Amygdala electrical-finger-print (AmygEFP) NeuroFeedback guided by individually-tailored Trauma script for post-traumatic stress disorder: Proof-of-concept

Fruchtman-Steinbok, Tom; Keynan, Jackob Nimrod; Cohen, Avihay; Jaljuli, Iman; Mermelstein, Shiri; Drori, G.; Routledge, Efrat; Krasnoshtein, Michael; Playle, Rebecca; Linden, David; Hendler, Talma

doi:10.1016/j.nicl.2021.102859

Cited by 25 publications

(44 citation statements)

References 48 publications

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“…Patients were able to improve regulation of the Amyg-EFP across 10 sessions. This finding aligns with previous research, showing that subjects can learn to modulate the Amyg-EFP with NF (Fruchtman-Steinbok et al, 2021; Goldway et al, 2018; Keynan et al, 2016, 2019). Since this study lacks an active control group, no conclusion can be drawn regarding specific treatment effects on the improved ability to regulate the Amyg-EFP-signal.…”

Section: Discussionsupporting

confidence: 92%

“…The Amyg-EFP can be used as a proxy for deep brain activation, thereby allowing for amygdala-NF training outside of an MR machine. Previously, Amyg-EFP NF was found to be effective in ameliorating symptoms of post-traumatic stress (Fruchtman-Steinbok et al, 2021; Keynan et al, 2019). The present work had two main goals: (1) To assess whether the Amyg-EFP can be used to probe deep-brain activation in BPD, and (2) to investigate the feasibility of Amyg-EFP NF training with patients who are undergoing a residential Dialectical Behavior Therapy (DBT) program, a standard treatment of BPD (Bohus et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: Proof-of-concept in borderline personality disorder

Zopfs

Jindrová

Gurevitch

et al. 2023

Preprint

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Background: The modulation of brain circuits of emotion is a promising pathway to treat Borderline Personality Disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the Amygdala Electrical Fingerprint (Amyg-EFP) in BPD are presented: One study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation. Methods: Study 1 combined EEG and simultaneous fMRI to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (N=24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (N=16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the Research Domain Criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential Dialectical Behavior Therapy (DBT) program. N=15 patients with BPD completed the training, N=15 matched patients served as DBT-only controls. Results: Study 1 replicated previous findings and showed significant amygdala BOLD-activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed significant learning of Amyg-EFP modulation with NF training. No clinical benefits of NF beyond DBT-only were observed. Conclusions: Recorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: Proof-of-concept in borderline personality disorder

Zopfs

Jindrová

Gurevitch

et al. 2023

Preprint

Self Cite

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“…In this way, amygdala down-regulation could enhance clinical efficacy. [28] By taking meditation, through decreased amygdala activation, the training may enhance emotional responsiveness. [29] During the intervention process, the method of the Warrior Mind Training program was used for those active firefighters who experienced traumatized symptoms and insomnia in a large proportion (59.09% of insomnia in Figure 2 and 61.90% of presence of traumatized reaction in Figure 3).…”

Section: Discussionmentioning

confidence: 99%

Utilizing Meditation Audio in Warrior Mind Training Treat Traumatized Firefighters

Zou¹

2022

BCPSSH

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Meditation is a psychological concept that has become a hot topic recently in the field of neuroscience. Based on many fundamental and crucial experiments or research, people discovered that meditation, however, is a stress buster that helps people to alleviate the symptoms of anxiety disorders spectrums with its scientific mechanisms that are studied. When it comes to firefighters frequently exposed to traumatic fire scenes and at risk of being traumatized, chances are high that meditation will be a pragmatic way of improving their resistance when exposed to the trauma without any side effects caused by its medication. This paper examines the effectiveness of meditation in alleviating PTSD or traumatized symptoms for firefighters with the use of two psychological scales, analyzing and categorizing each result in the statistic. By listening to the meditation audio, the symptoms of insomnia and anxiety have been assuaged, shown by the post-intervention group with p=0.099<0.1, χ2 =4.63 in insomnia-scale measurement, as well as p=0.079<0.1, χ2 = 3.086 in traumatized-scale measurement, embodying the effectiveness of meditation in alleviating traumatized symptoms and insomnia severity as prediction (P was set at 0.1).

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“…The authors hypothesize that the decreased frontal activity was a result of premature strategy selection resulting in increased baseline activation in preparation for reappraisal training. The reduced amygdala response was expected, and another paper in the special issue reported that training to reduce an EEG signature of the amygdala response during the experience of trauma related stimuli showed promising results in a group of patients with PTSD ( Fruchtman-Steinbok et al, 2021 ). This study did not include a sham control group, however, and conclusions regarding the clinical efficacy of this particular neurofeedback protocol cannot be reached.…”

Section: Clinical Trialsmentioning

confidence: 96%

Editorial: Clinical Neurofeedback

Young

Johansen‐Berg²

2022

NeuroImage: Clinical

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Amygdala electrical-finger-print (AmygEFP) NeuroFeedback guided by individually-tailored Trauma script for post-traumatic stress disorder: Proof-of-concept

Cited by 25 publications

References 48 publications

Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: Proof-of-concept in borderline personality disorder

Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: Proof-of-concept in borderline personality disorder

Utilizing Meditation Audio in Warrior Mind Training Treat Traumatized Firefighters

Editorial: Clinical Neurofeedback

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