Amplification and the clinical significance of circulating cell-free DNA of PVT1 in breast cancer

Li, Xujing; Chen, Weijuan; Wang, Hui; Wang, Qun; Ding, Xiaodi; Li, Wentong

doi:10.3892/or.2017.5650

Cited by 14 publications

(13 citation statements)

References 21 publications

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“…Plasmacytoma variant translocation 1 ( PVT1 ) localizes downstream of the MYC gene and maps to chromosome 8q24. PVT1 specifically facilitates the invasive pathophysiology of ovarian cancer, 27 breast cancer, 28 and esophageal squamous cell carcinoma, 29 and overexpression of PVT1 is an effective predictor of oncogenesis and overall survival in patients with multifarious cancers, including colorectal cancer 30 and gastric cancer. 31 However, the association between the abnormal expression and biological functions of PVT1 in CCA and the underlying mechanisms remains undiscovered.…”

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNA PVT1 Promotes Cell Proliferation and Migration by Silencing ANGPTL4 Expression in Cholangiocarcinoma

Zhang

Liu

et al. 2018

Molecular Therapy - Nucleic Acids

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Cholangiocarcinoma (CCA) is the most common biliary tract malignancy, with a low survival rate and limited treatment options. Long non-coding RNAs (lncRNAs) have recently been verified to have significant regulatory functions in many kinds of human cancers. It was discovered in this study that the lncRNA PVT1, whose expression is significantly elevated in CCA, could be a molecular marker of CCA. Experiments indicated that PVT1 knockdown greatly inhibited cell migration and proliferation in vitro and in vivo. According to RNA sequencing (RNA-seq) analysis, PVT1 knockdown dramatically influenced target genes associated with cell angiogenesis, cell proliferation, and the apoptotic process. RNA immunoprecipitation (RIP) analysis demonstrated that, by binding to epigenetic modification complexes (PRC2), PVT1 could adjust the histone methylation of the promoter of ANGPTL4 (angiopoietin-like 4) and, thus, promote cell growth, migration, and apoptosis progression. The data verified the significant functions of PVT1 in CCA oncogenesis, and they suggested that PVT1 could be a target for CCA intervention.

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Section: Introductionmentioning

confidence: 99%

Long Non-coding RNA PVT1 Promotes Cell Proliferation and Migration by Silencing ANGPTL4 Expression in Cholangiocarcinoma

Zhang

Liu

et al. 2018

Molecular Therapy - Nucleic Acids

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“…An assessment of the effect of PVT1 on p21 expression in PANC-1 cells revealed a significantly increase in p21 at the transcriptional level when PVT1 was suppressed (33). Additionally, the tumor promoting activity of PVT1 was confirmed to be partially dependent on the negatively regulation on p21 in breast cancer (52).…”

Section: Pvt1: a Regulator Of The Cell Cyclementioning

confidence: 91%

Oncogenic Role of PVT1 and Therapeutic Implications

et al. 2020

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PVT1, a long non-coding RNA has been implicated in a variety of human cancers. Recent advancements have led to increasing discovery of the critical roles of PVT1 in cancer initiation and progression. Novel insight is emerging about PVT1's mechanism of action in different cancers. Identifying and understanding the variety of activities of PVT1 involved in cancers is a necessity for the development of PVT1 as a diagnostic biomarker or therapeutic target in cancers where PVT1 is dysregulated. PVT1's varied activities include overexpression, modulation of miRNA expression, protein interactions, targeting of regulatory genes, formation of fusion genes, functioning as a competing endogenous RNA (ceRNA), and interactions with MYC, among many others. Furthermore, bioinformatic analysis of PVT1 interactions in cancers has aided understanding of the numerous pathways involved in PVT1 contribution to carcinogenesis in a cancer type-specific manner. However, these recent findings show that there is much more to be learned to be able to fully exploit PVT1 for cancer prognostication and therapy. In this review, we summarize some of the latest findings on PVT1's oncogenic activities, signaling networks and how targeting these networks can be a strategy for cancer therapy.

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“…It contains 1716 nucleotides and is located on chromosome 8q24.21 (Zeidler et al, 1994). After its discovery, the roles of PVT1 have been identified in various cancers, including BDC, BRC, LC, MPM, and NSCLC (Cui et al, 2016; Li et al, 2017d; Lu et al, 2017; Zhang X.W. et al, 2017; Zhou et al, 2017; Guo et al, 2018; Li H. et al, 2018).…”

Section: Autophagy-inducing Lncrnas In Cancermentioning

confidence: 99%

“…According to GENCODE (version 18), 13,562 lncRNAs have been identified (Huang X. et al, 2017). LncRNAs have independent expressions in different tissues and different cancers and are responsible for various cancers including BRC, CRC, GC, glioma, HCC, leukemia, LVC, LC, OVC, PTC, and retinoblastoma (He et al, 2016; Huang J. et al, 2017; Huang X. et al, 2017; Li et al, 2017b,d,e; Luo et al, 2017; Ma et al, 2017d; Jiang et al, 2018; Li H. et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Autophagy-Modulating Long Non-coding RNAs (LncRNAs) and Their Molecular Events in Cancer

2019

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Cancer is a global threat of health. Cancer incidence and death is also increasing continuously because of poor understanding of diseases. Although, traditional treatments (surgery, radiotherapy, and chemotherapy) are effective against primary tumors, death rate is increasing because of metastasis development where traditional treatments have failed. Autophagy is a conserved regulatory process of eliminating proteins and damaged organelles. Numerous research revealed that autophagy has dual sword mechanisms including cancer progressions and suppressions. In most of the cases, it maintains homeostasis of cancer microenvironment by providing nutritional supplement under starvation and hypoxic conditions. Over the past few decades, stunning research evidence disclosed significant roles of long non-coding RNAs (lncRNAs) in the regulation of autophagy. LncRNAs are RNA containing more than 200 nucleotides, which have no protein-coding ability but they are found to be expressed in most of the cancers. It is also proved that, autophagy-modulating lncRNAs have significant impacts on pro-survival or pro-death roles in cancers. In this review, we highlighted the recently identified autophagy-modulating lncRNAs, their signaling transduction in cancer and mechanism in cancer. This review will explore newly emerging knowledge of cancer genetics and it may provide novel targets for cancer therapy.

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Amplification and the clinical significance of circulating cell-free DNA of PVT1 in breast cancer

Cited by 14 publications

References 21 publications

Long Non-coding RNA PVT1 Promotes Cell Proliferation and Migration by Silencing ANGPTL4 Expression in Cholangiocarcinoma

Long Non-coding RNA PVT1 Promotes Cell Proliferation and Migration by Silencing ANGPTL4 Expression in Cholangiocarcinoma

Oncogenic Role of PVT1 and Therapeutic Implications

Autophagy-Modulating Long Non-coding RNAs (LncRNAs) and Their Molecular Events in Cancer

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