Amphotericin-B-loaded polymer-functionalized reduced graphene oxides for Leishmania amazonensis chemo-photothermal therapy

Vitorino, Letícia S.; Santos, Thiago C. dos; Bessa, Isabela A. A.; Santos, Evelyn C. S.; Verçoza, Brunno Renato Farias; Oliveira, L. A. S. de; Rodrigues, Juliany Cola Fernandes; Ronconi, Célia M.

doi:10.1016/j.colsurfb.2021.112169

Cited by 9 publications

(12 citation statements)

References 51 publications

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“…Consequently, new therapeutic approaches have been proposed. CBM, such as graphene oxide and reduced graphene oxide, have been investigated for treating cutaneous Leishmaniasis based on PDT/PTT strategies with promising results (Ozpinar & Polat, 2020; Vitorino et al, 2022). Thus, this paves the way to apply other CBM as CDs in this field; until now, the CDs have not been sufficiently explored against protozoan parasites.…”

Section: Current and Future Prospects Of Cds To Combat Pathogensmentioning

confidence: 99%

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Lagos

García

Cuadrado

et al. 2023

WIREs Nanomed Nanobiotechnol

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Carbon dots (CDs) correspond to carbon‐based materials (CBM) with sizes usually below 10 nm. These nanomaterials exhibit attractive properties such us low toxicity, good stability, and high conductivity, which have promoted their thorough study over the past two decades. The current review describes four types of CDs: carbon quantum dots (CQDs), graphene quantum dots (GQDs), carbon nanodots (CNDs), and carbonized polymers dots (CPDs), together with the state of the art of the main routes for their preparation, either by “top‐down” or “bottom‐up” approaches. Moreover, among the various usages of CDs within biomedicine, we have focused on their application as a novel class of broad‐spectrum antibacterial agents, concretely, owing their photoactivation capability that triggers an enhanced antibacterial property. Our work presents the recent advances in this field addressing CDs, their composites and hybrids, applied as photosensitizers (PS), and photothermal agents (PA) within antibacterial strategies such as photodynamic therapy (PDT), photothermal therapy (PTT), and synchronic PDT/PTT. Furthermore, we discuss the prospects for the possible future development of large‐scale preparation of CDs, and the potential for these nanomaterials to be employed in applications to combat other pathogens harmful to human health. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

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Section: Current and Future Prospects Of Cds To Combat Pathogensmentioning

confidence: 99%

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Lagos

García

Cuadrado

et al. 2023

WIREs Nanomed Nanobiotechnol

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“…The functionalization of s-MS and r-MS was carried out following procedures that were well established by our group for different materials. ,,,,− The activated s-MS (0.60 g) and r-MS (0.40 g) materials were added to a bottom round flask containing PhMe (60 mL) and TESBN (2.0 mL), respectively, under stirring. The dispersions were maintained under reflux and N 2 atmosphere for 2 h. Then, an aliquot of each dispersion (1.5 mL) was removed from the system with subsequent addition of TESBN (0.6 mL).…”

Section: Methodsmentioning

confidence: 99%

Responsive Supramolecular Devices Assembled from Pillar[5]arene Nanogate and Mesoporous Silica for Cargo Release

Silva

Costa

Fernandes

et al. 2022

ACS Appl. Nano Mater.

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In this work, cationic switchable pillar[5]arene nanogates that bear an imidazolium scaffold (MIP5+) were constructed, and these nanogates were used to electrostatically interact with negatively charged spherical mesoporous silica nanoparticles (96.0 ± 1.0 nm) and rod-shaped silica particles (391.0 ± 0.2 nm in length and 219 in width), which are both functionalized with carboxypropyl groups. The nanochannels of silica-based materials were used as containers to store the anticancer drug doxorubicin (DXR) trapped by the nanogate. Under physiological conditions (pH = 7.4), DXR molecules were firmly trapped in the nanochannels of the spherical and rod-shaped containers without any premature release, demonstrating that the nanogate was efficient in sealing the nanopores. Under acidic conditions (pH = 4.5), the carboxypropyl groups were protonated, and the electrostatic interactions between the containers and the nanogates were disrupted, releasing the drug. In vitro studies were performed to explore the differences between N-methylimidazolium-pillar[5]arene nanogate mounted on DXR-loaded spherical and rod-shaped containers and the resulting cytotoxicity effect against human breast adenocarcinoma cells and cellular uptake. A higher cytotoxicity effect and better cellular uptake were detected for the nanogate on DXR-loaded rod-shaped silica containers. Additionally, this device presents a lower uptake rate by nontumor cells than that of free DXR. Therefore, our findings indicate that the rod shape of mesoporous silica in nanogated devices is important due to the cytotoxicity effect and cellular uptake and should be further explored in drug delivery systems.

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“…To prepare rGO-P123 and rGO-PEI we used graphene oxide (GO) obtained from a procedure previously described by our group based on modified Hummer's method [1,2] . GO was further reduced with hydrazine in the presence of poly(ethylene glycol)- block -poly(propylene glycol)- block -poly(ethylene glycol) (PEO 20 –PPO 70 –PEO 20 , Pluronic® P123) or branched polyethyleneimine (PEI).…”

Section: Data Descriptionmentioning

confidence: 99%

“…Cytotoxicity studies and antiproliferative assays against Leishmania amazonensis promastigotes were evaluated. The complete work data entitled Amphotericin-B-Loaded Polymer-Functionalized Reduced Graphene Oxides for Leishmania amazonensis Chemo-Photothermal Therapy have been published to Colloids and Surfaces B: Bionterfaces ( https://doi.org/10.1016/j.colsurfb.2021.112169 ) [1] .…”

mentioning

confidence: 99%

Fabrication data of two light-responsive systems to release an antileishmanial drug activated by infrared photothermal heating

et al. 2022

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The data provided in this study are related to the fabrication of two light-responsive systems based on reduced graphene oxide (rGO) functionalized with the polymers Pluronic P123 (P123), rGO-P123, and polyethyleneimine (PEI), rGO-PEI, and loaded with amphotericin B (AmB), an antileishmanial drug. Here are described the experimental design to obtain the systems and characterization methods, such as Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), Raman Spectroscopy, Powder X-Ray Diffraction, Transmission Electron Microscopy, Scanning Electron Microscopy and Thermogravimetric Analyses. Also, AmB spectroscopy studies are described. The materials rGO-P123 and rGO-PEI were loaded with AmB and the optimization of AmB and polymer fragments structures revealed several possible hydrogen bonds formed between the materials and the drug. The drug release was analyzed with and without Near-Infrared (NIR) light. In the studies conducted under NIR light irradiation for 10 min, an infrared lamp was disposed at 64 cm from the samples and an optical fiber thermometer was employed to measure the temperature variation. Cytotoxicity studies and antiproliferative assays against Leishmania amazonensis promastigotes were evaluated. The complete work data entitled Amphotericin-B-Loaded Polymer-Functionalized Reduced Graphene Oxides for Leishmania amazonensis Chemo-Photothermal Therapy have been published to Colloids and Surfaces B: Bionterfaces ( https://doi.org/10.1016/j.colsurfb.2021.112169 ) [1] .

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Amphotericin-B-loaded polymer-functionalized reduced graphene oxides for Leishmania amazonensis chemo-photothermal therapy

Cited by 9 publications

References 51 publications

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Responsive Supramolecular Devices Assembled from Pillar[5]arene Nanogate and Mesoporous Silica for Cargo Release

Fabrication data of two light-responsive systems to release an antileishmanial drug activated by infrared photothermal heating

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