SNP discovery of <i>PRKAB1</i> gene and their associations with growth traits in goats

Zhou, Shengliang; Shi, Xinying; Song, Chengchuang; Wang, Yanhong; Lai, Min; Chen, Xi; Zhang, Chunlei; Chen, Hong; Fang, Xinggen

doi:10.1080/10495398.2021.1920426

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Recent studies have revealed complex genetic relationships between wild and domesticated populations and the development of advanced genetic sequencing technologies have allowed researchers to study the genomes of geese in unprecedented detail, unlocking new insights into the evolutionary history of these birds (Heikkinen et al, 2015; Ouyang et al, 2022; Ren et al, 2016). Through comparative genomic analysis, previous studies have identified several domestication selection genes, such as PRKAB1 and PRKAG2 , which are related to growth and development, feed intake and meat feed efficiency, as well as pathways involved in growth reproductive metabolism regulation (Liu et al, 2021; Zhou et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Genomic signatures reveal selection in Chinese and European domesticated geese

Zhang,

Li,

Tang

et al. 2023

Animal Genetics

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The Swan goose and Greylag goose are species of geese native to East Asia and Europe, respectively, and are widely believed to be the ancestors of Chinese and European domesticated geese. The Yili goose (YL) and European domestic geese originated from the Greylag goose, but the history of domestication is unclear. In this study, we sequenced and analyzed the genome of the YL goose and the Hortobagy goose to combine with other previously sequenced goose populations for in‐depth analysis. The population genetic variations in Stone geese, East Zhejiang White Geese, Taihu geese and Zi geese were also identified and compared. The results showed that admixture gene flow existed in the YL geese population, which was introgressed by Chinese geese, suggesting that gene flow events were frequent and widespread among domesticated geese. Further selected sweep analysis identified candidate genes and metabolic pathways that may be related to the differences in morphology. Several genes such as TGFBR3L, CMYA5, FOXD1, ARHGEF28 and SUCLG2 are associated with growth, reproduction and fertility traits. The results of this study will help to understand the genetic characteristics of domestic geese and the genes affecting important traits and provide a basis for the improved breed of domestic geese.

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Section: Introductionmentioning

confidence: 99%

Genomic signatures reveal selection in Chinese and European domesticated geese

Zhang,

Li,

Tang

et al. 2023

Animal Genetics

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Polymorphism and expression level of the FADS3 gene and associated with the growth traits in Hu sheep

Zeng

Wang

Zhang

et al. 2023

Animal Biotechnology

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Deciphering the Genetic Landscape: Insights Into the Genomic Signatures of Changle Goose

Chen,

Wu,

Zhu

et al. 2024

Evolutionary Applications

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The Changle goose (CLG), a Chinese indigenous breed, is celebrated for its adaptability, rapid growth, and premium meat quality. Despite its agricultural value, the exploration of its genomic attributes has been scant. Our study entailed whole‐genome resequencing of 303 geese across CLG and five other Chinese breeds, revealing distinct genetic diversity metrics. We discovered significant migration events from Xingguo gray goose to CLG and minor gene flow between them. We identified genomic regions through selective sweep analysis, correlating with CLG's unique traits. An elevated inbreeding coefficient in CLG, alongside reduced heterozygosity and rare single nucleotide polymorphisms (RSNPs), suggests a narrowed genetic diversity. Genomic regions related to reproduction, meat quality, and growth were identified, with the GATA3 gene showing strong selection signals for meat quality. A non‐synonymous mutation in the Sloc2a1 gene, which is associated with reproductive traits in the CLG, exhibited significant differences in allelic frequency. The roles of CD82, CDH8, and PRKAB1 in growth and development, alongside FABP4, FAF1, ESR1, and AKAP12 in reproduction, were highlighted. Additionally, Cdkal1 and Mfsd14a may influence meat quality. This comprehensive genetic analysis underpins the unique genetic makeup of CLG, providing a basis for its conservation and informed breeding strategies.

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SNP discovery of PRKAB1 gene and their associations with growth traits in goats

Cited by 3 publications

References 26 publications

Genomic signatures reveal selection in Chinese and European domesticated geese

Genomic signatures reveal selection in Chinese and European domesticated geese

Polymorphism and expression level of the FADS3 gene and associated with the growth traits in Hu sheep

Deciphering the Genetic Landscape: Insights Into the Genomic Signatures of Changle Goose

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