Ampicillin Rash in Children

Abstract

Of 370 children receiving ampicillin, 35 (9.46%) developed a skin rash. Nineteen of these children and 19 who received ampicillin but did not develop rash were observed. One patient from each group had serologic evidence of Epstein-Barr virus infection. No child with ampicillin rash had a positive skin test to ampicillin or penicillin major or minor determinants. Fourteen children with rash continued ampicillin therapy with no ill effects and with disappearance of the rash

Erythematous Eruption of the Palms and Soles Associated with Mitotane Therapy

“…At the time the changes began, the only other medications he used were cortisol and Maalox. The onset of palmar lesions two days after mitotane was discontinued may cast some doubt on a cause and effect relationship of mitotane to his eruption; however, some drug induced changes do not appear until the drug is discontinued, e.g., some ampicillin eruptions [2,4,5], According to H utter and K ayhoe [3], mitotane eruptions do not appear to be dose-related in all instances. Some of their patients developed an eruption which disappeared while treatment was continued.…”

Allergy to Antibiotics in Children: Who Is to Blame and What to Do?

“…As far as clinical manifestations of this type of drug hypersensitivity are well known, we are not considering them in detail in this review; we draw attention to several other drug hypersensitivity manifestations, which may be frequent or rare, but certainly significant from the clinical point of view. The phenomenon of the so called ampicillin rash cannot be ignored; it is a widespread reaction to antibiotics, which develops in patients in the setting of use of aminopenicillins (ampicillin, amoxicillin, inhibitor-protected aminopenicillins) [38][39][40][41]. Frequency of ampicillin rash development is 5-10%; it may reach 75-100% (32.9%, according to the data of 2013) in the event of the infection caused by Epstein-Barr virus (i.e.…”

“…Frequency of ampicillin rash development is 5-10%; it may reach 75-100% (32.9%, according to the data of 2013) in the event of the infection caused by Epstein-Barr virus (i.e. in the event of infectious mononucleosis) [30,[38][39][40]42]. Its distinctive feature is maculopapular rash (described for the first time in 1960s); it is not truly allergic in terms of the mechanism of development; it is not considered a risk factor of development of life-threatening reactions to penicillin; it manifests on the 4 th -5 th day of aminopenicillin therapy; it is not accompanied by pruritus; it passes itself within 3-6 days and does not usually pose a contraindication to the future use of aminopenicillins.…”

Wolfram Syndrome

“…[1][2][3][4][5][6][7][8][9] Nevertheless, many physicians remain skeptical\p=m-\even hostile\p=m-\tothe concept that diet can affect behavior. Moreover, the relationship of food sensitivity to systemic and nervous system symptoms in children has been described by numerous observers during the past 50 years.…”