Fabrication data of two light-responsive systems to release an antileishmanial drug activated by infrared photothermal heating

Abstract

The data provided in this study are related to the fabrication of two light-responsive systems based on reduced graphene oxide (rGO) functionalized with the polymers Pluronic P123 (P123), rGO-P123, and polyethyleneimine (PEI), rGO-PEI, and loaded with amphotericin B (AmB), an antileishmanial drug. Here are described the experimental design to obtain the systems and characterization methods, such as Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), Raman Spectroscopy, Powder X-Ray Diffraction, Transmission Electron Microscopy, Scanning Electron Microscopy and Thermogravimetric Analyses. Also, AmB spectroscopy studies are described. The materials rGO-P123 and rGO-PEI were loaded with AmB and the optimization of AmB and polymer fragments structures revealed several possible hydrogen bonds formed between the materials and the drug. The drug release was analyzed with and without Near-Infrared (NIR) light. In the studies conducted under NIR light irradiation for 10 min, an infrared lamp was disposed at 64 cm from the samples and an optical fiber thermometer was employed to measure the temperature variation. Cytotoxicity studies and antiproliferative assays against Leishmania amazonensis promastigotes were evaluated. The complete work data entitled Amphotericin-B-Loaded Polymer-Functionalized Reduced Graphene Oxides for Leishmania amazonensis Chemo-Photothermal Therapy have been published to Colloids and Surfaces B: Bionterfaces ( https://doi.org/10.1016/j.colsurfb.2021.112169 ) [1] .

Visible-Light-Responsive Photoreversible Color Switching of Oxygen-Deficient WO3–x Hierarchical Nanostructures for Long-Legible Rewritable Paper

“…2b). 43,44 The main FTIR peaks of WO 3−x hierarchical nanostructures match well with those of P123 and DEG, confirming the surface ligand modification arising from P123 and DEG. For WO 3 nanorods, there are no obvious FTIR peaks derived from P123 and DEG on the nanorods' surface.…”

“…The bandgap ( E g ) value of hierarchical nanostructures is calculated to be 2.76 eV using Kubelka–Munk (K–M) plots, which is smaller than that of WO 3 nanorods (2.93 eV) (inset in Figure a). The Fourier transform infrared (FTIR) spectra of P123 and DEG show the characteristic absorption peaks at 902, 1068, 1122, 1232, and 1350 cm –1 , which are corresponding to OC 2 H 4 , C–O, C–C–O, C–O–C, alkyl group stretching vibrations and alkyl group bending vibrations, respectively (Figure b). , The main FTIR peaks of WO 3– x hierarchical nanostructures match well with those of P123 and DEG, confirming the surface ligand modification arising from P123 and DEG. For WO 3 nanorods, there are no obvious FTIR peaks derived from P123 and DEG on the nanorods’ surface.…”

Antimicrobial and Cytotoxic Effect of Positively Charged Nanosilver-Coated Silk Sutures

“…In Figure b, the infrared spectroscopy analysis reveals the characteristic functional groups of the PEI polymer and P-AgNPs, including the stretching vibrations of the N–H amino group at 3265 cm –1 , CH 2 stretching vibrations at 2960 and 2832 cm –1 , NH 3+ species at 1655 cm –1 , NH 2 bending vibration at 1569 cm –1 , and CH 2 bending vibration at 1458 cm –1 . , The presence of these peaks was observed in both spectra; however, in the case of P-AgNPs, the intensity of PEI diminished, which corroborates that PEI was involved in the reduction and indicates successful coating on the surface of AgNPs, thereby helping in stabilization by electrostatic interactions, which prevents the aggregation of particles …”

Innovating Leishmaniasis Treatment: A Critical Chemist’s Review of Inorganic Nanomaterials

“…The higher drug release from rGO-PEI, compared to rGO-P123, was attributed to PEI's reducing properties, making rGO-PEI more reduced and thereby more responsive to NIR radiation. 185,214 The evaluation of chemical characteristics is crucial as they dictate the biological properties of the materials, a key focus of Ronconi's work. Using different polymers yielded materials with varying surface charges: rGO-P123 exhibited a negative surface charge, and rGO-PEI had a positive one.…”

“…This approach aims to facilitate the targeted delivery and on-demand release of the drug to infected cells. Contributing to this discussion, Ronconi and co-workers synthesized two drug delivery systems based on reduced graphene oxide (rGO) and biocompatible polymers. , The reduction of graphene oxide restores conjugated π bonds, enabling the material to absorb NIR radiation and convert it into localized heat, suggesting the potential for photothermal applications. However, to overcome rGO’s lack of biocompatibility, the team functionalized it with two different polymers: Pluronic P123 (P123) and polyethylenimine (PEI), resulting in rGO-P123 and rGO-PEI, respectively.…”