Amplitude and Variability of Monosynaptic Reflexes Prior to Various Voluntary Movements in Normal and Spastic Man

Pierrot-Deseilligny, E; Lacert, P

doi:10.1159/000394166

Cited by 23 publications

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“…1 (Hoffmann, 1918) or before (Pierrot-Deseilligny, Lacert & Cathala, 1971) voluntary contraction of the pretibial flexors is well-known. This inhibition is probably due in part to the activation of reciprocal Ia inhibition (Tanaka, 1974), although presynaptic inhibition of soleus Ia fibres by the Ia discharge from pretibial flexors has also been postulated to contribute to it (Gottlieb, Agarwal & Stark, 1970;Pierrot-Deseilligny & Lacert, 1973). Regardless of its mechanism, this inhibition of the soleus H reflex contributes to the decrease in the H' test reflex illustrated in Fig.…”

Section: Resultsmentioning

confidence: 99%

Facilitation of soleus‐coupled Renshaw cells during voluntary contraction of pretibial flexor muscles in man.

Katz¹,

Pierrot-Deseilligny²

1984

The Journal of Physiology

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SUMMARY1. Recurrent inhibition to soleus motoneurones, brought about by a conditioning H-reflex discharge, was estimated in human subjects by a subsequent test H reflex. Changes in recurrent inhibition during voluntary ankle dorsiflexion were evaluated by comparing the amplitude of the test H reflex to a reference H reflex: both reflexes were subjected to the same type of influences which modified soleus monosynaptic reflex excitability during pretibial flexor contraction, but only the test H reflex was subject to the recurrent inhibition evoked by the conditioning H-reflex discharge.2. During tonic or phasic ramp contractions of the pretibial flexors the inhibition of the test H reflex, as compared to rest, was more marked than that of the reference H reflex. Evidence is presented that this may indicate a facilitation of soleus-coupled Renshaw cells. Since this facilitation of soleus-coupled Renshaw cells was also observed before ramp contraction, it is, at least in part, supraspinal in origin.3. Within the range of forces studied (8-45 % of maximum force) there was no evidence that the facilitation of soleus-coupled Renshaw cells increased along with increased force of the pretibial flexor voluntary contraction. During voluntary phasic ankle dorsiflexion, facilitation of soleus-coupled Renshaw cells was maximum at the moment when soleus motoneurones were most facilitated by the stretch-induced soleus Ia discharge. There was no evidence for changes in Renshaw cell excitability during ballistic contractions.4. It is suggested that this facilitation of soleus-coupled Renshaw cells may be one of the mechanisms preventing the occurrence of a soleus stretch reflex during a voluntary ankle dorsiflexion. Such a mechanism could become important if reciprocal inhibition, via Ia inhibitory interneurones, were not strong enough, e.g. because of a weak y-drive to the contracting muscles.

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Section: Resultsmentioning

confidence: 99%

Facilitation of soleus‐coupled Renshaw cells during voluntary contraction of pretibial flexor muscles in man.

Katz¹,

Pierrot-Deseilligny²

1984

The Journal of Physiology

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“…The mechanisms of this inhibition are attributed to Ia inhibition and presynaptic inhibition, activated by a central descending motor command (Crone and Nielsen, 1989b). Reduced inhibition of the soleus H-reflex at the onset of dorsiflexion in spastic patients has been reported (Boorman et al, 1996;Pierrot-Deseilligny and Lacert, 1973;Kagamihara and Tanaka, 1996;Morita et al, 2001). Morita et al (2001) reported that reduced inhibition at the onset of movement in patients with spastic multiple sclerosis was due to abnormal regulation of Ia inhibition and presynaptic inhibition by a central descending command.…”

Section: Discussionmentioning

confidence: 96%

Excitability of Spinal Inhibitory Circuits in Patients with Spasticity

Kagamihara

Masakado²

2005

Journal of Clinical Neurophysiology

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The excitability of Ia inhibition and D1 inhibition after stimulation of the common peroneal nerve to the soleus motoneuron pool was investigated in 37 spastic patients at rest and onset of voluntary ankle dorsiflexion. Ia inhibition was determined as the short-latency depression of the soleus H-reflex and D1 inhibition as the long-latency depression. There was no significant difference in Ia inhibition between the paraplegic and control groups, however Ia inhibition in the hemiplegic group was significantly decreased. D1 inhibition was reduced in the paraplegic and hemiplegic groups compared with controls. Although inhibition of the soleus H-reflex appeared at the onset of voluntary dorsiflexion in control subjects, it was not observed in the patients. Although the excitability of the Ia inhibitory pathway at rest in the patients did not differ from that in control subjects, facilitation of the Ia inhibitory pathway at the onset of movement was decreased in the patients. Ia inhibition and D1 inhibition were evaluated in two paraplegic patients who were treated with local anesthesia and surgery, respectively. The excitability of both inhibitory pathways at rest was unchanged despite improvement of reciprocal movement in one patient, and was enhanced despite reduction in muscle strength in the other patient. The excitability of spinal inhibitory pathways at rest was not always reflected by motor function in spastic patients.

