indirectly Regulates the Immune Responsementioning

confidence: 99%

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect

Chen

Liu

et al. 2020

Front. Immunol.

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Neuropeptide Y (NPY), which is widely distributed in the nervous system, is involved in regulating a variety of biological processes, including food intake, energy metabolism, and emotional expression. However, emerging evidence points to NPY also as a critical transmitter between the nervous system and immune system, as well as a mediator produced and released by immune cells. In vivo and in vitro studies based on gene-editing techniques and specific NPY receptor agonists and antagonists have demonstrated that NPY is responsible for multifarious direct modulations on immune cells by acting on NPY receptors. Moreover, via the central or peripheral nervous system, NPY is closely connected to body temperature regulation, obesity development, glucose metabolism, and emotional expression, which are all immunomodulatory factors for the immune system. In this review, we focus on the direct role of NPY in immune cells and particularly discuss its indirect impact on the immune response.

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“…In the BLA, somatostatin interneurons express NPY2-receptors, some of which coexpress NPY; stimulating BLA NPY2-receptors reduces tonic GABA release onto local principal neurons [30]. A combination of stress and high-fat diet activates central amygdala NPY neurons, resulting in increased feeding and reduced energy expenditure [67].…”

Section: Cholecystokininmentioning

confidence: 99%

“…In patients with schizophrenia and bipolar disorder, somatostatin positive neurons decreased in the amygdala [42]. Selective activation of NPY neurons in the central amygdala (CeA) leads to increased food intake and decreased energy expenditure under stress [67]. GABAergic serotonin receptor 2a-expressing neurons in the CeA modulate food consumption [108].…”

Section: The Crosstalk Between the Gabaergic System And Thementioning

confidence: 99%

“…In the periphery, NPY is mainly released from the sympathetic nerves and serves as a regulator of fat growth [ 63 ]. In the brain, it is produced in various regions (such as the hypothalamus and amygdala) and is implicated in multiple functions, including energy homeostasis, food intake, metabolism, and stress response [ 64 – 67 ]. Stress can increase NPY expression in the brain [ 67 ].…”

Section: Gabaergic Neuron Signaling and Stressmentioning

confidence: 99%

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GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway

et al. 2020

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Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures. GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system. Accumulating evidence demonstrates that the gut-brain axis, which is primarily regulated by the vagus nerve, is involved in stress, suggesting a communication between the “gut-vagus-brain” pathway and the GABAergic neuronal system. Here, we first summarize the evidence that the GABAergic system plays an essential role in stress responses. In addition, we review the effects of stress on different brain regions and GABAergic neuron subpopulations, including somatostatin, parvalbumin, ionotropic serotonin receptor 5-HT3a, cholecystokinin, neuropeptide Y, and vasoactive intestinal peptide, with regard to signaling events, behavioral changes, and pathobiology of neuropsychiatric diseases. Finally, we discuss the gut-brain bidirectional communications and the connection of the GABAergic system and the gut-vagus-brain pathway.

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Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions

Cited by 90 publications

References 60 publications

Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients

Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect

GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway

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