Abstract:AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins in order to maintain cellular homeostasis. AMPK consists of three subunits: α, β and γ. AMPKα and β are encoded by two genes, the γ subunit by three genes, all of which being expressed in a tissue-specific manner. If individual isoforms have different functions is not understood so far. Using RNA-Seq technology, we provide evidence that the loss of AMPKβ1 and AMPKβ2 lead to different gene ex… Show more
“…JMJD3 may be involved in the determination of the cardiomyogenic lineage from mouse ESCs and enhanced the expression levels of Jmjd3, Jmjd2a, and Jhdm1d [ 66 ]. The transcription factor insulin gene enhancer-binding protein 1 (ISL1) plays a key role in cardiac lineage differentiation [ 67 ]. It has been found that ISL1 cooperates with JMJD3 to alter the cardiac epigenome and regulate cardiac differentiation of ESCs [ 65 ].…”
Section: Jmjd3 Function In Embryonic Stem Cellsmentioning
The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with transcriptional silencing. JMJD3 has been studied extensively in immune diseases, cancer, and tumor development. There is a comprehensive epigenetic transformation during the transition of embryonic stem cells (ESCs) into specialized cells or the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs). Recent studies have illustrated that JMJD3 plays a major role in cell fate determination of pluripotent and multipotent stem cells (MSCs). JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and MSCs. In this review, we will focus on the recent advances of JMJD3 function in stem cell fate.
“…JMJD3 may be involved in the determination of the cardiomyogenic lineage from mouse ESCs and enhanced the expression levels of Jmjd3, Jmjd2a, and Jhdm1d [ 66 ]. The transcription factor insulin gene enhancer-binding protein 1 (ISL1) plays a key role in cardiac lineage differentiation [ 67 ]. It has been found that ISL1 cooperates with JMJD3 to alter the cardiac epigenome and regulate cardiac differentiation of ESCs [ 65 ].…”
Section: Jmjd3 Function In Embryonic Stem Cellsmentioning
The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with transcriptional silencing. JMJD3 has been studied extensively in immune diseases, cancer, and tumor development. There is a comprehensive epigenetic transformation during the transition of embryonic stem cells (ESCs) into specialized cells or the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs). Recent studies have illustrated that JMJD3 plays a major role in cell fate determination of pluripotent and multipotent stem cells (MSCs). JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and MSCs. In this review, we will focus on the recent advances of JMJD3 function in stem cell fate.
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