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“…H reflex testing provides an indirect measure of the excitability levels of alpha motoneurons, since the amplitude of the H wave is directly proportional to the number of motoneurons activated. Recent developments in H reflex testing methods have made it possible to study, in man, mechanisms involved in reciprocal inhibition, Renshaw cell inhibition and presynaptic inhibition (Pierrot-Deseilligny and Lacert 1973, Tanaka 1974, Pierrot-Deseilligny et al 1983, Crone et al 1987, Hultborn et al 1987.…”

Section: Charles T Leonard Toshio Moritani Helga Hirsch Feld Hans Fomentioning

confidence: 99%

Deficits in Reciprocal Inhibition of Children With Cerebral Palsy as Revealed by H Reflex Testing

Leonard

Moritani

Hirschfeld

et al. 1990

Develop Med Child Neuro

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SUMMARY Experiments were performed to determine whether spinal and supraspinal components of reciprocal inhibition (a neural mechanism responsible for the prevention of muscular co‐ordination during voluntary movement) were present in groups of non‐disabled children and children with cerebral palsy. Changes in the gastrocnemius‐soleus H reflex were examined during voluntary dorsiflexion and plantarflexion of the ankle and during a vibration applied to the anterior tibial tendon. The results indicate that children with cerebral palsy have impairments in reciprocal inhibition, both before and during voluntary movement. These deficits, which involve damage to supraspinal centres, contribute to their inability to perform smooth, co‐ordinated movements. RÉSUMÉ Déficits de l'inhibition réciproque chez les enfants avec infirmité motrice cérébrale révélés par l'exploration de refluxe H Une expérimentation a été réalisée pour déterminer si les composantes spinales et supra‐spinales de l'inhibition réciproque (mécanisme neuronique responsable de la prévention d'une co‐contraction musculaire durant le mouvement volontaire) étaient présentes chez les adolescents et les enfants avec infirmité motrice cérébrale. Les changements dans le reflexe H du triceps sural ont été examinés durant la flexion volontaire dorsale et planaire de la cheville et durant une vibration appliquée au tendon du jambier antérieur. Les résultats indiquent que les enfants porteurs d'IMC présentent des troubles de l'inhibition réciproque à la fois avant et durant le mouvement volontaire. Ces déficits liés à des lésions des centres supra‐spinaux, contribuent à l'incapacité de réaliser des mouvements souples et coordonnés. ZUSAMMENFASSUNG Störungen der reziproken Inhibition bei Kindern mit Cerebralparese, festgestellt durch H‐Reflex Testung Es war das Ziel dieser Untersuchungen, festzustellen, ob bei Jugendlichen und Kindern mit Cerebralparese spinale und supraspinale Komponenten der reziproken Inhibition (ein neuraler Mechanismus, der die muskuläre Kokontraktion bei der willkürlichen Bewegung verhindert) vorhanden sind. Die Veränderungen beim Gastrocnemius‐Soleus H Reflex wurden bei der willkürlichen Dorsal‐ und Plantarflexion im Knöchelgelenk und bei Vibrationen auf die Sehne des M. tibiales anterior untersucht. Die Ergebnisse zeigen, daß die reziproke Inhibition bei Kindern mit Cerebralparese vor und während einer willkürkürlichen Bewegung gestört ist. Diese Störungen, die durch eine Schädigung der supraspinalen Zentren bedingt sind, sind dafür verantwortlich, daß die Kinder nicht in der Lage sind, weiche koordinierte Bewegungen auszuführen. RESUMEN Déficids en la inhibición recíproca en niños con parálisis cerebral revelada por la exploración del reflejo H Se realizaron experimentos para determinar si los componentes espinal y supraespinal de la inhibición recíproca (un mecanismo neural responsable de la prevención de la co‐contraccion muscular durante el moviminto voluntario) estaban presentes en el adolescente y el niño con parálisis cerebral. Se exa...

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Amplitude and Variability of Monosynaptic Reflexes Prior to Various Voluntary Movements in Normal and Spastic Man

Cited by 23 publications

References 0 publications

Facilitation of soleus‐coupled Renshaw cells during voluntary contraction of pretibial flexor muscles in man.

Facilitation of soleus‐coupled Renshaw cells during voluntary contraction of pretibial flexor muscles in man.

Excitability of Spinal Inhibitory Circuits in Patients with Spasticity

Deficits in Reciprocal Inhibition of Children With Cerebral Palsy as Revealed by H Reflex Testing

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