Amplification of Lipid Peroxidation by Regulating Cell Membrane Unsaturation To Enhance Chemodynamic Therapy

Yang, Zhu; Gong, Peng; Wang, Jun; Cheng, Junjie; Wang, Wenyu; Cai, Huilan; Ao, Rujiang; Huang, Hongwei; Yu, Meili; Lin, Lisen; Chen, Xiaoyuan

doi:10.1002/anie.202218407

Cited by 64 publications

(38 citation statements)

References 69 publications

(21 reference statements)

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“…Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining was performed to detect apoptotic tumor cells (Figure 6a). [26] More TUNEL-positive cells appeared in the ADT@CuSNDs plus laser group, and tumor nuclei were loosely arranged following combination treatment, demonstrating the outstanding antitumor activity of ADT@CuSNDs, which induced a high rate of apoptosis in cancer cells. This result could also be obtained from the analysis of H&E staining (Figure S25, Supporting Information).…”

Section: Methodsmentioning

confidence: 91%

Gas‐Mediated Tumor Energy Remodeling for Sensitizing Mild Photothermal Therapy

et al. 2023

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The metabolic reprogramming of tumors requires high levels of adenosine triphosphate (ATP) to maintain therapeutic resistance, posing a major challenge for photothermal therapy (PTT). Although raising the temperature helps in tumor ablation, it frequently leads to severe side effects. Therefore, improving the therapeutic response and promoting healing are critical considerations in the development of PTT. Here, we proposed a gas‐mediated energy remodeling strategy to improve mild PTT efficacy while minimizing side effects. In the proof‐of‐concept study, a Food and Drug Administration (FDA)‐approved drug‐based hydrogen sulfide (H2S) donor was developed to provide a sustained supply of H2S to tumor sites, serving as an adjuvant to PTT. This approach proved to be highly effective in disrupting the mitochondrial respiratory chain, inhibiting ATP generation, and reducing the overexpression of heat shock protein 90 (HSP90), which ultimately amplified the therapeutic outcome. With the ability to reverse tumor thermotolerance, this strategy delivered a greatly potent antitumor response, achieving complete tumor ablation in a single treatment while minimizing harm to healthy tissues. Thus, it holds great promise to be a universal solution for overcoming the limitations of PTT and may serve as a valuable paradigm for the future clinical translation of photothermal nanoagents.

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Section: Methodsmentioning

confidence: 91%

Gas‐Mediated Tumor Energy Remodeling for Sensitizing Mild Photothermal Therapy

et al. 2023

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“…Recently, our group developed a single‐atom Fe‐anchored hollow carbon nanosphere loaded with oleanolic acid (OA) and surrounded by erythrocyte membranes (OA@Fe‐SAC@EM), which amplified LPO to enhance tumor ferroptosis by regulating cell membrane unsaturation ( Figure ). [ 49 ] Specifically, OA@Fe‐SAC@EM could effectively catalyze endogenous H 2 O 2 into highly active •OH via the Fenton reaction in the TME, enabling erythrocyte membrane disruption and OA release. The OA greatly upregulated the expression of Acyl‐CoA synthetase long chain family member 4 (ACSL4) and subsequently increased the amount of polyunsaturated fatty acids (PUFAs) on cell lipid membranes.…”

Section: Biomedical Applications Of Sazymesmentioning

confidence: 99%

“…[89] Chen et al reported an oleanolic acid (OA)-loaded Fe SAzyme for self-reinforcing chemodynamic therapy. [49] To meet the biomedical needs, the SAzyme was coated with RBC membrane to obtain the OA@Fe-SAC@EM nanoparticles (NPs). The dynamic light scattering (DLS) results showed that RBC membrane shell significantly improved the stability of Fe SAzymes under physiological conditions.…”

Section: Surface Engineeringmentioning

confidence: 99%

Engineering Single‐Atom Nanozymes for Catalytic Biomedical Applications

Yang

Liao

Zou

et al. 2023

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Nanomaterials with enzyme‐mimicking properties, coined as nanozymes, are a promising alternative to natural enzymes owing to their remarkable advantages, such as high stability, easy preparation, and favorable catalytic performance. Recently, with the rapid development of nanotechnology and characterization techniques, single atom nanozymes (SAzymes) with atomically dispersed active sites, well‐defined electronic and geometric structures, tunable coordination environment, and maximum metal atom utilization are developed and exploited. With superior catalytic performance and selectivity, SAzymes have made impressive progress in biomedical applications and are expected to bridge the gap between artificial nanozymes and natural enzymes. Herein, the recent advances in SAzyme preparation methods, catalytic mechanisms, and biomedical applications are systematically summarized. Their biomedical applications in cancer therapy, oxidative stress cytoprotection, antibacterial therapy, and biosensing are discussed in depth. Furthermore, to appreciate these advances, the main challenges, and prospects for the future development of SAzymes are also outlined and highlighted in this review.

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“…A recent study by Zhu et al focused on amplifying such lipid peroxidation to maximize the CDT-induced damage to cancer cells. 133 The novelty lies in the exploitation of the properties of polyunsaturated fatty acids (PUFAs) that are particularly more susceptible to ROS-induced lipid peroxidation compared to saturated and monounsaturated fatty acids. To increase the fatty acid unsaturation in cancer cell membranes, they developed erythrocyte membrane-encapsulated hollow carbon nanospheres that contained Fe single-atom catalysts and oleanolic acid.…”

Section: Strategies To Improve Cdt Efficiencymentioning

confidence: 99%