Ampicillin-Resistant Listeria monocytogenes Meningitis in a Previously Healthy 14-Year-Old Athlete

Rapp, Michael F.; Pershadsingh, Harrihar A.; Long, James W.; Pickens, James M.

doi:10.1001/archneur.1984.04050230090030

Cited by 22 publications

(11 citation statements)

References 3 publications

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“…MICs of penicillin G were similar to those of ampicillin. Although several ampicillin-resistant (17,20) and penicillin-resistant (23) strains of L. monocytogenes have been reported in clinical isolates, all the strains tested by us were susceptible to these beta-lactams. Our data for ampicillin are similar to those reported by Marinova (14) and others (3,10) for L. monocytogenes.…”

mentioning

confidence: 62%

Susceptibilities of Listeria species isolated from food to nine antimicrobial agents

Abuín¹,

Fernández²,

Sampayo³

et al. 1994

Antimicrob Agents Chemother

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The agar dilution method was used to determine the activities of gentamicin, erythromycin, streptomycin, chloramphenicol, ampicillin, sulfamethazine, cephalothin, penicillin G, and tetracycline against 73 strains belonging to the genus Listeria (L. innocua, L. seeligeri, and L. monocytogenes). All strains were isolated from raw milk, cheese, the dairy processing plant, poultry, and the poultry slaughterhouse. Gentamicin, ampicillin, and erythromycin, of which the MICs for 90% of the strains tested for all three species were .5.96 ,ug/ml, were found to be the most active agents studied. Most of the L. innocua strains isolated from poultry and the poultry slaughterhouse were resistant to tetracycline.Listeriosis is an infectious disease which affects both humans and animals. Most cases of human listeriosis appear to be sporadic, although a portion of these sporadic cases may be previously unrecognized common-source clusters (4). The source and route of infection are usually unknown. However, the recent ass §iciation of Listenia monocytogenes with several large food-borne outbreaks (8,11) suggests that contaminated food may be the primary source of the organism.Penicillin or ampicillin, alone or in combination with an aminoglycoside, seems to be the drug of choice (5); a trimethoprim-sulfamethoxazole combination has also been used (13). Although most clinical isolates of L. monocytogenes are susceptible in vitro to penicillin, ampicillin, tetracycline, and other antimicrobial agents, few quantitative studies have been carried out to determine the in vitro susceptibilities of Listeria spp. isolated from food. The purpose of the present study was to determine the susceptibilities of 73 strains of the genus Listeria, all isolated from food and food-processing plant environments, to nine antimicrobial agents: gentamicin, erythromycin, streptomycin, chloramphenicol, ampicillin, penicillin G, cephalothin, sodium sulfamethazine, and tetracycline.The study was carried out with 73 strains belonging to the genus Listeria. The strains were isolated by us from raw milk and cheese obtained from several markets, the environment from one dairy plant, the environment from one poultry slaughterhouse, and poultry from the same slaughterhouse. Numbers of strains of each Listeria species for each source and dates of isolation are shown in Listeria strains isolated from raw milk, cheese, the dairy plant, poultry, and the poultry slaughterhouse are shown in Table 2.The concentrations of gentamicin to which the Listeria innocua and Listeria seeligeri strains isolated in this study were susceptible ranged from 0.74 to 2.98 jig/ml. Results similar to those obtained in the present study have been reported for L. monocytogenes (3,10

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mentioning

confidence: 62%

Susceptibilities of Listeria species isolated from food to nine antimicrobial agents

Abuín¹,

Fernández²,

Sampayo³

et al. 1994

Antimicrob Agents Chemother

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“…In 1984 Rapp et al [35] and in 1986 Pol lock et al [36] reported on ampicillin resistant isolates. In 1995 Soriano et al [37] noted an increase in the MIC values of ampicillin forL.…”

Section: In Vitro Susceptibility Of Listeria Monocytogenesmentioning

confidence: 99%

In vitro Susceptibility of <i>Listeria monocytogenes</i>: Comparison of the E Test with the Agar Dilution Test

Heger

Dierich

Allerberger³

1997

Chemotherapy

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In vitro susceptibility testing was performed on 66 strains of Listeria monocytogenes. Recently obtained clinical isolates from Austria, France, Norway and Switzerland and 17 reference strains from three type culture collections were tested against ampicillin, gentamicin, trimethoprim-sulfamethoxazole, ampicillin-sulbactam, meropenem, and first-, second-, third- and fourth-generation cephalosporins. All isolates were susceptible to ampicillin, gentamicin, and trimethoprim-sulfamethoxazole, ampicillin-sulbactam, and meropenem and more than 86% of the minimal inhibitory concentration E test values were within plus/minus one dilution step of the agar dilution test. In vitro susceptibility of L. monocytogenes has not changed markedly during the last decades; the level of susceptibility of old reference strains did not differ from that of recently encountered clinical isolates. The E test seems to be a suitable method for Listeria.

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“…Six hundred and twentyone strains of Listeria monocytogenes isolated from clinical infections in the UK were tested, and no strains demonstrated resistance to ampicillin, gentamicin or chloramphenicol; however, 2 % were resistant to tetracycline, and a single isolate was erythromycin resistant (111). It is unclear whether the occasional reports of ampicillin resistance are actually due to changes in the PBP3 (112,113). In the UK, Listeria rnonocytogenes continues to be sensitive to most antibiotics, and therefore it is debatable whether routine sensitivity tests by disc diffusion methods need to be performed, especially as there are no interpretive criteria for Listeria monocytogenes.…”

Section: Antimicrobial Resistancementioning

confidence: 99%

Antimicrobial chemotherapy of human infection due toListeria monocytogenes

Jones¹,

MacGowan²

1995

Eur. J. Clin. Microbiol. Infect. Dis.

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Listeriosis is an uncommon infection, but when it occurs it carries a high mortality rate. Early diagnosis is essential and thereafter appropriate antimicrobial chemotherapy. Ampicillin or penicillin plus gentamicin remains the treatment of choice for most manifestations of listeriosis, and adequate doses must be given, i.e. greater than 6g/day of ampicillin or penicillin. Co-trimoxazole appears to be an excellent alternative agent with good penetration into the cerebrospinal fluid. Vancomycin is an appropriate agent for the treatment of primary bacteraemia but does not cross the blood-brain barrier sufficiently well to be useful in meningitis, while erythromycin may be used to treat listeriosis in cases of pregnancy. Treatment of bacteraemia requires one to two weeks' therapy, while meningitis cases may need to be treated for longer; for example, it has been found that most patients with acute meningitis in the UK were treated for 20 days. Infective endocarditis needs treatment for six to eight weeks. Doses should be varied with patients' altered organ function and antimicrobial serum monitoring performed when appropriate.

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Ampicillin-Resistant Listeria monocytogenes Meningitis in a Previously Healthy 14-Year-Old Athlete

Cited by 22 publications

References 3 publications

Susceptibilities of Listeria species isolated from food to nine antimicrobial agents

Susceptibilities of Listeria species isolated from food to nine antimicrobial agents

In vitro Susceptibility of <i>Listeria monocytogenes</i>: Comparison of the E Test with the Agar Dilution Test

Antimicrobial chemotherapy of human infection due toListeria monocytogenes

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